DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and itsn2b

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_005158835.1 Gene:itsn2b / 445153 ZFINID:ZDB-GENE-050309-102 Length:1837 Species:Danio rerio


Alignment Length:2067 Identity:354/2067 - (17%)
Similarity:630/2067 - (30%) Gaps:708/2067 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 QEIPEESSI---QPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAGAPQSPVIVVDSV--PEL 83
            |.:|....|   |||..:.:..:......:.|.....|......|...|..||:.|:..:  ..|
Zfish    85 QNLPTALPIIMKQPPVPAPTMPAAPLGMGAMPNVPMMPNVPILTPIPIATMSPIPVMTPMMGTGL 149

  Fly    84 PAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLASSLSSLASSLSGHRDRDKDRDKDRENQNAVPP 148
            |.....::.:.........:...|.:|.:.:|..|.|..||                        
Zfish   150 PVSMMPTISSQTLPNGPIAILQPSPMPLTSTLPLSSSFSAS------------------------ 190

  Fly   149 QTPPLPPSYKQNQMNGDSTAAAGGGVSAPATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQ 213
                 |..:....||..|:....|..|:.::|:|:..:|:.....|..|             |.|
Zfish   191 -----PLGFSTTSMNKTSSLLDLGSSSSNSSPSTSLASNSPKGGPSDWG-------------VPQ 237

  Fly   214 APGERSSLNLTPLSRDLSGGHT--QESTTPATTPSTPS-LALPKNFQYLTLTVRKDSNGYGMKVS 275
            |...:.......|.:.:||..|  |..|..|||..|.: ||...|.    ..|.||.     |:.
Zfish   238 ASRLKYRQQFNSLDKLMSGYLTGPQVRTAMATTLLTQTQLAAIWNL----ADVDKDG-----KLK 293

  Fly   276 GDNPV----FVESVKPGGAAEIAGLVAGDMI---LRVNGHEVRLEKHPTV-VGLI---------- 322
            .|..:    .|:..|.|....:|  :..|::   ||....|......|:: .||.          
Zfish   294 ADEFILAMHLVDMAKMGQPLPLA--LPSDLVPPSLRGKLGESMNGTTPSIYAGLAEDLCEPEPPQ 356

  Fly   323 --KASTTVELAVKRSQKLTRPSSVSVVTPSTPILSGRDRTASITGPQPV-DSIKRREMETYKIQT 384
              :.:.|.|...|::.:|..    :.:.....:|..:.|.......|.. :..:|||.|..:::.
Zfish   357 KSRNNLTFEDKFKKNMELGN----AELEKRRQVLQEQQRREEERRAQKAREEQERREREARELEL 417

  Fly   385 LQKMLEQEKL----NLERLKSDQNNPSYKLSEANIRKLREQ-------------LHQVGAEDAPT 432
            .:|..|:.:|    .|||.:.::.....:..||..::|..|             .:|...|....
Zfish   418 KRKREEEIRLERQRELERQREEERLKELERKEAAKKELERQQQLEWERRRKQELQNQKSEEQEDI 482

  Fly   433 VKLQA----------AAGNKNTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPA 487
            :||:|          |.|||...:                :.:.........:|.|......|..
Zfish   483 IKLRAKKRSLEMELEAVGNKQKQI----------------SDKLRDAQGRKRIHKNELEMINQKR 531

  Fly   488 STSPAFLSLLPRSLSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMHQHTST 552
            .:....:|.|.:.|...     |.|          .|.:|.  :||:::.:..|:|.:     |.
Zfish   532 DSCITEISSLQKQLEDF-----KRK----------LGQSTS--EQQKLTDKLRSLSLN-----SV 574

  Fly   553 PTSQQFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPG 617
            ||:                  |.|     .:..::.|:|    |..|....|||...|       
Zfish   575 PTA------------------TVK-----TLQNNMEEKD----LSCRKLKEQLNAVEK------- 605

  Fly   618 GSHLVAPVSDLD--RATSPQLNRSQQQQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQM 680
              ...|.::|:|  :.....|..||:.|         .:|..|...||.:.:.:.|...|     
Zfish   606 --ETAAKLADMDQYKKDIQDLRESQRMQ---------ESALEKLRTIKEEKIRELKKRKQ----- 654

