DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and si:dkey-172h23.2

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_957093.1	Gene:	si:dkey-172h23.2 / 393772	ZFINID:	ZDB-GENE-141212-258	Length:	221	Species:	Danio rerio

Alignment Length:	105	Identity:	23/105 - (21%)
Similarity:	42/105 - (40%)	Gaps:	32/105 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1082 ALIEDENGSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIV---------ERVHHFVSR------ 1131
            ||:.||:..|.::..|:.|  :||..:..:  |.||..|::         |.:.||.:|
Zfish   119 ALLLDEHQIPLQECEKLDL--SLSLALKHL--TLPPGWSLIGNNTRMDPQETLLHFAARRGLSKV 179

  Fly  1132 ------DKSFKSRIMGKNRKMNV-------RGHPLVLRQY 1158
                  ....:..:..:||:.:.       |||..:|..:
Zfish   180 ARFLLKQPGAREALSLRNRQGDTPVLIAQSRGHTALLELF 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	2/8 (25%)
		RhoGEF	1539..1731	CDD:238091
		PH_RhoGEF	1770..1875	CDD:275411
		DUF2413	2242..>2378	CDD:287302
si:dkey-172h23.2	NP_957093.1	ANK repeat	163..197	CDD:293786	4/33 (12%)
		ANK	<165..218	CDD:238125	10/52 (19%)
		Ank_4	166..219	CDD:290365	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910