DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF2 and ARHGEF3

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001122087.1	Gene:	ARHGEF3 / 50650	HGNCID:	683	Length:	558	Species:	Homo sapiens

Alignment Length:	391	Identity:	96/391 - (24%)
Similarity:	159/391 - (40%)	Gaps:	76/391 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1520 WSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFP 1584
            ||......|...||..|.||||.|.|:.|.|.:.:..|||..:.:..|:.:..::::..|..:|
Human   136 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIF- 199

  Fly  1585 PALLSLREIHGAFEQSLKQRR--------IEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCAR 1641
            ..|.||..:|   |:.|.|.|        .||      :|.:|.       |.:.|..:......
Human   200 GTLDSLIPLH---EELLSQLRDVRKPDGSTEH------VGPILV-------GWLPCLSSYDSYCS 248

  Fly  1642 QQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLL 1706
            .|:|.:||.:.:.:|..:|..|::.......|:|:|.:.|.....||.|||||...:.:.|
Human   249 NQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHT---- 309

  Fly  1707 PENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLI 1771
            |.:..:.:.::.|:...:.|:.|:|  .||.|            ....|.||....|:..|...:
Human   310 PNDNPDQQHLEEAINIIQGIVAEIN--TKTGE------------SECRYYKERLLYLEEGQKDSL 360

  Fly  1772 HDGNLT------IKKNPSVQLHGLLFENMIVL---LTKQDDKYYLKNLHTPLSITNKPVSPIMSI 1827
            .|.:..      :|.|..|:||..||:.::|:   :|..:...| :....|:     ||..::..
Human   361 IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCY-QLYRQPI-----PVKDLLLE 419

  Fly  1828 D-ADTLIR-----QEAADKN----SFFLIKMKT---SQMLELRAPSSSECKTWFKHFSDVAARQS 1879
            | .|..:|     :.|...|    :||.:..|.   ||...|:|..:...:.|..     ..||:
Human   420 DLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLN-----CIRQA 479

  Fly  1880 K 1880
            |
Human   480 K 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	50/199 (25%)
		PH_RhoGEF	1770..1875	CDD:275411	27/126 (21%)
		DUF2413	2242..>2378	CDD:287302
ARHGEF3	NP_001122087.1	RhoGEF	158..334	CDD:395496	47/196 (24%)
ARHGEF3	NP_001122087.1	PH_RhoGEF3_XPLN	348..480	CDD:269976	31/142 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810