  Fly   681 ESASAAGAAGGSIEVDGGPPPLPPRLPGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQN 745
                                                                             
Zfish   655 ----------------------------------------------------------------- 654

  Fly   746 DNLNIAFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHP 810
                            ::|::.:::::.|                                    
Zfish   655 ----------------EELEKKRREEEEQ------------------------------------ 667

  Fly   811 DRITKTTSGSW-EIVEKDGESSPPGTPPPPYLSSSHMTVLEDPNENNRGAAAAGPGVFIESHQFT 874
            .||.......| |.:.:|.|..      ...:.......|.:..|..|.|               
Zfish   668 KRIKLEKERQWQEKLRRDEEEK------QRKIQEERDAKLREEEERERQA--------------- 711

  Fly   875 PMAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVTF 939
                            .:.||:....::.....|:|....:|    |........|.||.|    
Zfish   712 ----------------RLQAAKEQAERERKAREEEERRRREE----EEERREQERRRLEEE---- 752

  Fly   940 LAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREV 1004
                                            |.|                    |:||...:  
Zfish   753 --------------------------------DRR--------------------RRDEERRK-- 763

  Fly  1005 DNVLQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLRE 1069
               |:.|..|:|..|......|||.:::..::.||.:::|.|          ::....|.::.||
Zfish   764 ---LEEERRKLEEERRKLEDERKRQEEIRLKEEREREERRRA----------EEERRRKEEERRE 815

  Fly  1070 QIIDKYLMPNLHALIEDENGSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKS 1134
            :              |.:.....|:.|:                         .|......||..
Zfish   816 E--------------ERKREREEEERRR-------------------------HRAQEAAMRDAE 841

  Fly  1135 FKSRI-MGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDE 1198
            .:.|| ..:.||...|      |:..|.......:             ...|.:..|:..:..:|
Zfish   842 ERKRIEEERKRKEEER------RKQEEEDRRRREE-------------EQRKQDEERKRKQQQEE 887

  Fly  1199 SCPGPL----PQAKRLAHNDKISKFM-------GKIRPRTSDVIGNEKR---------------S 1237
            :....|    ...|....:|.:|..:       |..||     :|.:.|               :
Zfish   888 AAAARLRDDEQNKKNTVKSDLVSALLRGLEERKGGRRP-----LGTQHRRSAALTTFKALYPFTA 947

  Fly  1238 RQDEELDVELT---------------------------PD-------RGQASIVRQPSDRRPDAN 1268
            |.:|||..|..                           |:       :.:|.:|.:.: .:|..:
Zfish   948 RNEEELSFESDDLIEVDESVEREQGWLYGSWQGKMGWFPESYVEKQTKSEAPVVAKQA-LKPQVS 1011

  Fly  1269 ISIR----SNGNTSCNTSGLNT--TDLQSSFHGSCANDSINPGGGAGCNMDLST----------- 1316
            ||:.    ..|.:..|::...|  |...||.||....   |....|.|:....|           
Zfish  1012 ISVSKLSDGPGGSRLNSAFTPTHATGSTSSNHGQVVG---NVQAQALCSWSAKTDNHLDFSKDDV 1073

  Fly  1317 ----------------SVASTTPSTSGSVAAGLSAFAE-LNALDTVDKEARRERYSQHPKHKSAP 1364
                            .|....|.|..:|.:...|.|: .:|.||.|.....|..:.:......|
Zfish  1074 ITVLEQQENWWLGELDGVQGWFPKTYVTVLSTSDAQADSTDASDTTDGSNYEEYVALYTYESPEP 1138

  Fly  1365 VSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYV---GSSNSSLSSAGGS 1426
            ..:..:|.....:|.:.....|....|.:            ||..:.||   .:..||||...|:
Zfish  1139 GDLTFNEGDTILVSEREGEWWRGSIGDRA------------GLFPSNYVKPKETDTSSLSGKSGT 1191

  Fly  1427 ESPSTSMEHFAAPGAAGGVQ---VPP----MGLNQNQHPHLLIQQHAQ-QYCQQDSFQAGLAGAA 1483
            ......:........|.|.:   :.|    :.||:|.....|.:..|: :..|:..|.|......
Zfish  1192 PGKKPEVAQVTTACTAAGAEQLNLSPGQLILILNKNPSGWWLGELQARGKKRQKGWFPASHVKLL 1256

