DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and arhgef19

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_005162265.1	Gene:	arhgef19 / 569202	ZFINID:	ZDB-GENE-090313-243	Length:	958	Species:	Danio rerio

Alignment Length:	958	Identity:	200/958 - (20%)
Similarity:	352/958 - (36%)	Gaps:	248/958 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1134 SFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTI----IWGVSPQGYH-CT--DCKLNIHRQ 1191
            |.:::.:..:|:    |.|| |||:..:..|.. :|:    :...|..|:. ||  :|..::
Zfish    34 SVETQALSDSRE----GRPL-LRQHQHIAVCQQ-ETLAFIDLQEQSVNGFQSCTSENCSSSL--- 89

  Fly  1192 CSKVVDESCPGPLP------QAKRLAHNDKISKFMGKIR-------------PRT------SDVI 1231
            |||.:  .|.|..|      ::...|.:|.:::.:..:.             |.|      |.|.
Zfish    90 CSKPL--RCNGRSPSDFAKTESTDRALDDYLTEDINNVEVVQEQSWTYITGLPETVHENPDSGVK 152

  Fly  1232 G----------------NEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCN 1280
            |                .::.|.:.::|....:|..|       |...||....|:.|....|..
Zfish   153 GLNPRNLFLPLSPIYAPGDRNSLESQQLSSPSSPLEG-------PDPFRPQRRTSLGSIKEKSIR 210

  Fly  1281 TS----GLNTTDLQSSFHG-SCANDSINPG-------GGAGCNMDLSTSVASTTPSTSGSVAAGL 1333
            ..    ..:|.:...|..| .|  |.:.|.       ||.|  |..||...|.|.|....:...|
Zfish   211 RKMRVYSPDTLEASPSSPGVEC--DYLLPASFESFVEGGLG--MVGSTIPTSQTSSPLPGLDEDL 271

  Fly  1334 SAFAELNA----LDTVDKEAR---------RERYSQH--------PKHKSAPVSVNRSESYKERL 1377
            |.||..|:    |:.:.:.||         |:|....        |.:....:.::||.|    :
Zfish   272 SLFAIPNSPKPFLNPLQEGARCQEGVNDEGRQRLGLEDCGTLQGPPLNSGTSMPLSRSRS----V 332

  Fly  1378 SNKRNRNSRRK-TSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGA 1441
            .|:|.|.|..: .|...||.|.|...|.||.|.:..|.|....||....|:....|...|:...:
Zfish   333 DNERRRFSASELISRLQLSQRKNSFTLKLGKSLSARVASRERHLSGNLSSDYKPNSRHRFSGGSS 397

  Fly  1442 AGGV-----QVPPM-GLNQNQHPH----------------------------------LLIQQHA 1466
            ..|.     ..||: ..:.||..|                                  :|.|:::
Zfish   398 DSGPHSPVGSAPPLPSADSNQPLHRRSSKQRMRKVSVDEDGGSPPSNSKRLSRFLPSLILYQEYS 462

  Fly  1467 -----QQYCQQDSFQAGLAGAAGSSAA----SNSSFWNAGHPLPVARWTLESEDEDDVNEADWSS 1522
                 ::..:|...:.|.....|.|.:    |.||.:.:......:.|    :|..||.
Zfish   463 DVAINREIQRQQGAEPGTDEERGESVSPGNLSPSSSFRSSRGSAFSLW----QDIPDVR------ 517

  Fly  1523 MVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPAL 1587
              ::..|...::.|:|.||...|:..:|.:::|:|.:....|.:.......|.......|| ..|
Zfish   518 --SSGQLDNFSNEERKLQEAKFELVTSEASYIRSLSIAVDHFMMSSELCECLGTQERQWLF-SKL 579

  Fly  1588 LSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFC-ARQQIALEALKE 1651
            ..::|:...|.|.| :||:|        ||:|  .||      :|:.....| |.:::.|..:..
Zfish   580 PDVKEVSERFLQDL-ERRLE--------GDIL--RFD------VCDIVLDHCPALRRVYLPYVTN 627

  Fly  1652 KRNKDEMLQKLLKKS----------ESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLL 1706
            :..:::..|:||:::          |....|:||.|...|....||:|:..:|.||:.|   |..
Zfish   628 QAYQEQTYQRLLQENARFPGILARLEEDPICQRLPLTSFLILPFQRITRLKMLVENILK---RTT 689

  Fly  1707 PENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKL------------DRSSYDKEE 1759
            |.:..| :...:|:...|:|:.|.|.:|::.:...:|.::.:|:            .|......|
Zfish   690 PGSRDE-DTATKALNELKKIIKECNSSVQSMKRMEELIHLNKKIHFEGKIFPLISQSRWLVKHGE 753

  Fly  1760 FKKLDLTQHHLIHDGNLTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPI 1824
            ..::| ||:..|......:...| |.||  ||.:.::|..:::...::..:|          :.|
Zfish   754 LLEVD-TQNLSISGSKFKLTTRP-VYLH--LFNDCLLLSRRKESWKFMVFVH----------AKI 804

  Fly  1825 MSIDADTLIRQEAADKNSFFLIKMKTSQMLE----LRAPSSSECKTW----FKHFSDVAARQSKN 1881
            ..:....|.::........|.:::...|.|:    |::|:.|..:.|    |......|..|:
Zfish   805 EDLKVKDLSQKLQGISGFIFYLQLCEGQQLKHQILLKSPTESSKQRWITAMFPSDPTTAIEQT-- 867

  Fly  1882 RSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTT 1929
                 :.|.|.|    .:..|.....:|..||:.:....|.| .|:|:
Zfish   868 -----NENDDLS----QVQCIRSYQAQEHDELTLEKADILQA-VTITS 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	16/57 (28%)
		RhoGEF	1539..1731	CDD:238091	50/202 (25%)
		PH_RhoGEF	1770..1875	CDD:275411	19/112 (17%)
		DUF2413	2242..>2378	CDD:287302
arhgef19	XP_005162265.1	RhoGEF	537..713	CDD:279015	48/197 (24%)
		PH_ephexin	735..862	CDD:269929	24/140 (17%)
		PH	748..855	CDD:278594	22/120 (18%)
		SH3_ARHGEF5_19	875..929	CDD:212873	8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810