DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Arhgef26

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001074764.1	Gene:	Arhgef26 / 622434	MGIID:	1918053	Length:	869	Species:	Mus musculus

Alignment Length:	818	Identity:	157/818 - (19%)
Similarity:	293/818 - (35%)	Gaps:	180/818 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1175 SPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQ 1239
            ||.|...||..          |:|....|.||.......|...:.:.    |:..::...:|...
Mouse    41 SPSGLLITDFP----------VEELAALPTPQTPVRVPADPDDRTVS----RSPQLLSAHRRPVT 91

  Fly  1240 DEELDVELTPDRGQASIVRQPSDRRPDAN-ISIRSNGNTSCNTSG---------LNTTDLQSSFH 1294
            :..   .::||...||    |..|||.:. :|..::|.:..:||.         |:.........
Mouse    92 NGR---TVSPDYRAAS----PRLRRPKSPLVSYAASGGSPKSTSNGTVASPAALLSRASRTPDTP 149

  Fly  1295 GSCANDSINPGGGAG-CNMDLSTSVASTTPSTSGSVA-----AGLSAFAELNALDTVDKEARRER 1353
            .|||.|....|..|. .:..::..:|..|.| ||.|:     ||             |.|....|
Mouse   150 ASCATDEDCTGVTASKVSSPIANGLAHKTDS-SGPVSQTGQPAG-------------DLELAPSR 200

  Fly  1354 YSQHPKHKSAP---------------------VSVNR----------------SESYKERLSNKR 1381
            .|....|||:.                     :|.|.                :...|...||.:
Mouse   201 LSPALPHKSSEQKLPLQRLPSQGNELPNPSVVLSTNSPAALKMGKQQIIPKSLASEIKLSKSNSQ 265

  Fly  1382 NRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSES--PSTSMEHFAAPGAAGG 1444
            |..|.|:.    |..|...|.|...|.:....|..::.:.|.|....  .|||.......|....
Mouse   266 NVESHRRL----LKVRSMVEGLGAPLGHEGEEGEVDNDMDSPGSLRRGLRSTSYRRAVVSGFDFD 326

  Fly  1445 VQVPPMGLNQNQHPHL-LIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLE 1508
            ........|:...|.| .:.:..:::......:..:....|:.....::.....:.....  .::
Mouse   327 SPTSSKKKNRMSQPVLKAVMEDKEKFSSLGRIKKKILKGQGTFDGEENAVLYQNYKEKAL--DID 389

  Fly  1509 SEDEDDVNE---------------ADWSSMVAAE---VLAALTDAEKKRQEIINEIYQTERNHVR 1555
            |::|.:..|               :.||.:.|.:   :...::..|:||||.|.|:..:|.:::.
Mouse   390 SDEEPEAKEQKAEERIVIHHKPLRSTWSQLSAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYLL 454

  Fly  1556 TLKLLDRLF--FLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLK-----QRRIEHNHVVN 1613
            :|::|.|:|  ...|.::...::.|.|         ...|...:|.|.|     :.|.::|..:.
Mouse   455 SLEILIRMFKNSKELTDTMTKTERHHL---------FSNITDVWEASKKFFTELEARHQNNIFIE 510

  Fly  1614 TIGDLL----ADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRR 1674
            .|.|::    |..||..         .::|..:......|::....:...:::|.:.|||:.||.
Mouse   511 DISDIVEKHTASTFDPY---------VKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRN 566

  Fly  1675 LELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAED 1739
            |.:...|...:||:|:.|||.:.:.:.|    |:::.:.|..:||::...:::...|:..:..|.
Mouse   567 LPMISFLILPMQRVTRLPLLMDTICQKT----PKDSPKYEVCKRALKEVSKLVRLCNEGARKMER 627

  Fly  1740 AHKLQNIQRKLDRSSYDKEEFK----KLDLTQHHLIHDGNLTI---------KKNPSVQLHGLLF 1791
            ...:..|..:|        |||    .|..:...|:..|.||.         |:....|::..||
Mouse   628 TEMMYTINSQL--------EFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSKRMSKQQVYFFLF 684

  Fly  1792 ENMIVLLTKQDDKYYLKN---LHTPL---SITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKT 1850
            .:::::..|:.::.|..|   |...|   |..|:.::.....:..|::....:.....|.:.:.:
Mouse   685 NDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNPSTMLYSRQSSATHLFTLTVLS 749

  Fly  1851 SQMLE-----LRAPSSSECKTWFKHFSDVAARQSKNRS 1883
            :...|     |.|.:.||...|.......:.:|..:|:
Mouse   750 NHASEKVDMLLGAETQSERARWITALGHSSGKQPPDRT 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	7/26 (27%)
		RhoGEF	1539..1731	CDD:238091	45/202 (22%)
		PH_RhoGEF	1770..1875	CDD:275411	23/124 (19%)
		DUF2413	2242..>2378	CDD:287302
Arhgef26	NP_001074764.1	RhoGEF	441..620	CDD:279015	42/200 (21%)
		PH_ephexin	641..779	CDD:269929	25/137 (18%)
		SH3_ARHGEF16_26	791..845	CDD:212871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810