DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and net1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_021330686.1 Gene:net1 / 493607 ZFINID:ZDB-GENE-041121-18 Length:605 Species:Danio rerio


Alignment Length:497 Identity:108/497 - (21%)
Similarity:212/497 - (42%) Gaps:72/497 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  1516 NEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLL 1580
            |...||..:........:..|.||||.|.|:.:.|::.:..|||..:.:..|:.:..::|::.|.
Zfish   151 NSTLWSETLDVHQKGTFSTKEIKRQEAIFELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELT 215

  Fly  1581 LLFP--PALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQ 1643
            .:|.  .|.:.|.|  ...:|..|....:  ..|..||.::.|....     |..:.| :|: .|
Zfish   216 AIFGDLDAYIPLHE--DLLDQLAKATGTD--GTVRQIGKIVVDWLPR-----LNAYRA-YCS-NQ 269

  Fly  1644 IALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPE 1708
            :|.:||.:::.:|..:|..|::.......|:|:|...|.....||.|||||.:.:.:.|    |.
Zfish   270 LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHT----PP 330

  Fly  1709 NTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY--DKEEFKKLDLTQHHLI 1771
            :..:..::::|:...:.:|.::|  :|..|     ...|..:|:..|  ||::..:::..:..|.
Zfish   331 DHPDKGSLEQAISVIQAVLADIN--MKKGE-----SECQYYIDKLEYLEDKQKDPRIEQCKSLLC 388

  Fly  1772 HDGNLTIKKNPSVQLHGLLFENMIVLL--TKQDDKYYLKNLHTPLSITNKPVSPIMSID-ADTLI 1833
            | |.|  :.....:||..||..:::|.  ..::|::..:....|:     ||..::..| .|..:
Zfish   389 H-GEL--RNKSGTKLHVFLFTEVLILTRPVTRNDRHCFQVYRQPI-----PVQDLVLEDLQDGDV 445

  Fly  1834 RQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHFSDVAARQS-KNRSKNA-SSNHDTSISD 1896
            |...:.:.:|.... |...:..:|...:|:.::.....:||..:|. .|..:|| |:..|.::|:
Zfish   446 RMGGSFRGAFSNAD-KAKNIFRVRFQDASQGQSHTLQVNDVFHKQQWLNCLRNAMSTQKDLTLSE 509

  Fly  1897 PALAAIPHSNT---KESLELST-------DTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSN 1951
            ......|.::.   :.|..:||       |...|.||.:       ||..|.:...|:|..:.::
Zfish   510 NEPLTTPATDVCAKRRSSSVSTVIQMDEMDENCPRAAAS-------APSSPSSEEPPSPTPSATS 567

  Fly  1952 VSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTM 1993
            ..|               |.|.:..::.|.|.....:..|::
Zfish   568 TLS---------------SSSSSSSISAPIPSRKSKKDKRSL 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 47/193 (24%)
PH_RhoGEF 1770..1875 CDD:275411 21/107 (20%)
DUF2413 2242..>2378 CDD:287302
net1XP_021330686.1 RhoGEF 177..353 CDD:214619 44/190 (23%)
PH-like 367..500 CDD:327399 29/141 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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