  Fly  1484 GS-SAASNSSFWNAGHPLPVARWTLESEDE-----------DDVNEADW--------SSMVAAEV 1528
            || |..|..:..:.|..:.:..:|..:|||           .|.:..||        :.::....
Zfish  1257 GSNSGKSTPATPSVGQVIAIYDYTAANEDELSFSKSQVINVLDKSNPDWWKGELNGVTGLIPTNY 1321

  Fly  1529 LAALTDA-------------------EKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLL 1574
            :...||:                   ::|||:.|:|:..||..:|..|:|:..:|:.|:.||..|
Zfish  1322 VKLTTDSDPSQQWCADQSTLESMSPKDRKRQDYIHELIDTEEKYVEDLQLVLEVFYKPMSESNRL 1386

  Fly  1575 SQDHLLLLFPPALLSLREIHGAFEQSLKQRRIE-----HNHVVNTIGDLLADMFDGQSGVVLCEF 1634
            |:..:.::|    .:.||:.....:.||..:..     .|..|:.|||:|..........:    
Zfish  1387 SEAEMNMIF----ANWRELIQCSSKMLKALKARKKSGGDNMPVHMIGDILTSELSNMQAYI---- 1443

  Fly  1635 AAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLY 1699
              :||:.|......|:::.:::...:..|||..:...|:.:.|...|...:||:|:|||..:::.
Zfish  1444 --RFCSCQLEGAALLQQRTDQEPDFKTFLKKIATDYRCKGMPLSSFLLKPMQRITRYPLHIKHIL 1506

  Fly  1700 KVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLD-RSSYDKEEFKKL 1763
            :.|    ||:..:...:..|:|.::.:..|||:.|:..|::.:|:.||..:. ....:...|..:
Zfish  1507 ENT----PESHVDYIQLTEALEKAELLCFEVNEGVREKENSDRLEWIQSHVQCEGIAENLIFNSM 1567

  Fly  1764 D--LTQHHLIHDGNLTIKKNPSVQLHGLLFENMIV---------------LLTKQDDKYYLKNLH 1811
            .  |....|:|.|.: .|...:.:||..||.:.::               |.:.:.:..| |...
Zfish  1568 TNCLGPRKLLHSGKV-FKMKSNKELHAFLFSDFLLFTQAVRQFTSSGTDKLFSPKSNTQY-KMYK 1630

  Fly  1812 TPLSI------------TNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTS 1851
            ||:.:            :::||..|..||....::.|..::.:.::.|:|.:
Zfish  1631 TPVFLNEVLVKLPSDPSSDEPVFHISHIDRVYTLKTENINERTAWVQKIKVA 1682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 18/93 (19%)
RGS_GEF_like 934..1055 CDD:188710 18/120 (15%)
C1_1 1151..1202 CDD:278556 5/50 (10%)
RhoGEF 1539..1731 CDD:238091 48/196 (24%)
PH_RhoGEF 1770..1875 CDD:275411 21/109 (19%)
DUF2413 2242..>2378 CDD:287302
itsn2bXP_005158835.1 EH 7..99 CDD:197477 4/13 (31%)
EH 19..83 CDD:238009
Amelogenin <80..183 CDD:197891 18/97 (19%)
EH 232..327 CDD:197477 27/118 (23%)
EH 243..308 CDD:238009 19/73 (26%)
TAF4 <453..592 CDD:296797 32/203 (16%)
DUF4349 <559..691 CDD:305044 38/309 (12%)
SH3 936..992 CDD:302595 6/55 (11%)
SH3 1051..1102 CDD:302595 6/50 (12%)
SH3_Intersectin_3 1126..1177 CDD:212772 10/62 (16%)
SH3_Intersectin2_4 1198..1256 CDD:212927 11/57 (19%)
SH3_Intersectin2_5 1271..1324 CDD:212929 8/52 (15%)
RhoGEF 1355..1535 CDD:279015 47/193 (24%)
PH_ITSN 1562..1692 CDD:270084 23/123 (19%)
PH 1576..1684 CDD:278594 21/109 (19%)
C2_Intersectin 1695..1829 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.