DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and arhgef2

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_021328624.1 Gene:arhgef2 / 561276 ZFINID:ZDB-GENE-030717-1 Length:872 Species:Danio rerio


Alignment Length:965 Identity:217/965 - (22%)
Similarity:368/965 - (38%) Gaps:223/965 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1203 PLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDA 1267
            |||:|::....|..:|...|.|.:..:....|:.||.                            
Zfish     7 PLPKARQERMKDNNAKNKEKERMKAREKETKERESRY---------------------------- 43

  Fly  1268 NISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAG 1332
                 |||:...:.| ::.|.|.|:                 ||..::...|.:.|:.:.::   
Zfish    44 -----SNGHLFTSLS-VSATTLCSA-----------------CNKSITAKEALSCPTCNVTI--- 82

  Fly  1333 LSAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRN----RNSRRKTSDPS 1393
                                    |.:.:....:..:.:..::||:..||    .|...::.:|.
Zfish    83 ------------------------HNRCRDTLANCAKMKQKQQRLALGRNTATLHNVALRSKNPI 123

  Fly  1394 LSSRPNDEQLDLGLSNATYVGS--SNSSLSSAGGSESPSTSMEHFAAPGAAGGV-QVPPMGLNQN 1455
            |..||:...........:::||  ..||||.   ::|.||:       ..||.: ...|:||.: 
Zfish   124 LKERPSSAIYPSETLRQSFLGSRKGRSSLSL---NKSVSTN-------NIAGSLNDDSPIGLRR- 177

  Fly  1456 QHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADW 1520
                  |..|:     .||..      ..:.|.|..|..:.|.....:.......|..|.....|
Zfish   178 ------ILSHS-----TDSLN------FRNRAMSMESLNDEGETYYTSMMEELERDGKDFAADSW 225

  Fly  1521 SSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPP 1585
            |..|.:..|.:......|||::|.|:.|||.||||||::::.:|...:.|..::....:..:| |
Zfish   226 SLAVDSSYLQSQRKDVIKRQDVIYELIQTEFNHVRTLRIMEGVFRRGMLEEVMMEMGVVHAIF-P 289

  Fly  1586 ALLSLREIHGAFEQSLKQRR-------IEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQ 1643
            .|..|..||..|...|.|||       ...|..:..:||:|.:.|.||:...:.:...:||:|..
Zfish   290 CLDQLLLIHTNFLSQLLQRRSNSLASNSNRNFTIQKLGDILVEQFSGQNAEDMRKCYVEFCSRHL 354

  Fly  1644 IALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPE 1708
            .|::..||...:|:..|:.:::.......||..:::.:..|.||:||||:|.:.:...|    ..
Zfish   355 KAVKLYKELLARDKRFQQFIRRVSRGSLLRRHGVQECILLVTQRITKYPVLMQRILDNT----KG 415

  Fly  1709 NTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEE----FKKLDLTQHH 1769
            |..|::::.:::...:.:|..|:|.|:..|.|.:||.||.:||..:..|.:    |...:|.:..
Zfish   416 NEEESKSLAQSLTLIRELLCSVDQQVQELERAQRLQEIQSRLDPRAETKVKGGGVFHGAELLRRG 480

  Fly  1770 LIHDGNLTIKKNPSVQL---HGLLFENMIVLLTKQDDKYYLKNLHTP--LSITNKPVSPIMSIDA 1829
            |||:|.|..|.....:|   |.||..:::|.:.::|.||....|..|  |.:.|           
Zfish   481 LIHEGALLWKTAQGSRLKDVHVLLMTDVLVFMQEKDQKYVFPTLDKPSVLCLQN----------- 534

  Fly  1830 DTLIRQEAADKNSFFLIKMKT-SQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTS 1893
             .::|..|..:...|||...| .:|.||.|.|..:..||.|......:        |..|..|..
Zfish   535 -LIVRDIANQQRGMFLISHSTPPEMYELHAASKDDRNTWMKIIQQTVS--------NCPSREDFP 590

  Fly  1894 I---SDPA----LAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSN 1951
            :   .|.|    |.|......:|.|||..:.|           |..:.::        .||...|
Zfish   591 LIETEDKALLRRLRADIQQKDREVLELLQERV-----------TLFSDLV--------EATGGQN 636

  Fly  1952 VSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQN----EVNRTMSI--RSTGEPIQKYSANGT 2010
            |:.        |........:|..|  .|:.....|    ||:|...:  .|..|..|....|| 
Zfish   637 VTV--------PTNSRNIFRADTPY--APQAEKLLNEAIVEVDRLSDVLLSSCIERPQSCRLNG- 690

  Fly  2011 EANDVTLRHSQSTRESV-------RPGSTGEERNSTYGMVGGNSKRDSA--SIVCSNNSN-NTRT 2065
            ||.:|.|....:.:|.:       ..|.:.::||       ||...|..  ..||....| :|:.
Zfish   691 EATEVQLTSKTADKERISVNGTYDTNGPSNKDRN-------GNQLLDKLLNEEVCQRLVNLSTQL 748

  Fly  2066 LLMQSPLVDPTA-----IQVSISPAHTAEPVLTPGE--KLRRLDASIRNDLLEKQ 2113
            ..:|:.::...:     :|...||. |..|..:.|:  :|:|....::.:::..|
Zfish   749 HSIQAAVIRQDSFLEVYMQKESSPT-TGTPAGSVGDFAELQRKYNQLQGEMIRLQ 802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 55/198 (28%)
PH_RhoGEF 1770..1875 CDD:275411 32/110 (29%)
DUF2413 2242..>2378 CDD:287302
arhgef2XP_021328624.1 C1 47..92 CDD:237996 9/89 (10%)
RhoGEF 244..438 CDD:238091 55/198 (28%)
PH-like 478..595 CDD:327399 35/136 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580172
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.740

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