DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and Net1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_062645.2 Gene:Net1 / 56349 MGIID:1927138 Length:595 Species:Mus musculus


Alignment Length:609 Identity:126/609 - (20%)
Similarity:230/609 - (37%) Gaps:162/609 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1358 PKHKSAPVSVNRSE------------SYKERLSNKR-----------------NRNSRRKTSDP- 1392
            |:.:|..||:...|            :..||.|.:|                 .|..|.|..|. 
Mouse    13 PRRRSRRVSMLSEEPAAGLPADTPGPAANERCSLRRGSSFTFLTPGPHWDFTLKRKRREKDDDAV 77

  Fly  1393 SLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPS----------TSMEHFAAPGAAGGVQV 1447
            ||||      |||                     :.||          ||:.:..:|...|.|: 
Mouse    78 SLSS------LDL---------------------KEPSNKRVRPLARVTSLANLISPVRNGAVR- 114

  Fly  1448 PPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDE 1512
                         ...|..|.:.        |.|...|.|::..||..:..|.|..|        
Mouse   115 -------------RFGQTIQSFT--------LRGDHRSPASAQKSFSRSTVPTPTKR-------- 150

  Fly  1513 DDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQD 1577
              .:.|.||.|:...:..:||..|.||||.|.|:.:.|::.:..|||..:.:..|:.:..::|::
Mouse   151 --RSSALWSEMLDINMKESLTTREIKRQEAIYELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEE 213

  Fly  1578 HLLLLFP--PALLSLRE-IHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFC 1639
            .|..:|.  .|.:.|.| :.....::.|.     :..|..||.:|.:...|.:..      ..:|
Mouse   214 ELTHIFGDLDAYIPLHEDLLARIGEATKP-----DGTVEQIGHILVNWLPGLNAY------RGYC 267

  Fly  1640 ARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVR 1704
            : .|:|.:||.:::.:|..:|..|::.......|:|:|...|.....||.|||||.:.:.:.|  
Mouse   268 S-NQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHT-- 329

  Fly  1705 LLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY--DKEEFKKLDLTQ 1767
              |::..:.:.::.|:...:.:|.::|  :|..|     ...|..:::..|  :|::..:::.::
Mouse   330 --PKDHRDVQLLEEAILIIQGVLSDIN--LKKGE-----SECQYYINKLEYLDEKQKDPRIEASK 385

  Fly  1768 HHLIHDGNLTIKKNPSVQLHGLLFENMIVL---LTKQDDKYYLKNLHTPLSITNKPVSPIMSIDA 1829
            ..|.| |.|  |.....:|:..||::::||   :|:.:...|        .:..:|: |:..:..
Mouse   386 VLLCH-GEL--KNKSGHKLYIFLFQDILVLTRPVTRNERHLY--------QVYRQPI-PVQELVL 438

  Fly  1830 DTL----IRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFK-HFSDVAARQSKNRSKNASSN 1889
            :.|    :|...:.:.:|               .:|.:.|..|: .|.|.:...|.....|...:
Mouse   439 EDLQDGDVRMGGSFRGAF---------------GNSDKAKNIFRVRFQDPSPGHSHTLQANDVFH 488

  Fly  1890 HDTSISDPALAAIPHSNTKESLEL 1913
            .....:....|..|.......|||
Mouse   489 KQQWFNCIRAAIAPFQRAASPLEL 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 45/194 (23%)
PH_RhoGEF 1770..1875 CDD:275411 22/112 (20%)
DUF2413 2242..>2378 CDD:287302
Net1NP_062645.2 Necessary for nuclear localization 1..74 12/60 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42 5/28 (18%)
Nuclear localization signal 12..19 2/5 (40%)
Nuclear localization signal 66..72 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..151 8/33 (24%)
RhoGEF 178..354 CDD:214619 42/191 (22%)
PH_Net1 368..502 CDD:270044 27/160 (17%)
PH 387..501 CDD:278594 25/140 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..595
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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