DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and arhgef15b

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_009304999.1 Gene:arhgef15b / 555489 ZFINID:ZDB-GENE-060810-103 Length:937 Species:Danio rerio


Alignment Length:1303 Identity:234/1303 - (17%)
Similarity:393/1303 - (30%) Gaps:531/1303 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   700 PPLPPRLPGMMTED---------MSRGSCQNL----AQPNSVGTAFNYPLVSTTTAVQNDNLNIA 751
            ||:|.: |.:.|.|         .|.|:.:|:    :||.|     ..||..|..:|..:     
Zfish    19 PPVPSK-PSITTTDSSSVDTAASQSSGNVKNIVNKFSQPES-----KPPLGETVKSVNTE----- 72

  Fly   752 FPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNL-GKNKHRRVGS-SPDNM--HPRHPDR 812
             ..||||..|:..::         |...:..:.|..|.| .|.:...:.| ..|.:  ..||.:.
Zfish    73 -WRSQRPPAVKPKRR---------SKSSSLSSAGNAPPLPPKTRQNSIHSGQKDELDGQERHEEG 127

  Fly   813 ITKTTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPN-ENNRGAAAAGPGVFIESHQFTPM 876
            ::....         |.|:|.|.......|....:.|.:|. |.|.|...         ||..| 
Zfish   128 LSAADG---------GRSAPDGKEGSKQRSERESSPLPEPQCEKNCGCMC---------HQQRP- 173

  Fly   877 AGASSP-IPISLHSSHMHAAQSNDTQKEII--SMEDENSDL-----DEPFIDENGPFNNLTRLLE 933
             |.... :|||..|       ..:.::|::  |.||:|:.|     :|.|.:|...|:....::|
Zfish   174 -GMKLIWVPISEPS-------DEEEEEEVLSSSTEDQNTSLAEAENEETFKEEPVSFSKSLDVVE 230

  Fly   934 AEN-----VTFLA---IFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHSTFLVPRAP 990
            .:.     ..|||   :....:...|||.|..  |||                   |....|:.|
Zfish   231 TKQKAPQMKNFLAARNLIEQQLRRKSDPGPPA--LIT-------------------SVIPFPQTP 274

  Fly   991 LSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQKRTAGLGTIYGPT 1055
            ::           |.||..||..:..|.                          ...|..:..|.
Zfish   275 IN-----------VSNVQTLEVPEESIY--------------------------DVSLEVVTPPR 302

  Fly  1056 DDKLAEAKTDKLREQIIDKYLMPNLHALIEDENGSPPEDVRKVALCSALSTVIYRIFNTRPPPSS 1120
            ..|.|:..|.|                      .|||....::.|.:....:|.       ||| 
Zfish   303 PQKHADTGTGK----------------------DSPPAIPPRMPLDNRCPQIIL-------PPS- 337

  Fly  1121 IVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCK 1185
                    ::|..|                 ||:                     |.........
Zfish   338 --------LARPAS-----------------PLM---------------------PPKKRSPPAS 356

  Fly  1186 LNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPD 1250
            ..:.|         .|.|.|.||...:..:.|.:..|                            
Zfish   357 PRLQR---------TPPPPPPAKTYENGRRFSNYSLK---------------------------- 384

  Fly  1251 RGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLS 1315
                               ||..|.:|....||              :|::|.|           
Zfish   385 -------------------SIDENDSTEGEKSG--------------SNENIRP----------- 405

  Fly  1316 TSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARR-----ERYSQHPKHKSAPVSVNRSESYKE 1375
            ..:|:....                   :||.||..     :.|::...||....:|.|:.|   
Zfish   406 PRIATRRQK-------------------SVDLEAEMSDELYQFYTETYVHKEIRRTVCRNIS--- 448

  Fly  1376 RLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPG 1440
                        |||                   |.:..||..:.|...|.:.|.:|        
Zfish   449 ------------KTS-------------------ADFQMSSQITTSPEKGEKGPKSS-------- 474

  Fly  1441 AAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARW 1505
                   ....|.||                                    :.|.          
Zfish   475 -------ESQSLKQN------------------------------------NLWR---------- 486

  Fly  1506 TLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYE 1570
                         :.|::..:.||..|:..|.|.||.:.|:..:|.:::|:|::|...|    .|
Zfish   487 -------------EQSAVRDSGVLEKLSPEECKYQESMFEVITSEMSYLRSLRVLTEHF----VE 534

  Fly  1571 SGLLSQDHLLL----LFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVL 1631
            |..|::..:::    || ..::.::|:...|.:.|:: |::.|.:::.|.|::            
Zfish   535 SSELNETLIIMDKKTLF-SNIIRIQEVSERFLKDLEE-RLDENIIISDICDII------------ 585

  Fly  1632 CEFAAQ--FCARQQIALEALKEKRNKDEMLQK-------LLKKSESHKACRRLELKDLLPTVLQR 1687
             .:.||  |.|........:.:::....::|.       :.:..||.| |:||.....|....||
Zfish   586 -HYHAQHHFPAYIDYVRNQIYQEKTYSNLMQTNTQFATVITRLQESPK-CQRLPFMSFLLLPFQR 648

  Fly  1688 LTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDR 1752
            :|:..:|.||:.|.|.    ..|.:.:...:|::|..:|:.|.|..|...:...:|..|...|  
Zfish   649 ITRIKMLIENILKRTA----VGTDKEQTASKALDSVSKIIEECNTQVGKMKQMEELIQINGML-- 707

  Fly  1753 SSYDKEEFKKLD----LTQHHLIHD--------------GNLTIKKNPSVQLHGLLFENMIVLLT 1799
                  ||.||.    ::|...:..              |||..|..|   ::..||.:::|:..
Zfish   708 ------EFDKLKAVPIISQTRYLEKQGEVLEVNKGGTFLGNLRPKFTP---VYLFLFNDLLVIAI 763

  Fly  1800 KQDDKYY--LKNLHTPL----SITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQ--MLE- 1855
            |:..:.|  |.:.|..|    |..|..|..|               ::.|.|..::..|  .:| 
Zfish   764 KKSAERYVVLDHAHRSLVQVQSYENSAVPNI---------------EHCFCLTLLENHQGRQMER 813

  Fly  1856 -LRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISD---PALAAIPHSNTKESLELSTD 1916
             ::|||.|:.:.|...|        .|.....:...:....|   |.:..:.....|:|.||:.:
Zfish   814 IMKAPSQSDSQRWLAVF--------PNPDDPKNDQEEVIYEDWDCPQVQCVEQYVAKQSDELNLE 870

  Fly  1917 TVQ 1919
            ..:
Zfish   871 RTE 873

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710 20/128 (16%)
C1_1 1151..1202 CDD:278556 4/50 (8%)
RhoGEF 1539..1731 CDD:238091 45/204 (22%)
PH_RhoGEF 1770..1875 CDD:275411 27/128 (21%)
DUF2413 2242..>2378 CDD:287302
arhgef15bXP_009304999.1 RhoGEF 511..688 CDD:279015 43/200 (22%)
PH_ephexin 711..833 CDD:269929 30/147 (20%)
PH 724..830 CDD:278594 26/123 (21%)
SH3_ephexin1_like 852..906 CDD:212727 4/22 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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