DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and Arhgef15

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_011247414.1 Gene:Arhgef15 / 442801 MGIID:3045246 Length:877 Species:Mus musculus


Alignment Length:1049 Identity:199/1049 - (18%)
Similarity:337/1049 - (32%) Gaps:328/1049 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1110 RIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIW-- 1172
            ||...|||            ||.::..|     ...::....|..|.|.......:.|.:|.|  
Mouse    18 RIIRPRPP------------SRHRAPHS-----PGPLHNGSSPKALPQISNDASASVCTSIFWEP 65

  Fly  1173 --------GVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRP---- 1225
                    .:.|.....|    ::..|.|.....|.|.|.|.::|     .||.......|    
Mouse    66 PTASLKPPALLPPSVSRT----SLDSQTSPDSPSSTPSPSPVSRR-----SISPEPAPCSPVPPP 121

  Fly  1226 ------RT-------------SDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISI 1271
                  ||             :...|..:|.....|...|     |:|    |.||     ::..
Mouse   122 KPSGSSRTPLPSGPTPLQDGSASAPGTVRRLAGKFEWGAE-----GKA----QSSD-----SLER 172

  Fly  1272 RSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAF 1336
            .|.|:|..|  |...|. :::..|:.:.::..|.....|        ....|........||   
Mouse   173 CSQGSTEVN--GEKETP-EAALSGNGSQENGTPDAALAC--------PPCCPCVCHVAKPGL--- 223

  Fly  1337 AELNALDTVDKE-------------ARRERYS----QHPKHKSAPVSVNRSESYKERLSNKRNRN 1384
             ||..:.....|             |.|.|.:    .||     ||.:.   ||:.        .
Mouse   224 -ELRWVPVGSSEDILRIPCRASPLRASRSRINPPVISHP-----PVVLT---SYRS--------T 271

  Fly  1385 SRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPP 1449
            :.||...|....:|...:.|  :|.:..:...:..|.|..|.::.:.:.|.....||.  :..||
Mouse   272 AERKLLPPLKPPKPTKVRQD--ISTSEELPQPDLKLPSEDGIQTATKAWEGDRPEGAP--LNAPP 332

  Fly  1450 MGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAG----------------SSAASNSSFWNAGH 1498
            :.|...:                   :.||.|..|                .:|..:...|..|.
Mouse   333 VALEGRE-------------------EEGLDGLKGLQWELPLQDEPLYQTYRAAVLSEELWGVGE 378

  Fly  1499 P----------------LPVARWTLESEDEDDVNEADWSSMVAAE---VLAALTDAEKKRQEIIN 1544
            .                ||..|.||            |..:.|..   :|.:|:..|::.||.:.
Mouse   379 DGGPSPANPGEAPTFSRLPGPRNTL------------WQELPAVRGSGLLESLSPQERRMQESLF 431

  Fly  1545 EIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPAL---LSLREIHGAFE-----QSL 1601
            |:..:|.:::|:|:||...|        :|||         ||   |:.|:.|..|.     ||:
Mouse   432 EVVTSEASYLRSLRLLTDTF--------VLSQ---------ALRDTLTPRDHHTLFSNVQRVQSV 479

  Fly  1602 KQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA-----------AQFCARQQIALEALKEKRNK 1655
            .:|         .:|.||:.:........||:..           ..:...||...|......:.
Mouse   480 SER---------FLGTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDT 535

  Fly  1656 DEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAV 1720
            :......|::.:|...|.||.|...|....||:|:..:|.:|:...|    .|.::..|..|:|:
Mouse   536 NVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQT----EEGSSRQENAQKAL 596

  Fly  1721 ESSKRIL----VEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLIHDGNLTIKKN 1781
            .:..:|:    .||.:..:|.|       :.|...|..:.|.:...|......|...|.||   .
Mouse   597 GAVSKIIERCSAEVGRMKQTEE-------LIRLTQRLRFHKVKALPLVSWSRRLELQGELT---E 651

  Fly  1782 PSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLI 1846
            ...:..|:||.:              :...|||.:.         :.:|.|:           :.
Mouse   652 LGCRRGGVLFTS--------------RPRFTPLCLL---------LFSDLLL-----------IT 682

  Fly  1847 KMKTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRS------KNASSNHDTSISDPALAAIPHS 1905
            :.|:.|.|::..         :.|.|.|.|:|..:.|      .:..|||.   ..|....:..:
Mouse   683 QPKSGQRLQVLD---------YAHRSLVQAQQVPDPSGPPTFRLSLLSNHQ---GRPTHRLLQAA 735

  Fly  1906 NTKESLELSTDTVQPLAA----TATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRN---- 1962
            :...||..:.:...||.:    |.:....|..|.:|.    |.|.|.:....|:....:::    
Mouse   736 SLSVSLRPTMNPPHPLCSPLDQTCSAGWEPSPPQVPF----PVPQTPSMRTVSVPRSYVQSHPHL 796

  Fly  1963 PQ-RDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEP-----IQKYSANGTE----ANDVTL 2017
            |: |....|....:.:.|...:.|:..|:...::.|...|     .|::.|.||:    .::..:
Mouse   797 PRLRGKVWSPRPPESICTRIQKHSRWHVSHGSTLCSKNNPRQTPRKQRWRACGTKKSVLLHEAPV 861

  Fly  2018 RHSQSTRES 2026
            ...:::|.|
Mouse   862 NAMEASRSS 870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556 11/60 (18%)
RhoGEF 1539..1731 CDD:238091 48/214 (22%)
PH_RhoGEF 1770..1875 CDD:275411 17/104 (16%)
DUF2413 2242..>2378 CDD:287302
Arhgef15XP_011247414.1 RhoGEF 430..606 CDD:214619 45/205 (22%)
PH_ephexin 630..750 CDD:269929 29/168 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.