DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and FGD3

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_001077005.1 Gene:FGD3 / 89846 HGNCID:16027 Length:725 Species:Homo sapiens


Alignment Length:826 Identity:150/826 - (18%)
Similarity:270/826 - (32%) Gaps:260/826 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1320 STTPSTSGSVAA--------GLSAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKER 1376
            |:||  .|.:||        |.|:..:|.||                     ||           
Human     7 SSTP--PGPIAALGMPDTGPGSSSLGKLQAL---------------------PV----------- 37

  Fly  1377 LSNKRNRNSRRKTSDPSLSSRPNDEQLDLG----LSNATYVGSSNSSLSSAGGSESPSTSM--EH 1435
                   ..|....||...:...|...|:|    ||.:..:.:.:|      |.:|||:|:  |:
Human    38 -------GPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDS------GIDSPSSSVAGEN 89

  Fly  1436 FAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPL 1500
            |.   ...|::..|.......|..:.:.....:...|:.        |.|....           
Human    90 FP---CEEGLEAGPSPTVLGAHAEMALDSQVPKVTPQEE--------ADSDVGE----------- 132

  Fly  1501 PVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFF 1565
                   |.:.|:...:||..:.:|..      ...:|...|..|:..||..:|:.|.|||::|.
Human   133 -------EPDSENTPQKADKDAGLAQH------SGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184

  Fly  1566 LPLYESGLLSQDHLLLLFPPALL--------SLREIHGAF-EQSLKQRRIEHNHVVNTIGDLLAD 1621
            ..|.::|:          ||.::        |:...||.| ...||.|..|.......:||:|  
Human   185 TRLTDAGI----------PPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDIL-- 237

  Fly  1622 MFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQ 1686
                |......:...::......|:..:.....:..:.:.::...:..:.|..|.|:..:...:|
Human   238 ----QKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQ 298

  Fly  1687 RLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLD 1751
            |:.:|.||.::..|    .||::..:.:..:|::|.........|.|::..|..|||..:..:| 
Human   299 RVPRYELLLKDYLK----RLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQL- 358

  Fly  1752 RSSYDKEEFKKLDLTQ--HHLIHDG---NLTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLH 1811
                ..||    |:..  :.||.:|   .|:.|.......|..||.:||:....:     |:.:.
Human   359 ----GGEE----DIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPK-----LRLMG 410

  Fly  1812 TPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHFSDVAA 1876
            ...|:..|  ..|..:....:::...|  ::|.:...|.|  |||:..:..|.|.|.:.......
Human   411 QKFSVREK--MDISGLQVQDIVKPNTA--HTFIITGRKRS--LELQTRTEEEKKEWIQIIQATIE 469

  Fly  1877 RQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTP-LAPMLPIAT 1940
            :..:|                                 ::|.:......:....| |:|.:||.:
Human   470 KHKQN---------------------------------SETFKAFGGAFSQDEDPSLSPDMPITS 501

  Fly  1941 VTPA-PATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNR-TMSIRSTGEPIQ 2003
            .:|. |.......|...|::                    |:..||:...:: ..|.:|.||.. 
Human   502 TSPVEPVVTTEGSSGAAGLE--------------------PRKLSSKTRRDKEKQSCKSCGETF- 545

  Fly  2004 KYSANGTEANDVTLRH------------------SQSTRES-----------VRPGSTGEERNST 2039
                     |.:|.|.                  ::::|:|           |.|.||  |:..|
Human   546 ---------NSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPEST--EKTPT 599

  Fly  2040 YGMVGGNSKRDSASIVC-----SNNSNNTRTLLMQSPLVDPTAIQV 2080
                    .....|::|     |.:......:....|:.||..:.:
Human   600 --------ADPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHL 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 40/200 (20%)
PH_RhoGEF 1770..1875 CDD:275411 24/107 (22%)
DUF2413 2242..>2378 CDD:287302
FGD3NP_001077005.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..151 39/219 (18%)
RhoGEF 160..339 CDD:238091 40/198 (20%)
PH1_FGD3 371..478 CDD:275422 25/150 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..532 12/64 (19%)
FYVE_FGD3 531..584 CDD:277279 9/62 (15%)
PH2_FGD1-4 598..702 CDD:270056 7/48 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 703..725
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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