DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and Exn

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster


Alignment Length:2155 Identity:413/2155 - (19%)
Similarity:734/2155 - (34%) Gaps:703/2155 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 SAGAPQ--SPVIVVDSVPELPAPKQ--KSV-------KNSKS-KQKQKQLANKSKIPRSPSLASS 118
            ||...|  |||....|...|...|:  |||       .||:. ...:|.||.:         |:|
  Fly   120 SASEDQCHSPVHCHTSSSSLGTLKKLNKSVSCLVNAFNNSRDCATPEKTLAKR---------AAS 175

  Fly   119 LSSLASSLSGHRDRDKDRDKDRENQNAVPPQTPPLPPSYKQNQMNGDSTAAAGGGVSAPATPTTA 183
            |.:|..|.:.|:...:::|...:.:||            :|.:|.....::|...: ..|:.|.|
  Fly   176 LHNLQDSQAKHKQLHREKDNFYKYKNA------------EQAKMQAKLRSSADEAI-LNASETRA 227

  Fly   184 NNNNA-------SHNNGSI--------MGGGVQLNQSDNSNPVLQAPGE-------------RSS 220
            ..:::       |:|:.::        :..|....|.....||.:|..|             ...
  Fly   228 KRDDSGCLPGVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRAKREHNRLEG 292

  Fly   221 LNLTPLSRDLSGGHT---QESTTPATTPSTPSLALP------------------KNFQYLTLTVR 264
            |:|:..|.. |||.:   |.:||.::||:|.|....                  |::.......|
  Fly   293 LSLSAASAQ-SGGSSESLQTTTTSSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHHHPSR 356

  Fly   265 KDSNGYGMKVSGDNPVFVESVKPGGAAEIAGLVAG------------DMILRVNG-------HEV 310
            :.||     :...|         ||.:.:|.|...            :.:.|.||       |..
  Fly   357 RTSN-----MDSSN---------GGISMVAKLTHQFNEIIQKDAKLLEQVKRNNGVWISRGTHVY 407

  Fly   311 RLEKHPTV--VGLIKAS----TTVELAVKRSQKLTRPS----SVSVVTPSTPILSGRDRTASIT- 364
            ::.:.||.  .||..|.    :||:..:|:.::|.:||    |..::.....::.|    :|:: 
  Fly   408 KIVEKPTSEGKGLPNADDNRISTVQRNIKKFERLEKPSVPLKSEQLMRKHLELMRG----SSLSR 468

  Fly   365 GPQ-------PVDSIKRREM----ETYKIQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKL 418
            ||:       |..|:...|:    |..|..|.::..::.| :::. :|..|:|            
  Fly   469 GPRIKRNLKLPPGSVGIPELAIVSEELKTPTSEEQAKKPK-SVQN-ESQPNHP------------ 519

  Fly   419 REQLHQVGAEDAPTVKLQAAAGNK-NTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPP 482
             |:|:|  :.|.|:.:|....|.: :...|...|.:|..|| .:...:|            .:..
  Fly   520 -EELNQ--SNDKPSDELDLIMGEEGDEEELRQKQRKHKYAS-IYEKLRF------------TFAK 568

  Fly   483 QQQPASTSPAFLSLLPRSLSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMH 547
            .::.||.||....:  |...|:...:.|:.|.:|:.|... ..|.|.  .:.:..:||.:..|.|
  Fly   569 GRKSASPSPTKAQI--REEVSIDEESIKDSTSEDMVTRKE-DFTLDL--PKEVIPRAEDLEDSSH 628

  Fly   548 QHTSTPTSQQFFHPHQQQHRFKETGPTSKGKNKFLISRSLIE--EDVPPPLPQRNPPRQLNLDLK 610
            ....:|.                          |.....:::  |.|...|...||       |.
  Fly   629 ALLVSPC--------------------------FEADAKILDALEAVDLKLKVLNP-------LN 660

