Protein Alignment RhoGEF2 and si:ch73-15b2.5

DIOPT Version :9

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: XP_686873.2
• Gene: si:ch73-15b2.5 / 558551
• ZFINID: ZDB-GENE-030131-5406
• Length: 532
• Species: Danio rerio
• Alignment Length: 609
• Identity: 115/609 - (18%)
• Similarity: 231/609 - (37%)
• Gaps: 160/609 - (26%)

  Fly  1336 FAELNALDTVDKEAR--RERYSQHPKHK---------------------------------SAPV 1365
            |..|...:.:|:.||  .:.|....|.|                                 |.|:
Zfish    10 FWNLTGTEVLDRTARPAMDEYDPPTKEKDSEACGGNYCTSEGLAETLRSVASSQLWSFVGYSLPI 74

  Fly  1366 -SVNRSESYKE-RLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGL-SNATYVGSSNSSLSSAGGSE 1427
             |:..:|||.. ..|:..:.:|..|    |:|      ::|:.: ...|||....|...::
Zfish    75 ASLFSAESYSHLEFSDMNSDDSEVK----SIS------EMDVSVQQEKTYVAKFESEYINS---- 125

  Fly  1428 SPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAA---- 1488
                              .||            |.|::..:..::|..:|.|||.:...|:
Zfish   126 ------------------SVP------------LYQEYWMRSFKKDLNRAQLAGLSELVASVCLP 160

  Fly  1489 --------SNSSFWNAGHP--LPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEII 1543
                    |.:|..:...|  .|.|.|....:              |..||.:|:..:.:.||.:
Zfish   161 GLKTPPSLSPTSVLSPPGPQSKPYALWQELPQ--------------AKSVLYSLSAQDIQLQEAM 211

  Fly  1544 NEIYQTERNHVRTLKLLDRLFFLPLYESGLLS--QDHLLLLFPPALLSLREIHGAFEQSLK--QR 1604
            .|:..:|.::.::|.:...:|........:|:  |.|:|      ..:|:::....|:.|:  :.
Zfish   212 FELIVSEASYQKSLIVALNVFQCSAELKHILTRVQHHVL------FSNLKDVCRVSERFLQDLES 270

  Fly  1605 RIEHNHVVNTIGDLLADMFDGQSGV--VLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSE 1667
            .:..:.|::.:||:   :.:.|...  |...:......::.:..:.|:|.|.    ...:|||.|
Zfish   271 HLRQDVVMSQVGDV---VLNHQKSFQQVYVPYITNMMYQEALVTQLLQENRK----FAPILKKLE 328

  Fly  1668 SHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQ 1732
            ....|:|..||..|....||:|:..||.||:.| ..|.:..|...   ::.|:|:.::|:.|.:.
Zfish   329 KDPQCQRQTLKSFLILPFQRITRITLLLENVLK-RARGVSLNVPN---VKEAIEAVRKIVEECDT 389

  Fly  1733 AVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLIHDGNL-----------TIKKNPSVQL 1786
            .|:..:....|.::.:.:|   :...:...|.....||:.:|.|           :|.....:.:
Zfish   390 RVQKMKRTELLVSLDKLVD---FGNVKAVPLITRGRHLVQEGTLKQLIIGGNHKASIVSRKDLYI 451

  Fly  1787 HGLLFENMIVLLTKQDDKYYLKNLHT--PLSITNKPV-SPIMSIDADTLIRQEAADKNSFFLIKM 1848
            |  ||.::::|..:...::.::: |.  |..:..:.: :.|:.:.:::|:.......|
Zfish   452 H--LFNDLLLLSVRSGQRFLVQD-HALFPDHVRAEEIKTTILGLPSESLLLHLTKKHN------- 506

  Fly  1849 KTSQMLELRAPSSSECKTWFKHFS 1872
            ::|..|.|.|.:..|.:||.|..|
Zfish   507 RSSSALILAARNELEKETWIKALS 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	44/197 (22%)
		PH_RhoGEF	1770..1875	CDD:275411	22/117 (19%)
		DUF2413	2242..>2378	CDD:287302
si:ch73-15b2.5	XP_686873.2	RhoGEF	210..388	CDD:279015	42/194 (22%)
		PH-like	412..532	CDD:302622	24/129 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810