DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and PLEKHG5

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001252522.1	Gene:	PLEKHG5 / 57449	HGNCID:	29105	Length:	1075	Species:	Homo sapiens

Alignment Length:	1205	Identity:	235/1205 - (19%)
Similarity:	399/1205 - (33%)	Gaps:	362/1205 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1180 HCTDCKLNIHRQCSKVVDESCPGPL---------------PQAKRLAHNDKISKFMGKIRPRTSD 1229
            |..||: .:||:....:.|:|....               ||...||.|....    ...||||.
Human    43 HHADCQ-QLHRRGPLNLCEACDSKFHSTMHYDGHVRFDLPPQGSVLARNVSTR----SCPPRTSP 102

  Fly  1230 VIGNEKRSRQDEELDVELTPDRGQA--SIVRQPSDRRP-------------DANISIRSNGNTSC 1279
            .:..|:   ::||..|:...||...  .:.::.:.||.             |.|:.|.
Human   103 AVDLEE---EEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIE------- 157

  Fly  1280 NTSGLNTTDLQSSFHGSCANDSINPG--------GGAGCNMDLSTSVASTT-------------- 1322
                   |::..:.......:.:.|.        |.....:|.|.:..|.|
Human   158 -------TEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVK 215

  Fly  1323 ----PSTSGSVAAGLSAFAELN------------ALDTVDKEARRERYSQHPKHKSAPVSVNRSE 1371
                |...|.|..|:.....|:            ||:.||.::||                   |
Human   216 APAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRR-------------------E 261

  Fly  1372 SYKERLSNKRNRNSRRKTSDPSLSSR----PNDEQLDLGLSNATYVGSS--NSSLSSAGG--SES 1428
            |.......:|.:|......:.|:..:    |:...|..|.|.:|..|.|  |.:.|...|  |..
Human   262 SLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSG 326

  Fly  1429 PSTSMEHFAAPGAAGGVQVPPM-GLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSS 1492
            ||||         |.|.:|..| .|....|.:.|.               ||..........:.|
Human   327 PSTS---------AFGREVDKMEQLEGKLHTYSLF---------------GLPRLPRGLRFDHDS 367

  Fly  1493 FWNAGHPLPVARWTLE-SEDEDDVN-----EADWSSMVAAEVLAALTDAEKKRQEIINEIYQTER 1551
                        |..| .||||:.|     |..|..::...  ..||..:..:||.:.|:..||.
Human   368 ------------WEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEA 418

  Fly  1552 NHVRTLKLLDRLF---FLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVN 1613
            :::|.|:::..||   .|.|.|||||.:.....|| ..:..:.::|.....|:....:|......
Human   419 SYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLF-SNIPEIAQLHRRLWASVMAPVLEKARRTR 482

  Fly  1614 TI---GDLLA--DMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACR 1673
            .:   ||.|.  .||..     |.:...::|..::..:|.::.....:::.:..:..:|.|..|:
Human   483 ALLQPGDFLKGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQ 542

  Fly  1674 RLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAE 1738
            ||:|.|:|....|||||||||.:::.:.|     |.....||:...:.|.:|.:..||..::..:
Human   543 RLKLSDMLAKPHQRLTKYPLLLKSVLRKT-----EEPRAKEAVVAMIGSVERFIHHVNACMRQRQ 602

  Fly  1739 DAHKLQNIQRKLD-----RSSYDK-----EEFKKLDLT----------QHHLIHDGNLTIK--KN 1781
            :..:|..:..::|     .||.|:     :||..||||          ...|:.:|:|.:|  |:
Human   603 ERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKD 667

  Fly  1782 PSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLI 1846
            ..:.::..||.::: |:||...|.....:..|         |::   .|.::.:|..|..||.||
Human   668 SKMDVYCFLFTDLL-LVTKAVKKAERTRVIRP---------PLL---VDKIVCRELRDPGSFLLI 719

  Fly  1847 KMKTSQ----MLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNT 1907
            .:....    ....:|...:.|:.|..     ....::|:.:...:........|.
Human   720 YLNEFHSAVGAYTFQASGQALCRGWVD-----TIYNAQNQLQQLRAQEPPGSQQPL--------- 770

  Fly  1908 KESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASES 1972
             :|||...|..:.                                      :....:.:....:|
Human   771 -QSLEEEEDEQEE--------------------------------------EEEEEEEEEEGEDS 796

  Fly  1973 DADYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSAN--GTEANDVTLRHSQSTRESVRPGSTGEE 2035
            .....::|           |:..:|:|.|..::.|:  .||...:.:         |.||.|...
Human   797 GTSAASSP-----------TIMRKSSGSPDSQHCASDGSTETLAMVV---------VEPGDTLSS 841

  Fly  2036 RNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPL-------------VDPTAIQVSISPAHT 2087
            .....|.....|...|.|...| ::..|..||...|:             :.||::|..::|...
Human   842 PEFDSGPFSSQSDETSLSTTAS-SATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 905

  Fly  2088 AE-----------PVLTPGEKLRRLDASIRNDLLEKQKIICDIFRLPVEHYDQIVDIAMMPEAPK 2141
            ||           |...|..:|||                    |.||:.      ::..|...|
Human   906 AELVPRAPESPRVPSPPPSPRLRR--------------------RTPVQL------LSCPPHLLK 944

  Fly  2142 DSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHCHEKEKLRKKVAPSSSFSSSPPP 2206
            ..::.:|     :|.|...........|.:.:|.:..||.......:...::..||.....:|.|
Human   945 SKSEASL-----LQLLAGAGTHGTPSAPSRSLSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSP 1004

  Fly  2207 ----------LPPPNRQHAQAQAQIPPSRLMPKLQ 2231
                      ...|...|.:....: ||...|::|
Human  1005 GSGPGLVGCLAGEPAGSHRKRCGDL-PSGASPRVQ 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	7/21 (33%)
		RhoGEF	1539..1731	CDD:238091	52/199 (26%)
		PH_RhoGEF	1770..1875	CDD:275411	23/110 (21%)
		DUF2413	2242..>2378	CDD:287302
PLEKHG5	NP_001252522.1	RhoGEF	409..596	CDD:214619	51/197 (26%)
PLEKHG5	NP_001252522.1	PH_PLEKHG5_G6	652..750	CDD:270064	23/115 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810