  Fly   611 NGNASPGGSHLVAPVSDLDRATSPQLNRSQQQQLPSST------DNSPSNAKSKRSKIKTKALSD 669
            :...:.|...|:...:|          ..:|:.||:|:      :...||.:...::.....|.:
  Fly   661 DVTTADGERELLLAAND----------DFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVN 715

  Fly   670 PKMSTQMFLQ--------------------MESASAAGAAGGSIEVDGGPPPLPPRLPGMMTEDM 714
            .....||.::                    ::.|..:.....::|.:....|:.|.:....||  
  Fly   716 AIEGEQMIMEQKQLMKVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTE-- 778

  Fly   715 SRGSCQNLAQPNSVGTAFNYPLVSTTTAVQND---NLNIAFPLSQRPNIVQQLQQYQQQQQHQMS 776
                    ||.:|:     :.:.:..:.:..|   .:..|..:..:||  ..|:.|:     .::
  Fly   779 --------AQTSSL-----FKIYTKKSELVEDIYQTVEEASTVEVKPN--NWLEGYE-----SIA 823

  Fly   777 GGQ--------------------------ATGALG-----QTPNLGKNKHRRVGSSPDNMHPRHP 810
            |.|                          |||.||     :.|.|.|.| |.:..||..:.|..|
  Fly   824 GSQEACPLTYDGYESFAPEEVVTTPTTPSATGTLGRNTRDELPELPKPK-RVLNKSPIPLRPAPP 887

  Fly   811 ----------DRITKTTSGSWEIVE-KDGESSPPG----TPPPPYLSS------SHMTVLEDPNE 854
                      :.|..|..|.:|.:. |...||..|    |.....|||      ||:........
  Fly   888 KPQAKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATT 952

  Fly   855 NNRGAAAAGPGVFIESHQFT---------------PMAGASSPI----PISLHSSHMHAAQSNDT 900
            .|:|..:||..:.:.|...|               .:|.|...:    .:...||...:|.|.|:
  Fly   953 QNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDS 1017

  Fly   901 -----QKEIISMEDENSDLDEPFID-ENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFY 959
                 ::..|:...:|||   .::| .:|.....|....|....|:                   
  Fly  1018 GKPGDKRSSIAGSSDNSD---AWVDISDGEIGQATTDATANEAQFI------------------- 1060

  Fly   960 LITELYKEGTSKDMRKWAYEIHSTFLVPRAPLSWYR--QDESLAREVDNVLQLEYDKVEILRTVF 1022
            ::.|.:|.             |.|    |:| .|.:  :|:.| ::...:..:|.|......|:.
  Fly  1061 VVRERFKP-------------HRT----RSP-DWSKRIRDKRL-QQKKAISCIEDDSDHYYETLS 1106

  Fly  1023 LRSRKRAKDLISEQLREFQQ-KRTAGLGTIYGPTDDKLAEAKTDKLREQII--DKYLMPNLHALI 1084
            ....||..   ::.:|:.|. .|:.|:.:.:..:.:..|.|.|  |.|.::  |.|   :.....
  Fly  1107 PLGNKRHS---TQLVRQSQDGNRSGGVRSSHRRSKNHSASAHT--LGEHVVISDDY---DSFETD 1163

  Fly  1085 EDENGSPPEDVRKVALCSALSTVIYRIFN-----------TRPPPSSIVERVHHFVSRDKSFKSR 1138
            .|::|....|:|:            |.:|           .:|||..  .:|:.||.:.|.|.| 
  Fly  1164 SDDHGDGEPDLRQ------------RNYNDSGVDMRNHRLPKPPPPQ--NQVYEFVRKFKDFIS- 1213

  Fly  1139 IMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIWGVSPQG-----YHCTDCKLNIHRQCSKVVDE 1198
                ::|                             ||:|     |..|......:.:|||..::
  Fly  1214 ----SKK-----------------------------SPKGSQQKLYENTPASTLFYVECSKRTED 1245

  Fly  1199 SCPG--------PLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQAS 1255
            ....        |.|:.|...|.::......|.:.      |...|||..:.|       .|.:.
  Fly  1246 VYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKN------GKSLRSRLRKSL-------VGSSF 1297

