DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and fgd1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_688794.4 Gene:fgd1 / 560305 ZFINID:ZDB-GENE-081104-33 Length:995 Species:Danio rerio


Alignment Length:900 Identity:170/900 - (18%)
Similarity:299/900 - (33%) Gaps:245/900 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1109 YRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMN----VRGH-----------PLVLRQY 1158
            |.|.:..|.|...:.|     :...|...|::.|:..::    :..|           ||     
Zfish    33 YHISSGLPSPQPALRR-----TGSSSSSPRLLTKSLSLDPGPCLGAHETPQRLCSDPGPL----- 87

  Fly  1159 YEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKI 1223
             |..|||       |.|..|                  .:..|.|.|:.:......|     .::
Zfish    88 -EPQHCN-------GTSENG------------------PQDVPPPPPKTRPPLPGPK-----PQV 121

  Fly  1224 RPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTS--CNTSGLNT 1286
            .|:...:  .::.:|:....|..|.|......:   |:|.|.......|:.|::|  |..|.:..
Zfish   122 PPKPPHL--QQQNARRPRPPDKPLPPPPPSRPL---PADPRQSRATMPRAEGSSSPTCVLSLIEK 181

  Fly  1287 TDLQSSFHGSCANDSINPG--GGAGCN---MDLSTSVASTTPSTSGSVAAGLSAFAELNA----- 1341
            .:.:...        :.|.  ||..|.   .|...:..|.:|.||..:....|....|.|     
Zfish   182 FEREQII--------VVPDITGGVMCTPRVPDQQATPGSLSPQTSEFILPCTSLQEPLEAPLAED 238

  Fly  1342 -LDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSD-----PSLSSRPND 1400
             |:..:||...|......:...:.:..:.|:   :|||.:....:..|..|     .:.|..|:|
Zfish   239 ELEKEEKEEEEEEDVDETEEDDSELGASCSD---KRLSMESGYGASDKLLDNMEMTANQSEIPSD 300

  Fly  1401 E------QLDLGLSNATYVGSSNSSLSSAGGSE----------------------SPSTSMEHFA 1437
            .      |:|..|:|.   .|...|:||...||                      .|..|..:..
Zfish   301 RLSLPPAQMDGKLANR---DSGIDSISSPSHSEELCFVGDEDRVGHEREICPCSPGPGISCSYVE 362

  Fly  1438 APG--AAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPL 1500
            .|.  .|||                   :.|.:..:.||   .|...:|..:..|..   |..||
Zfish   363 GPDEEGAGG-------------------EEAGRDSEGDS---DLEEGSGDESEMNPM---ALQPL 402

  Fly  1501 PVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFF 1565
            |.|    |.:|..:::                  .:::...|.||:..||:.:|..|.|||::|.
Zfish   403 PKA----ERQDSTEMS------------------VQQRVFNIANELLHTEKAYVSRLHLLDQVFC 445

  Fly  1566 LPLYES-------------GLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGD 1617
            ..|.|.             |:.|.          :.|:...|..|.....::|:|...:...|||
Zfish   446 AQLMEEARARSSFPCEMVMGIFSN----------ICSIYCFHQQFLLPALEKRMEEWDLNPRIGD 500

  Fly  1618 LLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLP 1682
            :|      |......:...::......|:|.:.....:....:.::...:..:.|..|.|:..:.
Zfish   501 IL------QKLAPFLKMYGEYVKNFDRAMELVNTWMQRSSQFKTIIHNIQKEEMCGNLTLQHHML 559

  Fly  1683 TVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQ 1747
            ..:||:.:|.||.::.    :..|||:..:.:..|:::|.........|.|::..|...||..:.
Zfish   560 EPVQRIPRYELLLKDY----LHRLPEDADDFKDAQKSLELIATAAEHSNAAIRKMERMRKLLKVY 620

  Fly  1748 RKLDRSSYDKEEFKKLDLTQ--HHLIHDGN---LTIKKNPSVQLHGLLFENMIVLLTKQDDKYYL 1807
            ..|     ..||    |:..  :.||.:|:   |:.|...|...:.:||.:.::....:      
Zfish   621 ELL-----GGEE----DIVNPTNELIKEGHILKLSAKNGTSQDRYLILFNDRLLYCVPK------ 670

  Fly  1808 KNLHTPLSITNKPVSPIMSIDADTLIRQEAADKN--SFFLIKMKTSQMLELRAPSSSECKTWFKH 1870
                  |.:..:.......||.|.:..:|.:..|  ..||:..| .:.|||:|.:..|.:.|.:.
Zfish   671 ------LRLIGQKFGVRARIDVDGMELKETSSMNVPRTFLVSGK-QRSLELQARTEEEKRDWIQA 728

  Fly  1871 FSDVAARQSKN----RSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPL 1921
            ......|..:.    |..|.|...: .::.|        |:....||......|:
Zfish   729 IQATIQRHEQTLETFRMLNCSFREE-DLTPP--------NSPNCSELGKRAPTPI 774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556 10/61 (16%)
RhoGEF 1539..1731 CDD:238091 40/204 (20%)
PH_RhoGEF 1770..1875 CDD:275411 23/109 (21%)
DUF2413 2242..>2378 CDD:287302
fgd1XP_688794.4 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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