Sequence 1: | NP_477317.1 | Gene: | RhoGEF2 / 36915 | FlyBaseID: | FBgn0023172 | Length: | 2559 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_003015.2 | Gene: | ITSN1 / 6453 | HGNCID: | 6183 | Length: | 1721 | Species: | Homo sapiens |
Alignment Length: | 2001 | Identity: | 340/2001 - (16%) |
---|---|---|---|
Similarity: | 611/2001 - (30%) | Gaps: | 712/2001 - (35%) |
- Green bases have known domain annotations that are detailed below.
Fly 58 PGATSAGPSAG----APQSPVIVVDSVP--ELPAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLA 116
Fly 117 SSLSSLA-SSLSGHRDRDKDRDKDRENQNAVPPQTPPLPPSYKQNQMNGDSTAAAGGGVSAPATP 180
Fly 181 TTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTP 245
Fly 246 STPSLALPKNFQYLTLTVRKDSNGYGMKVSGD------NPVFVESVKPGGAAEIAG--------- 295
Fly 296 ---LVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVKRSQKLTRPSSVSVVT--------P 349
Fly 350 STPILSG------------------------------------------RDRTASI-TGPQPVDS 371
Fly 372 IKRREMETYKIQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKLREQ-------------LH 423
Fly 424 QVGAEDAPTVKLQA----------AAGNKNTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNN 478
Fly 479 NYPPQQQPASTSPAFLS-LLPRS--LSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQ-- 538
Fly 539 -AESMSQSMHQHTSTPTSQ--QFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRN 600
Fly 601 PPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQQQLPSSTDNS-----PSNAKSKRS 660
Fly 661 KIKTKALSDPKMSTQMFLQMESASAAGAAGGSIEVDGGPPPLPPRLPGMMTEDMSRGSCQNLAQP 725
Fly 726 NSVGTAFN--YPLVSTTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQQ---HQMSGGQATGALG 785
Fly 786 QTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSG---SWEIVEKDG----ESSPPGTPP---PPY 840
Fly 841 LSSSHMTVLEDPNENNRGAAAAGPGVFIES-------HQFTP-MAGASSPIPISLHSSHMHAAQS 897
Fly 898 NDTQKEII----SMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLF 958
Fly 959 YLITELYKEGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFL 1023
Fly 1024 RSRKRAKDLISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLREQIIDKYLMPNLHALIEDEN 1088
Fly 1089 GSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPL 1153
Fly 1154 VLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISK 1218
Fly 1219 FMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSG 1283
Fly 1284 LNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKE 1348
Fly 1349 ARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDP------SLSSRPNDEQLDLGL 1407
Fly 1408 SNATYVGSSNSSLSSAGGSESP-STSMEHFAAPGAAGGVQV-----------PPMGLNQNQHPHL 1460
Fly 1461 LIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVA 1525
Fly 1526 AEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSL 1590
Fly 1591 REIHGAFEQSLKQRRIE-----HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALK 1650
Fly 1651 EKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEA 1715
Fly 1716 IQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKE-EFKKLD--LTQHHLIHDGNLT 1777
Fly 1778 IKKNPSVQLHGLLFENMIVL--LTKQ-----DDKYY-------LKNLHTPLSIT----------- 1817
Fly 1818 -NKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTW 1867 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
RhoGEF2 | NP_477317.1 | PDZ | 260..334 | CDD:214570 | 16/91 (18%) |
RGS_GEF_like | 934..1055 | CDD:188710 | 10/120 (8%) | ||
C1_1 | 1151..1202 | CDD:278556 | 5/50 (10%) | ||
RhoGEF | 1539..1731 | CDD:238091 | 48/196 (24%) | ||
PH_RhoGEF | 1770..1875 | CDD:275411 | 26/124 (21%) | ||
DUF2413 | 2242..>2378 | CDD:287302 | |||
ITSN1 | NP_003015.2 | EH | 14..108 | CDD:197477 | 1/1 (100%) |
EH | 26..90 | CDD:238009 | |||
EH | 214..309 | CDD:197477 | 18/104 (17%) | ||
EH | 225..291 | CDD:238009 | 13/67 (19%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 322..348 | 3/25 (12%) | |||
KLERQ | 326..702 | 66/402 (16%) | |||
GBP_C | <331..414 | CDD:303769 | 10/82 (12%) | ||
COG1340 | 372..686 | CDD:224259 | 59/340 (17%) | ||
coiled coil | 383..394 | CDD:293879 | 2/10 (20%) | ||
coiled coil | 403..414 | CDD:293879 | 2/10 (20%) | ||
AAA_23 | <509..636 | CDD:290211 | 21/126 (17%) | ||
GBP_C | <616..686 | CDD:303769 | 10/93 (11%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 650..701 | 9/74 (12%) | |||
SH3_Intersectin1_1 | 744..803 | CDD:212920 | 15/70 (21%) | ||
INTAP | 803..917 | CDD:293223 | 29/116 (25%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 836..868 | 8/31 (26%) | |||
SH3_Intersectin1_2 | 917..968 | CDD:212922 | 9/139 (6%) | ||
SH3_Intersectin1_3 | 1006..1057 | CDD:212924 | 13/161 (8%) | ||
SH3_Intersectin1_4 | 1074..1138 | CDD:212926 | 13/65 (20%) | ||
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 | 1074..1138 | 13/65 (20%) | |||
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 | 1104..1127 | 4/24 (17%) | |||
SH3_Intersectin1_5 | 1158..1211 | CDD:212928 | 9/70 (13%) | ||
RhoGEF | 1242..1422 | CDD:279015 | 47/193 (24%) | ||
PH_ITSN | 1448..1579 | CDD:270084 | 27/131 (21%) | ||
PH | 1465..1571 | CDD:278594 | 24/106 (23%) | ||
C2_Intersectin | 1582..1716 | CDD:176021 | 1/4 (25%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG5422 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |