DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and ngef

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_697546.3 Gene:ngef / 569090 ZFINID:ZDB-GENE-130530-794 Length:718 Species:Danio rerio


Alignment Length:655 Identity:134/655 - (20%)
Similarity:237/655 - (36%) Gaps:168/655 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1350 RRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVG 1414
            ::|..|..||....|.|.||   .....:|:...:.|.:.|.||.|.      :.| |||....|
Zfish    69 QQESPSSSPKPTVDPASYNR---LSPAAANRVPLSPRLQKSPPSRSG------ISL-LSNGVQGG 123

  Fly  1415 -SSNSSLSSAGG----------SESPSTSM------EHFAAPG-------AAGGVQVPPM----- 1450
             .|.|.|:|.|.          ||..:::.      .|..|..       ...|.....|     
Zfish   124 VRSRSPLASPGDWPRRLEMEELSERTTSACTMQDNDNHSTADPDNITFRLVRNGDSPQKMAVENS 188

  Fly  1451 --GLNQNQHPHLLIQQH----AQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLES 1509
              .||..::..:|.|::    .||...|...:.||. .|||..              :|...|:.
Zfish   189 CHNLNIMKNVDVLYQEYRDTSKQQEIDQRRQRDGLP-TAGSGV--------------LAAPALQL 238

  Fly  1510 EDEDDVNEAD-WSSMVAAEVLAALTDAEKKR---QEIINEIYQTERNHVRTLKLLDRLFFLPLYE 1570
            :.....|..: |.::.|.:....|...|.|.   ||.:.|:..:|.::.::|:||:..|......
Zfish   239 QLRSSTNSLNLWQNLDAVKKSGLLQTLEPKEIILQEAMFELVTSEASYYKSLELLETHFLRNPLL 303

  Fly  1571 SGLLSQDHLLLLFPPALLSLREIHGAFEQSLK--QRRIEHNHVVNTIGDLLADMFDGQSGVVLCE 1633
            ...|||..:..||.    ::.:|..|.|:.|.  :.|||.:.:::.:.|::             .
Zfish   304 VNTLSQSDMHFLFS----NITDIMKASEKFLMDLEHRIEESILISDVCDIV-------------H 351

  Fly  1634 FAA--QFCARQQIALEALKEKRNKDEMLQK---------LLKKSESHKACRRLELKDLLPTVLQR 1687
            |.|  .|.......:..:.::.|...:||:         :|   |:....:.|.....|....||
Zfish   352 FHAVNHFQVFISYVINQVYQETNYRRILQENCAFRENMAIL---ENQPKVKGLSFTSFLILPFQR 413

  Fly  1688 LTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDR 1752
            :|:..||.:|:.|    .:.||:.:......|.:..::|:.:.|:..:......:|.:|::.|  
Zfish   414 ITRLKLLVQNILK----RVEENSEKERTAILAHQELEKIVKQCNEGARKMSRTEELISIEKTL-- 472

  Fly  1753 SSYDKEEFKKLDLTQHHLIHDGNLTIKKNPSVQLHG------------------LLFENMIVLLT 1799
                  |||...:.   :|......:||....|:.|                  .||.|:: |:|
Zfish   473 ------EFKSKSVP---VISHSRWLLKKGEVQQMSGPKSTRTMRSRKLYHPIYLFLFNNLL-LIT 527

  Fly  1800 KQD---DKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSF----FLIKMKTSQ----- 1852
            |::   ||:.:                :.|.....|..::..|:...    |::|:..:|     
Zfish   528 KRNSSGDKFQV----------------LDSCSRSMLRTEDLEDQGQMLACVFVLKLLENQEDREV 576

  Fly  1853 MLELRAPSSSECKTWFKHFSDVAARQSKNRSKNAS-SNHDTSISDPALAAIPHSNTKESLELSTD 1916
            ...|:..|.|:...|      :.|.....|::..| |.|:.  ..|.:..|...:::|..|||.:
Zfish   577 SYMLKTESVSDKLRW------ICALTPNRRTRFLSTSTHEP--DSPQVQCIQSYSSQEPDELSVE 633

  Fly  1917 TVQPL 1921
            ....|
Zfish   634 MADVL 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 42/207 (20%)
PH_RhoGEF 1770..1875 CDD:275411 23/134 (17%)
DUF2413 2242..>2378 CDD:287302
ngefXP_697546.3 RhoGEF 275..454 CDD:279015 40/202 (20%)
PH_ephexin 475..601 CDD:269929 25/151 (17%)
SH3 615..668 CDD:302595 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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