DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and itsn1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_005171028.1 Gene:itsn1 / 368504 ZFINID:ZDB-GENE-030616-226 Length:1751 Species:Danio rerio


Alignment Length:1771 Identity:331/1771 - (18%)
Similarity:576/1771 - (32%) Gaps:611/1771 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   521 SPFGLTTD---FLQQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETG---------- 572
            :|||..:|   ....:|..|..:.       |:.|||...|....|.::.|.::|          
Zfish     6 TPFGGGSDTWVISVDERAKHDQQF-------HSLTPTPAGFITGDQARNFFLQSGLPAPILAQIW 63

  Fly   573 ----PTSKGK---NKFLISRSLIEEDVP-PPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLD 629
                ..:.||   ::|.|:..||:..:. .|||...||                           
Zfish    64 ALADMNNDGKMDMHEFSIAMKLIKLKLQGHPLPPSLPP--------------------------- 101

  Fly   630 RATSPQLNRSQQQQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQMESASAAGAAGGSIE 694
                     |.:||..|....:|              ...|.|              ||..|...
Zfish   102 ---------SMKQQPISIPPPTP--------------FGIPSM--------------GAMPGLPA 129

  Fly   695 VDGGP-PPLPPRLPGM------------MTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQND 746
            |...| |||||.:|||            ....::.|: ..:.||.|   .|::|     .||.|.
Zfish   130 VPPMPLPPLPPGVPGMGVSPPLGASVTPPVPSLANGA-PAMIQPLS---GFSHP-----GAVLNK 185

  Fly   747 NLNIAFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRH-- 809
            .     |...|.:|..|..|..:......:...|..|:.|:..|   |:|::.:|.|.|...:  
Zfish   186 T-----PSFNRSSIKLQKGQSVEAPSAPAAPPPADWAVSQSSRL---KYRQLFNSHDKMMSGYLT 242

  Fly   810 -PDRITKTTSGS---------WEI--VEKDGESS--------------------PPGTPP---PP 839
             |...|.....|         |.:  :::||:.:                    ||..||   ||
Zfish   243 GPQARTILMQSSLPQAQLATIWNLSDIDQDGKLTAEEFILAMHLIDMAMSGLPLPPLLPPDLIPP 307

  Fly   840 -----------YLSSSHMTVL---EDPNENNRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSS 890
                       .::|.|.|.|   |:|.|..:.|....|..|.:..:.....|       :|...
Zfish   308 TFRRMRSGSGVSVTSMHSTDLRSQEEPEEEEKEAEKKLPVTFEDKKRENFERG-------NLELE 365

  Fly   891 HMHAA---QSNDTQKEIISMEDE----------------NSDLD--------------------- 915
            ....|   |....|:.:.::|.|                ..:||                     
Zfish   366 KRRQALLEQQRKEQERLAALEKEEQERKERERLEQERRRQQELDKQLERQRELERQREEERRKEI 430

  Fly   916 ------------------------EPFIDENGPFNNLTRLLEAENVTF----------------- 939
                                    |.....|....|:. ||:|...|.                 
Zfish   431 ERREAAKRELERQRQLEWERTRRQELLTQRNREQENIV-LLKARKKTLEFELEALNDKKSQLEGK 494

  Fly   940 -------LAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHSTFLVP-----RAPLS 992
                   |:|..:.:.:.:....|....||.|.::  .::.::|.     :.|:|     ...|.
Zfish   495 LQDIRSRLSIQRHEIETTNKTRELRIAEITSLQQQ--LQESQQWL-----SRLIPDKQCLNDQLK 552

  Fly   993 WYRQDESLAREVDNVLQ----------------------------LEYD----KVEILRTVF-LR 1024
            ..:|: ||.|:..|.||                            ||.|    :::.||.:. .:
Zfish   553 QVQQN-SLHRDSLNSLQRAIEMKESTKQQLKEQLDAVEKETRSKLLEIDAFNTQLKELREIHNKQ 616

  Fly  1025 SRKRAKDLISEQLR--------EFQQKRTAGLGTIYGPT--DDKLAEAKTDKLREQIIDKYLMPN 1079
            .|::.|:|.::..:        :.|..|.:|......|.  ||.|.:|.|..:.:..:.:     
Zfish   617 QRQKQKELEADITQPSHDRKSIDSQDSRLSGTDDGVSPAWRDDGLGKAPTPPVSQAWMSR----- 676

  Fly  1080 LHALIEDENGSPPEDVRKVALCSALSTVIYRIFNTRP--------PPSSIVERVHHFVSRDKSFK 1136
               :.|:||.|..|          :...:.::|...|        .|.|:.:::.  ||.....|
Zfish   677 ---VSEEENHSRAE----------IQDNLSKLFTQHPQAGKIQAQSPWSMADKIP--VSGFNQEK 726

  Fly  1137 SRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTII-----WGVSPQGYHCTDCKLNIHRQCSKVV 1196
            .::: ..|.|    :|...|.:.|:|  .|...|:     |                       |
Zfish   727 VKVV-YYRAM----YPFEARSHDEIT--IHPGDIVMVKGEW-----------------------V 761

  Fly  1197 DESCPG----------------PLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDV 1245
            |||..|                |...|:::..::............::..:|:...|........
Zfish   762 DESQTGEPGWLGGEIKGKTGWFPANYAEKIPESEVPLSLRASAASSSAPKLGSHMSSASSSTTAT 826

  Fly  1246 ELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTT------------DLQSSFHGSCA 1298
            .:.|...:.:.:..||...|... ...|:.:.|.|.:..:||            |...::.....
Zfish   827 PILPVSTEPASIAPPSSAPPPTG-PASSSSSASSNWADFSTTWPSNSAVEKQDSDGWDAWPTQPT 890

