DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and ROM2

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_013475.1 Gene:ROM2 / 851086 SGDID:S000004363 Length:1356 Species:Saccharomyces cerevisiae


Alignment Length:1027 Identity:194/1027 - (18%)
Similarity:357/1027 - (34%) Gaps:315/1027 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   979 EIHS-TFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTV-FLRSRKRAKDLISEQLREFQ 1041
            :|:| .|.|.|.|.|:...|.....::.:  ||..:::|.::.: .|.|...|.|:|..     :
Yeast    14 DIYSQIFGVERRPDSFATFDSDSHGDISS--QLLPNRIENIQNLNVLLSEDIANDIIIA-----K 71

  Fly  1042 QKRTAGLGTIYGPTDDKLAEAKTDKLREQIIDKYLMPNLHALIEDENG--SPPEDVRKVALCSAL 1104
            |:|.:|:                    |..||...:||.....:..|.  |...::::|....:|
Yeast    72 QRRRSGV--------------------EAAIDDSDIPNNEMKGKSSNYILSQQTNIKEVPDTQSL 116

  Fly  1105 STVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQT 1169
            |:.    .||  |.||                    .|..:.....||:|           |.::
Yeast   117 SSA----DNT--PVSS--------------------PKKARDATSSHPIV-----------HAKS 144

  Fly  1170 IIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDV-IGN 1233
            :        .|......:..||.....|...|...|:.:....|...:.|:.|.:|....: :..
Yeast   145 M--------SHIYSTSNSASRQAKHYNDHPLPPMSPRNEVYQKNKSTTAFVPKRKPSLPQLALAG 201

  Fly  1234 EKRSRQDEELDVELTPDRGQASIVR------QPSDRR-----------PDANISIRSNGNTSCN- 1280
            .|:...........||.:.:.|.::      :||.:.           ...||:..:|.||:.| 
Yeast   202 LKKQSSFSTGSASTTPTQARKSPLQGFGFFSRPSSKDLHEQHQHHQHIQHNNINNHNNNNTNNNG 266

  Fly  1281 ----------------------TSGLNTTDLQ---SSF--------------------------- 1293
                                  :..||::.|:   |||                           
Yeast   267 AHYQVGSSNSNYPQHSHSISSRSMSLNSSTLKNIASSFQSKTSNSRKATQKYDITSNPFSDPHHH 331

  Fly  1294 ----HGSCANDSINPGGGAG-----------CNMDLSTSVASTT------PSTSGSVAAG--LSA 1335
                |.|.::.|:|...|:|           ..:.|.|.|:||:      .|.||:..:.  .|:
Yeast   332 HHHHHSSNSHSSLNNVHGSGNSSSVMGSSSNIGLGLKTRVSSTSLALKRYTSVSGTSLSSPRRSS 396

  Fly  1336 FAELNALDTVDKEARRERYSQHP--------KHKSAPVSVNRSESYKERLSNKRNRNSRR----- 1387
            ...|:|...| ..|..::...:|        |.||   |:...|..|:.|..:.....::     
Yeast   397 MTPLSASRPV-MSASSKKPQVYPALLSRVATKFKS---SIQLGEHKKDGLVYRDAFTGQQAVDVI 457

  Fly  1388 ----KTSDPSLS---------------------SRPNDEQLDLGLSNATYVGSS----------- 1416
                :|||.:|:                     .|.:..::.....|:.:.|:.           
Yeast   458 CAIIRTSDRNLALLFGRSLDAQKLFHDVVYEHRLRDSPHEVYEFTDNSRFTGTGSTNAHDPLMLL 522

  Fly  1417 -NSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMG--------LNQNQHP---------HLLIQ 1463
             |||..::|....|::.|...::..:....|....|        |:|.::|         ..|:.
Yeast   523 PNSSSFNSGNHSYPNSGMVPSSSTSSLNSDQATLTGSRLHMSSSLSQQKNPAAIHNVNGVFTLLA 587

  Fly  1464 QHAQQYCQQDSF------------QAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVN 1516
            :.....|.:|:.            ||.|..........|.|.               :.|:||..
Yeast   588 ECYSPTCTRDALCYSISCPRRLEQQARLNLKPNGGLKRNISM---------------ALDDDDEE 637

  Fly  1517 EADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLL 1581
            :..|:|.|:.|....|...|.||||.|.|:|.||:|.|::|::....|...|.|:.::|.|....
Yeast   638 KPSWTSSVSKEDWENLPKKEIKRQEAIYEVYITEKNFVKSLEITRDTFMKTLAETNIISADIRKN 702

  Fly  1582 LFPPALLSLREIHGAFEQSLK--QRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQI 1644
            ........:.:|:....:.||  ..|...:.||..|||::...      :...|....:.|.:..
Yeast   703 FIKHVFAHINDIYSVNRRFLKALTDRQRSSPVVRGIGDIVLRF------IPFFEPFVSYVASRPY 761

  Fly  1645 ALEALKEKRN--------KDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKV 1701
            |...::.:|:        .|:|:...|:..          :...|...:.|..:|.||.:.:.|.
Yeast   762 AKYLIETQRSVNPYFARFDDDMMSSSLRHG----------IDSFLSQGVSRPGRYMLLVKEIMKS 816

  Fly  1702 TVRLLPE-NTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDL 1765
            |.   || :.::.|.:.:|:::.:..:..::||...|:|.|.::.:::|:    ..|.|:..|.|
Yeast   817 TD---PEKDKSDYEDLSKAMDALRDFMKRIDQASGAAQDRHDVKLLKQKI----LFKNEYVNLGL 874

  Fly  1766 T--QHHLIHDGNLTIKKNP--------SVQLHGLLFENMIVLL-TKQDDKYY 1806
            .  :..:.|:|.|:.|:..        .:|.:  |.:||::.| .|..:|::
Yeast   875 NDERRKIKHEGILSRKELSKSDGTVVGDIQFY--LLDNMLLFLKAKAVNKWH 924

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710 19/77 (25%)
C1_1 1151..1202 CDD:278556 8/50 (16%)
RhoGEF 1539..1731 CDD:238091 43/202 (21%)
PH_RhoGEF 1770..1875 CDD:275411 11/46 (24%)
DUF2413 2242..>2378 CDD:287302
ROM2NP_013475.1 ROM1 4..1356 CDD:227709 194/1027 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9245
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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