DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and arhgef3l

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_005162130.1	Gene:	arhgef3l / 553761	ZFINID:	ZDB-GENE-050522-85	Length:	532	Species:	Danio rerio

Alignment Length:	484	Identity:	107/484 - (22%)
Similarity:	194/484 - (40%)	Gaps:	106/484 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1484 GSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEAD--WSSMVAAEVLAALTDAEKKRQEIINEI 1546
            |.|...:.||.....|||....:.:.........:.  ||..| ..:...|:..|.||||:|.|:
Zfish   106 GQSIQRSISFRTEARPLPPMPRSRQKASSFPRRRSSQLWSDTV-DNMSHELSTKEIKRQEVIYEL 169

  Fly  1547 YQTERNHVRTLKLLDRLFFLPLYESGLLSQ----------DHLLLLFPPALLSLREIHGAFEQSL 1601
            .|.|:..:..|.|:.::::.|:.:..::::          |.|:.|....|:.|..:.||
Zfish   170 TQGEKQLIEDLSLVKKVYYEPMLKLDIMTESELGQIFGTLDSLIPLHEDLLVRLEGLRGA----- 229

  Fly  1602 KQRRIEHNHVVNTIGDLLADMFDGQSGVVLC-EFAAQFCARQQIALEALKEKRNKDEMLQKLLKK 1665
                   ...|..:|..:.|.|.       | |....:|. .|:..:||.:::.:|:.:::.|:.
Zfish   230 -------EKTVQEVGPTMMDWFP-------CLEAYITYCC-NQVGAKALLDQKKQDKRVEQFLRL 279

  Fly  1666 SESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEV 1730
            .:.....|:|:|.:.|.....||.|||||.:.:.|.|    |.:..:.:|:.:|:|..:||:.||
Zfish   280 CQESSFSRKLDLWNFLDLPRSRLVKYPLLLKEIQKST----PLDHPDEDALPQAMELIQRIITEV 340

  Fly  1731 NQAVKT--------------AEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLIHDGNLTIKKN 1781
            |  :||              |||:.::..||  ..|..|...|                  :|..
Zfish   341 N--LKTGEAECQFYRRGLCYAEDSQRVAEIQ--ASRFLYCHGE------------------LKST 383

  Fly  1782 PSVQLHGLLFENMIVLLTK---QDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSF 1843
            ...:||..||| ::::||:   ||     :.......:..:|: |...:..:.|...|.:...||
Zfish   384 KGQKLHVFLFE-LVLVLTRPVAQD-----REGPVQFQVYRQPM-PAAHLHLEDLPDGEPSSSGSF 441

  Fly  1844 -------------FLIK---MKTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDT 1892
                         |.:.   ...||...|:|..|...:.|.........:....:::::..|.:.
Zfish   442 RGAFTGNDKVKNCFRVSTTGRSKSQSHSLQANDSFNKQQWISCLRQAMVQSRDRQAQSSPCNPNE 506

  Fly  1893 SIS-DPALAAIPHSNTKESLELSTDTVQP 1920
            .:| :|||    ::|..| |.:::|...|
Zfish   507 RLSPEPAL----YNNIAE-LTINSDVDMP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	49/202 (24%)
		PH_RhoGEF	1770..1875	CDD:275411	23/123 (19%)
		DUF2413	2242..>2378	CDD:287302
arhgef3l	XP_005162130.1	RhoGEF	165..341	CDD:279015	46/199 (23%)
arhgef3l	XP_005162130.1	PH_RhoGEF3_XPLN	355..489	CDD:269976	31/160 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580168
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840