DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and net1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_001072884.2 Gene:net1 / 780346 XenbaseID:XB-GENE-487220 Length:585 Species:Xenopus tropicalis


Alignment Length:681 Identity:140/681 - (20%)
Similarity:264/681 - (38%) Gaps:176/681 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1375 ERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYV---GSSNSSLSSAGGSE--------- 1427
            |.:.:|:.:..:||:|..||:...:..:   |.|:..|.   |||.:.|:.  ||:         
 Frog    18 ENVKDKKRKGVKRKSSVSSLAGGQSTPE---GGSSRRYSLRRGSSFTFLTP--GSQWDFTLKRKR 77

  Fly  1428 ----------------SPS----------TSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHA 1466
                            .||          ||:.:..:|...|.|                  :..
 Frog    78 REKDDDALSLCSFDFKEPSTKRVRPLSRVTSLANLISPVRNGAV------------------RRF 124

  Fly  1467 QQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAA 1531
            .|..|..:.:|......|:..|.:    ....|.|..|          .|...||.|:...:..:
 Frog   125 GQTIQSFTMRAENKSPGGTQKACS----KVAAPTPPKR----------RNSVLWSEMLDINMKES 175

  Fly  1532 LTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGA 1596
            |:..|.||||.|.|:.:.|::.:..|||..:.:..|:.:..::|::.|..:|           |.
 Frog   176 LSTKEIKRQEAIFEMTKGEQDLIDDLKLARKAYHDPMLKLSIMSEEELTQIF-----------GD 229

  Fly  1597 FEQSLKQRRIEHNHVVNTIGDLL-ADMFDGQSGVVLCEFA------AQFCARQQIALEALKEKRN 1654
            .:..:..    |..::..:|:.. ||...||.|.:|..:.      .::|: .|:|.:||.:|:.
 Frog   230 LDSYIPL----HEELLAKLGEATKADGTVGQIGPILINWLPRLNAYKEYCS-NQLAAKALLDKKK 289

  Fly  1655 KDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRA 1719
            .|..:|..|::.......|:|:|...|.....||.|||||.:.:.:.|    |::..:.:.:..|
 Frog   290 LDRRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHT----PKDHPDTKGLHEA 350

  Fly  1720 VESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY--DKEEFKKLDLTQHHLIHDGNLTIKKNP 1782
            :...:.:|.::|  :|..|     ...|..:|:..|  ||::..:::.::..|.| |.|..|...
 Frog   351 LCLIQGVLTDIN--LKKGE-----SECQYYIDKLEYLDDKQKDLRIESSKALLCH-GELKNKNGH 407

  Fly  1783 SVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTL----IRQEAADKNSF 1843
            .:.|  .||::::||     .:..::|.|....:..:|: |:..:..:.|    :|...:.:.:|
 Frog   408 KLFL--FLFQDVLVL-----TRPVIRNEHQHFQVYRQPI-PVQDLVLEDLQDGDVRMGGSFRGAF 464

  Fly  1844 FLIKMKTSQMLELRAPSSSECKTWFK-HFSDVAARQSKNRSKNASSNHD-------TSISDPALA 1900
                           .:|.:.|..|: .|.|..|.||.....|...:..       |::| |...
 Frog   465 ---------------SNSDKAKNIFRVRFKDAGAGQSHTLQANDVFHKQQWLNCIKTAVS-PYQQ 513

  Fly  1901 AIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSN---VSSLTGVQLRN 1962
            |.| :..||..:|:.:..:         ..|             ||||:.:   .|:::|:...:
 Frog   514 ASP-TEQKELPDLNEECEE---------NNP-------------PATNSKDHRRSSTISGIMEMD 555

  Fly  1963 PQRDATASESDADYVNTPKPRSSQNEVNRTM 1993
            .:.:|.:|..|.  ..:||.|....:...|:
 Frog   556 LEENAFSSLLDT--TESPKTRDKTQQRKETL 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 46/198 (23%)
PH_RhoGEF 1770..1875 CDD:275411 22/109 (20%)
DUF2413 2242..>2378 CDD:287302
net1NP_001072884.2 RhoGEF 186..362 CDD:366202 43/195 (22%)
PH_Net1 376..510 CDD:270044 31/158 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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