  Fly  1299 NDSIN-PGGGAGCNMDLST--SVASTTPST---SGSVAAGLSAFA------------ELNALDTV 1345
            ..|:: |.||........|  :::.::||.   .|....||.|.|            ..|..|.:
Zfish   891 QPSLSVPSGGQIRQRSAFTPATLSGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVI 955

  Fly  1346 ------------DKEARRERYSQH-------PKHKS---------APVSVNR-SESYKERLSNKR 1381
                        :.:.:|..:.:.       |..||         :|.||.| |.|..:......
Zfish   956 TVLEQQDMWWFGEVQGQRGWFPKSYVKLISGPVRKSMSIESGSSDSPPSVKRPSPSLNKPTELGE 1020

  Fly  1382 NRNSRRKTSDPS-----LSSRPNDEQLDL--------------------------GLSNATYVGS 1415
            .:||...:..||     :.:..::||.||                          |:..:.||..
Zfish  1021 GQNSNSNSMYPSKEYVAMYTYESNEQGDLTFQQGDVITVTKKEGDWWTGTVSGKIGVFPSNYVKP 1085

  Fly  1416 SNS-SLSSAG--GSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQA 1477
            ..| .|.|||  ||......:....||..|.|.:...:...|    .:||::.......:...||
Zfish  1086 KESEGLGSAGKTGSLGKKPEIAQVIAPYTATGAEQLTLAPGQ----LILIRKKNPGGWWEGELQA 1146

  Fly  1478 -GLAGAAG----------SSAASNSSFWNAGHP-LPVAR----------WTLESEDE------DD 1514
             |.....|          |.:.|.::..:...| ||...          :|.:::||      ..
Zfish  1147 RGKKRQIGWFPANYVKLLSPSTSKTTPTDPNPPKLPTPNAVCQVIGMYDYTAQNDDELPFGKGQI 1211

  Fly  1515 VN-----EADW-------------------------SSMVAAE--VLAALTDAEKKRQEIINEIY 1547
            :|     :.||                         |....|:  :|..||..|:|||..|:|:.
Zfish  1212 INVLSREDPDWWKGELNGSVGLFPSNYVKLTTDTDPSQQWCADLHLLDMLTPVERKRQGYIHELI 1276

  Fly  1548 QTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIE----- 1607
            .||.|:|..|:|:...|..||.||.||::..:.::|    ::.:|:.....:.||..|:.     
Zfish  1277 VTEENYVNDLQLVTETFQKPLLESDLLTEKEVAMIF----VNWKELTMCNIKLLKALRVRKKMSG 1337

  Fly  1608 HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKAC 1672
            ....|..|||:|..........:      :||:.|......:::|.::....:..:|:......|
Zfish  1338 ERMPVKMIGDILTAQLPHMQPYI------RFCSCQLNGATLIQQKTDEVPEFKDFVKRLAMDPRC 1396

  Fly  1673 RRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTA 1737
            :.:.|...|...:||:|:|||:.:|:.:.|    ||:..:...::.|:|.::.:..:||:.|:..
Zfish  1397 KGMPLSSFLLKPMQRVTRYPLIIKNILENT----PESHPDHSHLRLALEKAEELCSQVNEGVREK 1457

  Fly  1738 EDAHKLQNIQRKLDRSSYDKE-EFKKLD--LTQHHLIHDGNLTIKKNPSVQLHGLLFENMIVLL- 1798
            |::.:|:.||..:......:: .|..:.  |.....:|.|.| .|...:.:|:|.||.:.::|. 
Zfish  1458 ENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKL-YKAKSNKELYGFLFNDFLLLTQ 1521

  Fly  1799 ------TKQDDKYYLKNLH-------TPLSIT------------NKPVSPIMSIDADTLIRQEAA 1838
                  :...||.:....|       ||:.:.            ::|:..|..||....||.|:.
Zfish  1522 IIKPLGSSGTDKVFSAKSHLQYRMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTIRAESI 1586

  Fly  1839 DKNSFFLIKMKTSQML 1854
            ::.:.::.|:|.:..|
Zfish  1587 NERTAWVQKIKAASEL 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710 30/190 (16%)
C1_1 1151..1202 CDD:278556 11/55 (20%)
RhoGEF 1539..1731 CDD:238091 47/196 (24%)
PH_RhoGEF 1770..1875 CDD:275411 24/111 (22%)
DUF2413 2242..>2378 CDD:287302
itsn1XP_005171028.1 EH 15..112 CDD:197477 25/139 (18%)
EH 26..91 CDD:238009 14/71 (20%)
EH 215..293 CDD:197477 14/80 (18%)
EH 226..292 CDD:238009 10/65 (15%)
CENP-F_leu_zip 475..611 CDD:287450 22/143 (15%)
RILP-like <546..645 CDD:304877 17/99 (17%)
SH3_Intersectin1_1 731..790 CDD:212920 16/87 (18%)
INTAP 790..932 CDD:293223 21/142 (15%)
SH3_Intersectin1_2 932..983 CDD:212922 5/50 (10%)
SH3 1034..1085 CDD:302595 7/50 (14%)
SH3_Intersectin1_4 1102..1166 CDD:212926 11/67 (16%)
SH3_Intersectin1_5 1188..1241 CDD:212928 6/52 (12%)
RhoGEF 1272..1452 CDD:279015 46/193 (24%)
PH_ITSN 1478..1609 CDD:270084 26/126 (21%)
PH 1495..1601 CDD:278594 23/106 (22%)
C2_Intersectin 1612..1746 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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