DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and ITSN1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens


Alignment Length:2001 Identity:340/2001 - (16%)
Similarity:611/2001 - (30%) Gaps:712/2001 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 PGATSAGPSAG----APQSPVIVVDSVP--ELPAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLA 116
            |.|.|:.|:.|    |...|:..|..||  .:|.                       :..||:|.
Human   106 PVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPV-----------------------VGMSPTLV 147

  Fly   117 SSLSSLA-SSLSGHRDRDKDRDKDRENQNAVPPQTPPLPPSYKQNQMNGDSTAAAGGGVSAPATP 180
            ||:.:.| ..|:                |..||...|||                     |.|.|
Human   148 SSVPTAAVPPLA----------------NGAPPVIQPLP---------------------AFAHP 175

  Fly   181 TTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTP 245
            ......::|.:..   |.|.|||                    |.|.:       .:|...|:.|
Human   176 AATLPKSSSFSRS---GPGSQLN--------------------TKLQK-------AQSFDVASVP 210

  Fly   246 STPSLALPKNFQYLTLTVRKDSNGYGMKVSGD------NPVFVESVKPGGAAEIAG--------- 295
            .....|:|::.:   |..|:..|.:...:||.      ..:.::|..|  .|::|.         
Human   211 PVAEWAVPQSSR---LKYRQLFNSHDKTMSGHLTGPQARTILMQSSLP--QAQLASIWNLSDIDQ 270

  Fly   296 ---LVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVKRSQKLTRPSSVSVVT--------P 349
               |.|.:.||.::..:|.:...|     :......|......:::...|.:||::        |
Human   271 DGKLTAEEFILAMHLIDVAMSGQP-----LPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLP 330

  Fly   350 STPILSG------------------------------------------RDRTASI-TGPQPVDS 371
            ..|:|..                                          ::|.|.: ...|....
Human   331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKE 395

  Fly   372 IKRREMETYKIQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKLREQ-------------LH 423
            .:|:|.|..:...|:|.||::: .|||.:.::.....:..||..|:|..|             |:
Human   396 RERQEQERKRQLELEKQLEKQR-ELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLN 459

  Fly   424 QVGAEDAPTVKLQA----------AAGNKNTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNN 478
            |...|....|.|:|          |..:|...|  ..::|.:....|...|:....:....|...
Human   460 QRNKEQEDIVVLKAKKKTLEFELEALNDKKHQL--EGKLQDIRCRLTTQRQEIESTNKSRELRIA 522

  Fly   479 NYPPQQQPASTSPAFLS-LLPRS--LSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQ-- 538
            .....||....|...|. |:|..  |:......::|...:|...:....|....|.:|.:..|  
Human   523 EITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLD 587

  Fly   539 -AESMSQSMHQHTSTPTSQ--QFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRN 600
             .|..::|..|......:|  :....|.:|...|:....::...:....|.:||.:......||.
Human   588 EVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRR 652

  Fly   601 PPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQQQLPSSTDNS-----PSNAKSKRS 660
                                    ..:.|:.....:.:..:.|.|......     ..:.|.|..
Human   653 ------------------------AQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693

  Fly   661 KIKTKALSDPKMSTQMFLQMESASAAGAAGGSIEVDGGPPPLPPRLPGMMTEDMSRGSCQNLAQP 725
            :.|.|..:..|:........|.|..|..|..| ..:.||..:.                   ||.
Human   694 EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWS-TAEKGPLTIS-------------------AQE 738

  Fly   726 NSVGTAFN--YPLVSTTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQQ---HQMSGGQATGALG 785
            |.....:.  ||..|.:    :|.:.|     |..:||....::..:.|   ....||:..|..|
Human   739 NVKVVYYRALYPFESRS----HDEITI-----QPGDIVMVKGEWVDESQTGEPGWLGGELKGKTG 794

  Fly   786 QTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSG---SWEIVEKDG----ESSPPGTPP---PPY 840
            ..|   .|...::   |:|..|.....:|.:||.   ...:.|...    .||.|.|.|   ..:
Human   795 WFP---ANYAEKI---PENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADF 853

  Fly   841 LSSSHMTVLEDPNENNRGAAAAGPGVFIES-------HQFTP-MAGASSPIPISLHSSHMHAAQS 897
            .|:...:..|.|..:|..|.||.|.:.:.|       ..||| .|..|||.|:......:...|:
Human   854 SSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQA 918

  Fly   898 NDTQKEII----SMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLF 958
                 :.:    :.:|.:.:.::         |::..:||.:::.:.                  
Human   919 -----QALYPWRAKKDNHLNFNK---------NDVITVLEQQDMWWF------------------ 951

  Fly   959 YLITELYKEGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFL 1023
                     |..:..:.|            .|.|:.:                            
Human   952 ---------GEVQGQKGW------------FPKSYVK---------------------------- 967

  Fly  1024 RSRKRAKDLISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLREQIIDKYLMPNLHALIEDEN 1088
                    |||..:|    |.|:                                     ::..:
Human   968 --------LISGPIR----KSTS-------------------------------------MDSGS 983

