DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and arhgef1a

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_021323680.1	Gene:	arhgef1a / 368266	ZFINID:	ZDB-GENE-030722-5	Length:	1149	Species:	Danio rerio

Alignment Length:	1245	Identity:	259/1245 - (20%)
Similarity:	452/1245 - (36%)	Gaps:	292/1245 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1233 NEKRSRQDEELDVELTPDRGQASIVRQ---PSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFH 1294
            |:.||...|:||    ||  :.|:|..   .|.|..:...|:.....||.....:.|.  ....|
Zfish    77 NDTRSVSLEDLD----PD--EMSLVLNGALRSKRAREVRRSVTQASLTSLTEEEVGTE--HQDHH 133

  Fly  1295 GSCANDSINPGGGAG------CNMDLSTSVASTTPST-----------SGSVAAGLSAFAELNAL 1342
            .|...:..|...|..      |.|......::..|.:           .||..:..|.:|.| .|
Zfish   134 RSALEEQSNQMHGCSASAPSLCMMQQMPRSSAPRPRSYCHESNLHHQIGGSSNSIDSEYAAL-GL 197

  Fly  1343 DTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLG- 1406
            ||..::.:.:|  |..|...:...:.|:.|:..:::..|....:.:..:....:|..:.:...|
Zfish   198 DTDRRQVKAKR--QENKEDLSGNRLERTLSFLRKMTANRKNKEKERMREREREAREREARYSNGH 260

  Fly  1407 ------LSNATYVGSSNSSLSSAGGSESPSTSME-----HFAAPGAAGGVQ-VPPMGLNQN---- 1455
                  :|..|...:.|.|:::......|:.::.     ....|......| ...|.|.:|
Zfish   261 LFNCLTVSGTTLCSACNKSITAKEALSCPTCNVTIHNRCRDTLPNCVKMKQKQQKMALMRNNSAY 325

  Fly  1456 QHPHLLIQQHAQQ-----YCQQDSFQAGLAGA--------AGSSAASN--SSFWNAGHPLPVARW 1505
            |:..|..:.|.::     ....||.:..|.|:        ...|.::|  :...|...||.:.|.
Zfish   326 QNVTLRNKAHLKERPSSAIYPSDSLRQSLLGSRRGRSSLLLSKSVSTNNIAGTLNDDSPLGLRRI 390

  Fly  1506 TLESEDE-------------------------DDVN------EAD-WSSMVAAEVLAALTDAEKK 1538
            ..:|.|.                         :|::      ||| ||..|.:..|........|
Zfish   391 LSQSTDSLNFRSRTMSMESLNDEGECYVSSLLEDLDCEGPEFEADSWSMAVDSSYLQTHRKDVIK 455

  Fly  1539 RQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQ 1603
            ||::|.|:.|||.:|||||:::|.:|...:.|...|....:..|| |.|..|..||..|...|..
Zfish   456 RQDVIYELIQTELHHVRTLRIMDCVFRRGMLEEVQLEPGVVHALF-PCLERLLSIHTHFLTQLLA 519

  Fly  1604 RRIE-------HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQK 1661
            ||..       :|..:..|.|:|...|.||....:.:..::||:|...|::..||...:|:.||.
Zfish   520 RRAHSLQPGSTNNFTITQISDVLIKQFSGQFADDMLKAYSEFCSRHMKAVKLYKELLARDKRLQL 584

  Fly  1662 LLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRI 1726
            .:::.......||...::.:..|.||:||||:|.:.::..|    .:|..||..:.:|:...:.:
Zfish   585 FIRRVSRGPLLRRHGFQECILLVTQRITKYPVLLQRIHDNT----KDNLEEAAGLSQALACLREL 645

  Fly  1727 LVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEE----FKKLDLTQHHLIHDGNLTIKKNPSVQLH 1787
            |..|:|.|...|..|:||.|:.::|..:..|..    |:..:|.:..|||:|.| :.|.||.:|.
Zfish   646 LCSVDQQVLELERTHRLQEIRSRVDPRAEAKLRSGALFRPAELLRRQLIHEGTL-LWKTPSSRLK 709

  Fly  1788 G---LLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMK 1849
            .   ||..:::|.|.::|.::...:|..         |.::|:.: .|:|..|..:...|||..:
Zfish   710 DVQVLLMTDILVFLQEKDQRFIFASLDK---------SAVVSLQS-LLVRDIANQERGLFLISSE 764

  Fly  1850 TS--QMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLE 1912
            :|  :|.||.|.|..:..||.:.....................|.::.....|.|...:: |.||
Zfish   765 SSPPEMYELYAASKDDRNTWLRLIQQTIGSCPSREEFPLIETEDKALLRRLKADIQQKDS-EVLE 828

  Fly  1913 LSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASESDADY- 1976
            |..:.|       ||.:.....|.....:.||.:.|.....|   .|....::..|.:.::.|.
Zfish   829 LLQERV-------TLFSDLAEVMGGYEVMLPACSRNLFRAES---PQAPRGEQLLTQAITEVDRL 883

  Fly  1977 --------VNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQSTRESVRPGSTG 2033
                    :..|.|.:|....|...|:...|   |:...||::.|           ::.:.|:
Zfish   884 TELLLGSGLEVPLPCNSNGHHNPPGSLVING---QEVLVNGSQEN-----------QAAQDGN-- 932

  Fly  2034 EERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKL 2098
                       ||...|.                                         ||.|::
Zfish   933 -----------GNQMEDK-----------------------------------------TPSEEV 945

  Fly  2099 RRLDASIRNDLLEKQKIICDIFRLPVEHYDQIVDIAM----MPEAPKDSADIALAAYDQIQTLTK 2159
            .:...::...|...|.::.        ..|.|:::.:    :.:.|..:..:...:.|....:..
Zfish   946 SQRLVNLSAQLHALQGVVI--------RQDTILELCLRESPVSQTPSGARTVRSLSRDGASDMGS 1002

  Fly  2160 M----LNEYMHVTPEQEVSAVSTAVCGHCHEKEKLRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQ 2220
            :    |.:..|...::|:..:..| .|...:.|::|
Zfish  1003 VGELALLQRQHSLLQEELVRLRGA-DGKLRDSERVR----------------------------- 1037

  Fly  2221 IPPSRLMPKLQTLDLDEVAIHEDDDGYCEIDELRLPAIPSKPHERPTTPLAPFNTE-PKTSQSVI 2284
               :.|..:|:.:..:..|:  .|.|.....:     .||...|..|.|    ||: |..||..:
Zfish  1038 ---AHLEKQLRDMKTNSAAL--GDRGGTAGSQ-----APSNRRESDTDP----NTDTPLASQESM 1088

  Fly  2285 DASKRQSTDAVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADP 2349
            |.|         :||.|...:|.|......:|:||.:..|.: |||..:.:     ||.:| ::.
Zfish  1089 DQS---------DGLQECSDVEVDVISDDDDDDEVDSRVSPR-SESPRDLQ-----DIPEE-SET 1137

  Fly  2350 TTSKNEAAAS 2359
            .|...|..||
Zfish  1138 ATDPRERDAS 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	59/198 (30%)
		PH_RhoGEF	1770..1875	CDD:275411	31/109 (28%)
		DUF2413	2242..>2378	CDD:287302	33/119 (28%)
arhgef1a	XP_021323680.1	C1	260..305	CDD:237996	5/44 (11%)
		RhoGEF	456..650	CDD:238091	59/198 (30%)
		PH_ARHGEF2	690..807	CDD:275428	31/127 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840