DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and ITSN2

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_006268.2 Gene:ITSN2 / 50618 HGNCID:6184 Length:1697 Species:Homo sapiens


Alignment Length:1743 Identity:312/1743 - (17%)
Similarity:550/1743 - (31%) Gaps:604/1743 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   578 KNKFLISRSLIE-----EDVP---PPLPQRNPPRQLNLDLKNGNAS------PGGSHLVAPVSDL 628
            :.:|.|:..||:     :.:|   ||:.::.|.....:..:.|..|      |......||::.|
Human    76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPITSL 140

  Fly   629 DRATS----PQLNRSQQQQLPS-STDNSPSNAKSKRSKIKTKALSDP-----KMSTQMFLQMESA 683
            ..|||    |.| ......:|| ||.:.|:.         |.:|..|     ..||.......|.
Human   141 SSATSGTNLPPL-MMPTPLVPSVSTSSLPNG---------TASLIQPLPIPYSSSTLPHGSSYSL 195

  Fly   684 SAAGAAGGSIE-----VDGGPPPLPPRLPGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAV 743
            ...|..|.||:     :|.|                |..|..:.|..:.     |.|...|:   
Human   196 MMGGFGGASIQKAQSLIDLG----------------SSSSTSSTASLSG-----NSPKTGTS--- 236

  Fly   744 QNDNLNIAFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPR 808
                 ..|.|...|....|:.....:.....:||.||..||.|: ||.:.:...:          
Human   237 -----EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQS-NLSQTQLATI---------- 285

  Fly   809 HPDRITKTTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPNENNRGAAAAGPGVFIESHQF 873
                        |.:.:.||:..         |.:..                     ||.:...
Human   286 ------------WTLADVDGDGQ---------LKAEE---------------------FILAMHL 308

  Fly   874 TPMAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVT 938
            |.||.|..|:|::|....:..:.....|.:.|                ||...:..::.|.|...
Human   309 TDMAKAGQPLPLTLPPELVPPSFRGGKQIDSI----------------NGTLPSYQKMQEEEPQK 357

  Fly   939 FLAIFL------NYVISNSDPAPLLFYLITELYKEGTSKDMR---------------KWAYEIH- 981
            .|.:..      ||...|.:.......|:.:..:|...|..:               :|..::. 
Human   358 KLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLEL 422

  Fly   982 STFLVPRAPLSWYRQD---------ESLAREVDNVLQLEYDKV--------------EILRTVFL 1023
            ...|..:..|...|::         |:..:|::...:||::::              ||:|   |
Human   423 EKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVR---L 484

  Fly  1024 RSRKRAKDLISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLREQIIDK-------------- 1074
            .|:|:...|..|.|....|:       |.|...|...:.:|.|...:::||              
Human   485 NSKKKNLHLELEALNGKHQQ-------ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQ 542

  Fly  1075 ----------YLMPNLHALIE-----DENGSPPEDV--------RKVALCSALSTVIYRIFNTRP 1116
                      ||:|....|.|     ..:.:|...|        .|..||..|...:        
Human   543 ELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQL-------- 599

  Fly  1117 PPSSIVERVHHFVSRDKSFKSR-------------------------IMGKNRKMNVRGHPLVLR 1156
              .::.:.....:|...||.::                         ::.|..:.......|.|.
Human   600 --DALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALE 662

  Fly  1157 QYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHR------QCSKVVDESCPGPLPQAKRLAHNDK 1215
            |.|::..                   |....|.|      |..|:.||        |.|.|...|
Human   663 QLYKIKR-------------------DKLKEIERKRLELMQKKKLEDE--------AARKAKQGK 700

  Fly  1216 ISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSD---------RRPDANISI 1271
            .:.:...:|...     .||:.|..||...|...:..:.:..:|..|         :|..|::.:
Human   701 ENLWKENLRKEE-----EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLV 760

  Fly  1272 ----------RSNGNTSCNTSGLNTTD---------LQSSFHGSCANDSINPGGGAGCN------ 1311
                      |::...|.|:..:...|         |..||.|:.        |...||      
Human   761 NYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNF--------GWFPCNYVEKMP 817

  Fly  1312 ------------------MDLSTSVASTTPSTSGSVAA-------------------GLSAFA-- 1337
                              :.||.:..|:.|.:|...|:                   ..|||.  
Human   818 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT 882

