Protein Alignment RhoGEF2 and fgd4b

DIOPT Version :9

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: XP_001332264.7
• Gene: fgd4b / 793364
• ZFINID: ZDB-GENE-110421-6
• Length: 775
• Species: Danio rerio
• Alignment Length: 615
• Identity: 128/615 - (20%)
• Similarity: 218/615 - (35%)
• Gaps: 137/615 - (22%)

  Fly  1355 SQHPKHKSAPVS-----VNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVG 1414
            |::.||||....     :|.....|..:..::.|..|      ::..|.:..|   |.:.|....
Zfish     7 SKNVKHKSIDAEKKGNVLNSCSDLKHHVHWQKTRFRR------AVGGRTSGSQ---GSAGAQVED 62

  Fly  1415 SSNSSLSSAGGSESPSTSMEHFAAPGAA----GGVQVPP-----------MGLNQNQHPHLLIQQ 1464
            |::|.|..|......|......|.|..|    ...|.||           ...|..........|
Zfish    63 SASSFLKDASSVLRKSAVYSVSAMPPPAVLPKPKFQCPPKISAANVIDGEQTDNDKTRERTTSDQ 127

  Fly  1465 HAQQYCQQDSFQAGLAGAAGSSAASNSSFWNA------------------GHPLPV------ARW 1505
            .|...|...||          ||:..||.|:.                  |:...|      :||
Zfish   128 SASSECAASSF----------SASDQSSGWDVWSGWWSEEVRGQQEESGRGNGASVEKEEEQSRW 182

  Fly  1506 TLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIIN---------EIYQTERNHVRTLKLLD 1561
            ..:..:||..|:.|..|:          :.::.:||.:|         |:.||||.:|..|.|||
Zfish   183 KQDGLNEDMENDEDKPSV----------ENDEDQQEQVNKLKLFKISSELLQTERAYVSRLHLLD 237

  Fly  1562 RLFFLPLYESGLLSQDHLLLLFPPALL--------SLREIHGAFEQSLKQRRIEHNHVVNTIGDL 1618
            ::|.:.|.|..|...      ||..::        |:...|..|.....:.|:........:||:
Zfish   238 QVFCVRLTEEALKGS------FPVDVVKGIFSNVGSIYTFHSQFLLPDLETRMSQWDSKPRVGDV 296

  Fly  1619 LADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPT 1683
            ||.:      .......|::......|:|.||....:......:::..:|.:.|..|.|:..:..
Zfish   297 LAQL------APFLRMYAEYVKNFDSAMELLKLWMERSTQFSAIIQDIQSQEVCGSLTLQHHMLE 355

  Fly  1684 VLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQR 1748
            .:||:.:|.:|.::..|    .|||:..:....|:::..........|.|::..|:..||..|..
Zfish   356 PVQRVPRYEMLLKDYLK----KLPEDDEDRSQAQKSLNIISMAATHSNMAIRKMENLKKLMEIYE 416

  Fly  1749 KLDRSSYDKEEFKKLDLT--QHHLIHDG---NLTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLK 1808
            .|     ..||    |:.  .:.||.:|   .|..:...|::.:..||.||::....:
Zfish   417 ML-----GGEE----DIVNPSNELIKEGQILKLAARNTSSMERYLFLFNNMLLYCVPK------- 465

  Fly  1809 NLHTPLSITNK--PVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHF 1871
                 .|:..:  .|...:.::...::.....|....|.:..| .:.|||:|.|..:.:.|.|.|
Zfish   466 -----FSLVGQRFTVRTRVRVEGMKVLETSNEDYPHTFQVSGK-ERTLELQASSQQDKEDWIKAF 524

  Fly  1872 SD-VAARQSKNRS-KNASSNHDTSISDPAL 1899
            .: :...|.||.: |:|.......:|...|
Zfish   525 QETIEIFQQKNETFKSACKEATDEVSKEEL 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	45/208 (22%)
		PH_RhoGEF	1770..1875	CDD:275411	22/110 (20%)
		DUF2413	2242..>2378	CDD:287302
fgd4b	XP_001332264.7	RhoGEF	221..399	CDD:214619	42/193 (22%)
		PH1_FDG4	431..524	CDD:275434	21/105 (20%)
		FYVE_FGD1_2_4	559..623	CDD:277280
		PH2_FGD1-4	645..748	CDD:270056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810