  Fly  1089 GSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPL 1153
            ...|..:::||..:|                                         |..|.|...
Human   984 SESPASLKRVASPAA-----------------------------------------KPVVSGEEF 1007

  Fly  1154 VLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISK 1218
            :....||             .|.||                                        
Human  1008 IAMYTYE-------------SSEQG---------------------------------------- 1019

  Fly  1219 FMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSG 1283
                                       :||..:|...:|             .:.:|:....|.|
Human  1020 ---------------------------DLTFQQGDVILV-------------TKKDGDWWTGTVG 1044

  Fly  1284 LNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKE 1348
            .......|::                  :.|..|..|.|...:||:.                  
Human  1045 DKAGVFPSNY------------------VRLKDSEGSGTAGKTGSLG------------------ 1073

  Fly  1349 ARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDP------SLSSRPNDEQLDLGL 1407
                     .|.:.|.|..:.:.:..|:|:....:....:..:|      .|.:|....|  :|.
Human  1074 ---------KKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQ--IGW 1127

  Fly  1408 SNATYVGSSNSSLSSAGGSESP-STSMEHFAAPGAAGGVQV-----------PPMGLNQNQHPHL 1460
            ..|.||...:...|....:|.| ||::        |...||           ..:..|:.|..::
Human  1128 FPANYVKLLSPGTSKITPTEPPKSTAL--------AAVCQVIGMYDYTAQNDDELAFNKGQIINV 1184

  Fly  1461 LIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVA 1525
            |.::....:..:.:.|.||                  .|....:.|.:.:...     .|.|.: 
Human  1185 LNKEDPDWWKGEVNGQVGL------------------FPSNYVKLTTDMDPSQ-----QWCSDL- 1225

  Fly  1526 AEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSL 1590
             .:|..||..|:|||..|:|:..||.|:|..|:|:..:|..||.||.||::..:.::|    ::.
Human  1226 -HLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIF----VNW 1285

  Fly  1591 REIHGAFEQSLKQRRIE-----HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALK 1650
            :|:.....:.||..|:.     ....|..|||:|:.........:      :||:||......::
Human  1286 KELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYI------RFCSRQLNGAALIQ 1344

  Fly  1651 EKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEA 1715
            :|.::....::.:|:......|:.:.|...:...:||:|:|||:.:|:.:.|    |||..:...
Human  1345 QKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENT----PENHPDHSH 1405

  Fly  1716 IQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKE-EFKKLD--LTQHHLIHDGNLT 1777
            ::.|:|.::.:..:||:.|:..|::.:|:.||..:......:: .|..:.  |.....:|.|.| 
Human  1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKL- 1469

  Fly  1778 IKKNPSVQLHGLLFENMIVL--LTKQ-----DDKYY-------LKNLHTPLSIT----------- 1817
            .|...:.:|:|.||.:.::|  :||.     .||.:       .|...||:.:.           
Human  1470 YKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPS 1534

  Fly  1818 -NKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTW 1867
             ::|:..|..||....:|.|:.::.:.::.|:|.:..|.:........|.:
Human  1535 GDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAY 1585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 16/91 (18%)
RGS_GEF_like 934..1055 CDD:188710 10/120 (8%)
C1_1 1151..1202 CDD:278556 5/50 (10%)
RhoGEF 1539..1731 CDD:238091 48/196 (24%)
PH_RhoGEF 1770..1875 CDD:275411 26/124 (21%)
DUF2413 2242..>2378 CDD:287302
ITSN1NP_003015.2 EH 14..108 CDD:197477 1/1 (100%)
EH 26..90 CDD:238009
EH 214..309 CDD:197477 18/104 (17%)
EH 225..291 CDD:238009 13/67 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348 3/25 (12%)
KLERQ 326..702 66/402 (16%)
GBP_C <331..414 CDD:303769 10/82 (12%)
COG1340 372..686 CDD:224259 59/340 (17%)
coiled coil 383..394 CDD:293879 2/10 (20%)
coiled coil 403..414 CDD:293879 2/10 (20%)
AAA_23 <509..636 CDD:290211 21/126 (17%)
GBP_C <616..686 CDD:303769 10/93 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 9/74 (12%)
SH3_Intersectin1_1 744..803 CDD:212920 15/70 (21%)
INTAP 803..917 CDD:293223 29/116 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 8/31 (26%)
SH3_Intersectin1_2 917..968 CDD:212922 9/139 (6%)
SH3_Intersectin1_3 1006..1057 CDD:212924 13/161 (8%)
SH3_Intersectin1_4 1074..1138 CDD:212926 13/65 (20%)
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138 13/65 (20%)
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127 4/24 (17%)
SH3_Intersectin1_5 1158..1211 CDD:212928 9/70 (13%)
RhoGEF 1242..1422 CDD:279015 47/193 (24%)
PH_ITSN 1448..1579 CDD:270084 27/131 (21%)
PH 1465..1571 CDD:278594 24/106 (23%)
C2_Intersectin 1582..1716 CDD:176021 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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