DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and PLEKHG6

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001371533.1	Gene:	PLEKHG6 / 55200	HGNCID:	25562	Length:	806	Species:	Homo sapiens

Alignment Length:	769	Identity:	164/769 - (21%)
Similarity:	264/769 - (34%)	Gaps:	178/769 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1411 TYVGSSNSSLSSAGGS--------ESPSTSMEHFAAPGAAGGVQ---VPPMGLNQNQHPHLLIQQ 1464
            ||.|...:|..|..|.        ..||........|.|.|..|   :.||.| ::..|.   ::
Human    22 TYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRL-RDPEPE---KR 82

  Fly  1465 HAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWT--------LESEDED--DVNEAD 1519
            |           .|..| ||...:.........|.|.|...|        |..||..  ::.|..
Human    83 H-----------GGHVG-AGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGG 135

  Fly  1520 WSSMVAAEVLAALTDAEKK-------RQEIINEIYQTERNHVRTLKLLDRLF---FLPLYESGLL 1574
            .|.:...:....|....|:       :||.:.|:..||..:||.||::..|.   .|.|...|||
Human   136 DSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLL 200

  Fly  1575 SQDHLLLLF--PPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA-- 1635
            .:.....||  .|:|:   ..|.:|...:....:|.   ....|..| |....|||.:  .|.
Human   201 MEVSAETLFGNVPSLI---RTHRSFWDEVLGPTLEE---TRASGQPL-DPIGLQSGFL--TFGQR 256

  Fly  1636 ----AQFCARQQIALEALKEKRNKDEMLQKL----------------LKKSESHKACRRLELKDL 1680
                .|:|.|.:..:...:|::..:.:....                |:..|.||...|..|.||
Human   257 FHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQAGQEGANPEPHPPSLQWCEKHKRSGRQMLCDL 321

  Fly  1681 LPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQN 1745
            |....||:||||||...:.|.:    ||...: ||:...:|:.:..|..:|..|:..|:...|..
Human   322 LIKPHQRITKYPLLLHAVLKRS----PEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAA 381

  Fly  1746 IQRKL----------DRSSYDKEEFKKLDLT--------QH--HLIHDGNLTIK--KNPSVQLHG 1788
            ..:::          |....:...|..||||        :|  .|:.:|.:.:|  :...:.::.
Human   382 AAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYL 446

  Fly  1789 LLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMK---- 1849
            .||.:::::...|......|.:..||.:             :.|:.|...|.|||.||.:.
Human   447 FLFSDVLLVTKPQRKADKAKVIRPPLML-------------EKLVCQPLRDPNSFLLIHLTEFQC 498

  Fly  1850 TSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSK---------------NASSNHDTSISDPAL 1899
            .|..|.:..||.::...|.:......|...|.:::               ....:..|..|.|:|
Human   499 VSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSL 563

  Fly  1900 AAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATV-----TPAPATNNSNVSSLTGVQ 1959
            .....|....:.|.|| .:..|..|.  .|...||::|..|.     |..|.|...:.|.|:.::
Human   564 EGSQSSAEGRTPEFST-IIPHLVVTE--DTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLR 625

  Fly  1960 LRNPQRDATASESDADYVNTP-KPRSSQNEVNRTMSIRSTGEPIQKYSA--------------NG 2009
            .|..:||...:.|..:..:.| :|.....:..:..|.....|.|.|..:              ..
Human   626 QRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGA 690

  Fly  2010 TEANDVTLR----------------HSQSTRESVRPGSTGEERNSTYGMVGGNS 2047
            :|..:|.:.                |:.|..||....|..||......:..|::
Human   691 SERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHT 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	57/218 (26%)
		PH_RhoGEF	1770..1875	CDD:275411	22/110 (20%)
		DUF2413	2242..>2378	CDD:287302
PLEKHG6	NP_001371533.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..91		9/43 (21%)
		RhoGEF	165..367	CDD:395496	55/215 (26%)
		PH_PLEKHG5_G6	424..522	CDD:270064	22/110 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..693		30/150 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..746		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740