DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and Arhgef1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_038944848.1 Gene:Arhgef1 / 60323 RGDID:620951 Length:979 Species:Rattus norvegicus


Alignment Length:1255 Identity:308/1255 - (24%)
Similarity:493/1255 - (39%) Gaps:352/1255 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   858 GAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDEN--SDLDEPFID 920
            |.||.||          |.:|.     :|:                ||..|||:  ::|:....|
  Rat     6 GGAAPGP----------PRSGL-----VSI----------------IIGAEDEDFENELEANPED 39

  Fly   921 ENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHSTFL 985
            :|..|.:|.::  ......|...|.:|....:|.|||..|..::......|:.:|...:.:.:||
  Rat    40 QNSQFQSLEQV--KRRPAHLMALLQHVALQFEPGPLLCCLHADMLSSLGPKEAKKAFLDFYHSFL 102

  Fly   986 ----VPRAPLSWYRQDESLAREVDNV---LQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQK 1043
                |.|.|:     ..|:|.|:|..   |..|..:...::.| ::|::.|   ::.||.:|:.|
  Rat   103 EKTAVLRVPV-----PPSVAFELDRTRPDLISEDVQRRFIQEV-VQSQQAA---VTRQLEDFRSK 158

  Fly  1044 RTAGLGTIYGPTDDKLA-------------EAKTDKLREQIIDKYLMPNLHALIEDENGSPPEDV 1095
            |..|:    .|.:.:|:             ||:...:.|::: .:|....|.:..||.       
  Rat   159 RLMGM----TPWEQELSLLEPWIGKDRGNYEARERHVAERLL-SHLEEMQHTISTDEE------- 211

  Fly  1096 RKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKS---------FKSRIMGKNRKMNVRGH 1151
            :..|:.:|:|  :|               :.|...|.||         |:.::||..|.      
  Rat   212 KSAAVVTAIS--LY---------------MRHLGVRTKSGDKKSGRNFFRKKVMGNRRS------ 253

  Fly  1152 PLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKI 1216
                                                         ||.     |:.|:     .:
  Rat   254 ---------------------------------------------DEP-----PKTKK-----GL 263

  Fly  1217 SKFMGKIR-----PRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGN 1276
            |..:...|     |...|.          ..|.||:....|       |:||:....||.|   :
  Rat   264 SSILDPARWNRGEPSAPDC----------RHLKVEVDEKPG-------PADRKGSLGISSR---D 308

  Fly  1277 TSCNTSGLNTTDLQSSFHGSCAN--DSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAEL 1339
            .:..|.|.:...:  |.|....:  ||..||      :|.......|.|.       |.::...|
  Rat   309 RTVGTPGQDNPGV--SLHPLSVDSLDSREPG------VDTPQEPGDTPPQ-------GPTSLEPL 358

  Fly  1340 NALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLD 1404
            ...::.:.....||     :.|.....:.||||.  |:|:      ||:.|..||.::       
  Rat   359 APPESTEDNGETER-----RWKRLSGRLGRSESL--RVSD------RRRPSRGSLGAK------- 403

  Fly  1405 LGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQY 1469
                            ...||.......|:    ||:|..|    :|..:...|           
  Rat   404 ----------------GRGGGRSRSDVDMD----PGSATAV----LGPTRRATP----------- 433

  Fly  1470 CQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTD 1534
                  :.|..|..|.|.                   ||.|.|:   ...|..:|.::.|..|..
  Rat   434 ------EPGDDGEPGRSG-------------------LEQEPEE---PPGWRELVPSDTLLGLPK 470

  Fly  1535 AEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQ 1599
            .:.||||:|:|:..||..|||.|::|..||:.|:.|.|....:.|..:| |:|..|.|:|..|..
  Rat   471 NQVKRQEVISELLVTEAAHVRMLRVLHDLFYQPMAEGGFFPLEELQNIF-PSLDELIEVHSLFLD 534

  Fly  1600 SLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLK 1664
            .|.:||.|..:::..|||:|...|||..|....:.:::||:||..|||.||.|:.|:......::
  Rat   535 RLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCAFVQ 599

  Fly  1665 KSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVE 1729
            ::||...||||:|||::||.:|||||||||.:::.:.|     |...|...::.|.|..:.||..
  Rat   600 EAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-----EEPAERAKVELAAECCREILHH 659

  Fly  1730 VNQAVKTAEDAHKLQNIQRKLD----RSSYDK--EEFKKLDLTQHHLIHDGNLT--IKKNPSVQL 1786
            |||||:..||..:|::.||:||    |.|.|.  .|||.||:|:..|:|:|.||  :.|:.:|::
  Rat   660 VNQAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKKLVHEGPLTWRLTKDKAVEV 724

  Fly  1787 HGLLFENMIVLLTKQDDKYYLKNLH----TPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIK 1847
            |.||.:::::||.:||::..||: |    ||.......:.|::.: ...:.|:.|.|..:|::|.
  Rat   725 HVLLLDDLLLLLQRQDERLLLKS-HSRTLTPTPDGKTMLRPVLRL-TSAMTREVATDHKAFYVIF 787

  Fly  1848 M--KTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPH-----S 1905
            .  :.:|:.||.|.:|||.|:|....::.|.                |:..||.|:.|.     |
  Rat   788 TWDQEAQIYELVAQTSSERKSWCALITETAG----------------SLKVPAPASRPKPRPSPS 836

  Fly  1906 NTKESL----ELSTDTVQPLAATATLTTTPLAPMLPIATVTPAP-----ATNNSNVSSLTGVQLR 1961
            :|:|.|    |..|...:...|.|. |...|..:||..  .|.|     ||....|.||..:.|.
  Rat   837 STREPLLSSSENGTGGTEAAPADAR-TERILNDLLPFC--RPGPEGQLAATALQKVLSLKQILLS 898

  Fly  1962 NPQRDATASESDADYV---NTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQS- 2022
            ..:........|.|.|   ..|.|..:|......:|:....:.:::     .|.....||...| 
  Rat   899 TEEDSGAGPPRDGDGVPGGGAPGPTHTQEVEENLLSLEVVIKQLEE-----LEEEFCRLRPFLSQ 958

  Fly  2023 TRESVRPGSTGEERNSTYGM 2042
            ..|.:.|.....||::..|:
  Rat   959 LGEILSPNLAAPERSAQTGL 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710 30/127 (24%)
C1_1 1151..1202 CDD:278556 2/50 (4%)
RhoGEF 1539..1731 CDD:238091 75/191 (39%)
PH_RhoGEF 1770..1875 CDD:275411 34/112 (30%)
DUF2413 2242..>2378 CDD:287302
Arhgef1XP_038944848.1 RGS_p115RhoGEF 50..242 CDD:188709 47/231 (20%)
RhoGEF 478..662 CDD:214619 73/189 (39%)
PH_p115RhoGEF 696..820 CDD:275429 40/141 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340346
Domainoid 1 1.000 135 1.000 Domainoid score I4839
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 327 1.000 Inparanoid score I2383
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D163264at33208
OrthoFinder 1 1.000 - - FOG0001574
OrthoInspector 1 1.000 - - otm46036
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45872
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.000

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