  Fly  1256 IVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVAS 1320
            ..:|.|...|     .||..........|....|:...|||             ..:|...|..:
  Fly  1298 DTKQLSSLAP-----TRSTFYVEDPEGSLPALPLEPEIHGS-------------GELDSGFSDKN 1344

  Fly  1321 TTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQH-----------PKHKSAPVSVNRSESYK 1374
            .||            ..|.....||.::|::|..:..           |.....|::.|:|.   
  Fly  1345 CTP------------LPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSP--- 1394

  Fly  1375 ERLSNKRNRNSRRKTS--------------------DPSLSSRPNDEQLDLGLSNATYVGS---- 1415
              |..:|..::.:.||                    |..::..|:..    |..::.|..|    
  Fly  1395 --LDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGH----GGVSSWYAESGLYQ 1453

  Fly  1416 -SNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHA--QQY--CQQDSF 1475
             |..|::|:.||...||..|       ||      :|...:..||.|.....  |.|  .:.:|.
  Fly  1454 TSGISVASSSGSSGVSTGNE-------AG------LGDELSSEPHSLFSNEPLYQMYSAAKLESI 1505

  Fly  1476 QAGLAGAAGSSAASNSSFWNAGHPLPVAR---WTLE-SEDEDDVNEADWS---SMVAAEVLAALT 1533
            ...|.....|.............|.|:.:   ..|: .|.::..:...||   .::.:.:|..||
  Fly  1506 TRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLT 1570

  Fly  1534 DAEKKRQEIINEIYQTERNHVRTLKLLDRLF-----------------------FLPLYESG--L 1573
            ..|:..||...||..:|.:::::|.||.|.|                       .:|::|..  |
  Fly  1571 SRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERL 1635

  Fly  1574 LS------QDHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLC 1632
            |:      ||:::||             ...:.:.:....|.||.                |..|
  Fly  1636 LTELEACWQDNIMLL-------------GLSRCIYEIAERHFHVY----------------VAFC 1671

  Fly  1633 EFAAQFCARQQIALEALKEKRNKDEM-LQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFE 1696
            |..    .|....|..|||  :|:.: .|:.|::.|:..:|..|.|...|...:||:|:.|||.:
  Fly  1672 EHQ----GRMDRTLRRLKE--SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLID 1730

  Fly  1697 NLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY------ 1755
            .::.   :..|.|..|.|:.:..:...::::.:.|:|....|.|.:|:.|.|:|:..|:      
  Fly  1731 AVFS---KESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAI 1792

  Fly  1756 ---------DKEEF--KKLDLTQHHLI---HDGNLTI-KKNPSVQLHGLLFENMIVLLTKQDDK- 1804
                     .|..|  |:.:||  ||:   .|..||. |:...:.::..||.::::|..::.:. 
  Fly  1793 APVGVPRAGAKPRFLVKRGELT--HLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESC 1855

  Fly  1805 -----YYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKM-----KTSQMLELRAP 1859
                 |..:::.|..:..:.|..|...:       ::.|.||...:..:     ||.::: |..|
  Fly  1856 FSVFDYCPRSMLTLAAGDSLPQLPTKDL-------KDQAGKNLILMTLLENCDRKTVELV-LSCP 1912

  Fly  1860 SSSECKTWFK 1869
            |.|:.:.|.:
  Fly  1913 SVSDQQRWLQ 1922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 19/98 (19%)
RGS_GEF_like 934..1055 CDD:188710 20/123 (16%)
C1_1 1151..1202 CDD:278556 8/55 (15%)
RhoGEF 1539..1731 CDD:238091 47/223 (21%)
PH_RhoGEF 1770..1875 CDD:275411 22/115 (19%)
DUF2413 2242..>2378 CDD:287302
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 45/219 (21%)
PH_ephexin 1805..1931 CDD:269929 27/128 (21%)
SH3_ephexin1_like 1944..1998 CDD:212727
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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