  Fly  1338 -----------------ELNALDTVDKEARRERYSQHPKHKSAPVSVNRS--------------- 1370
                             .|.|.......|:::.:....||....|...:.               
Human   883 VSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFP 947

  Fly  1371 ESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLG---LSNATYVGSSNSSLSSAGGSE----- 1427
            :||.:.:.....:....:....:::.:|......:|   ::...|.......|:...|.|     
Human   948 KSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQ 1012

  Fly  1428 ----------------SPST-----SMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQ 1471
                            .||.     ..|.|.:...:|.         .|:.|.  |.|....|..
Human  1013 KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGA---------SNKKPE--IAQVTSAYVA 1066

  Fly  1472 QDSFQAGLA-GAAGSSAASNSSFWNAG---------------------------------HPL-- 1500
            ..|.|..|| |........|:|.|..|                                 ||:  
Human  1067 SGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQ 1131

  Fly  1501 PVARWTLESEDEDDV-------------NEADW--------SSMVAAEVLAALTDA--------- 1535
            .:|.:...:.:||::             ::.||        :.:..:..:...||:         
Human  1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCAD 1196

  Fly  1536 ----------EKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSL 1590
                      |:|||..|:|:.|||..::..|:|:..:|...:.|||.|::..:.|:|    ::.
Human  1197 LQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIF----VNW 1257

  Fly  1591 REIHGAFEQSLKQRRIE-----HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALK 1650
            :|:..:..:.||..|:.     ....|..|||:||.........:      :||:.|......|:
Human  1258 KELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYI------RFCSCQLNGAALLQ 1316

  Fly  1651 EKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEA 1715
            :|.::|...::.|||..|...|:.:.|...|...:||:|:||||..::.:.|    ||:..:..:
Human  1317 QKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENT----PESHADHSS 1377

  Fly  1716 IQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKE-EFKKLD--LTQHHLIHDGNLT 1777
            ::.|:|.::.:..:||:.|:..|::.:|:.||..:......:: .|..|.  |....|:|.|.| 
Human  1378 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKL- 1441

  Fly  1778 IKKNPSVQLHGLLFENMIVL--LTKQ------DDKYY-------LKNLHTPLSI----------- 1816
            .|...:.:|||.||.:.::|  :.||      .:|.:       .|...||:.:           
Human  1442 YKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDP 1506

  Fly  1817 -TNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTS-------------QMLELRAPSSSECKTW 1867
             :::||..|..||....:|.:..::.:.::.|:|.:             :..:.|:..:|.....
Human  1507 SSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRL 1571

  Fly  1868 FKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQP 1920
            ..|.  :.|.:.|....|..||....||..:     .|.|..:::   ||:.|
Human  1572 MVHV--IEATELKACKPNGKSNPYCEISMGS-----QSYTTRTIQ---DTLNP 1614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710 28/165 (17%)
C1_1 1151..1202 CDD:278556 11/56 (20%)
RhoGEF 1539..1731 CDD:238091 51/196 (26%)
PH_RhoGEF 1770..1875 CDD:275411 28/144 (19%)
DUF2413 2242..>2378 CDD:287302
ITSN2NP_006268.2 SH3_Intersectin2_4 1057..1115 CDD:212927 12/57 (21%)
SH3_Intersectin2_5 1130..1183 CDD:212929 5/52 (10%)
RhoGEF 1214..1394 CDD:214619 50/193 (26%)
PH_13 1412..1554 CDD:318790 28/142 (20%)
C2_Intersectin 1555..1689 CDD:176021 15/70 (21%)
EH 15..107 CDD:197477 7/30 (23%)
SOBP <90..182 CDD:317654 23/101 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..241 6/34 (18%)
EH 237..316 CDD:197477 23/131 (18%)
Neuromodulin_N <346..756 CDD:331332 74/461 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..378 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..752 14/73 (19%)
SH3_Intersectin2_1 759..815 CDD:212921 11/63 (17%)
INTAP 815..902 CDD:318758 9/86 (10%)
SH3_Intersectin2_2 902..953 CDD:212923 7/50 (14%)
SH3_Intersectin2_3 985..1036 CDD:212925 6/50 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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