DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Arhgef19

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001102162.1	Gene:	Arhgef19 / 362648	RGDID:	1304766	Length:	888	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	172/890 - (19%)
Similarity:	284/890 - (31%)	Gaps:	335/890 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1200 CPGPLPQA-------------KRLAHNDKISKFMGKIRPRTSDVIGNEK---RSRQ---DEELDV 1245
            |||..|..             :|.:|.                  |:||   |..|   :||...
  Rat   188 CPGAQPPTLVGPWSSQHMQPQRRASHG------------------GSEKSAWRKMQVYHNEEATG 234

  Fly  1246 ELTPD----------RGQASIVRQPSDRRPDANISIRSNGNTSCNTSGL--------NTTDLQSS 1292
            ...|.          :|||...::|   ||.     ..:|||   ..||        :.::|.:.
  Rat   235 GTEPPMGLLETGQAVQGQALCAQEP---RPQ-----ELSGNT---RGGLEAQERRRFSASELMTR 288

  Fly  1293 FHG------SCANDSINPGGGAG----------------CNMDLSTSVASTTPSTSGSVAAGLSA 1335
            .|.      |.|..::..|.|||                ..||   ||:...|.....|..||..
  Rat   289 LHSSLRLGRSTAPRALTSGSGAGVIREGKLPGREPRRAETRMD---SVSLPAPVDLNEVQGGLVE 350

  Fly  1336 FAELNALDTVDK---------EARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSD 1391
                ..|||.||         |.|:.|:..:        ||...| |.:..|.:..|..:|:...
  Rat   351 ----PRLDTNDKPTQDTNSATERRQSRFLLN--------SVLYQE-YSDVASARELRRQQREEEG 402

  Fly  1392 PSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQ 1456
            |.                           ..|.|:|.         .||       ||   ..|.
  Rat   403 PG---------------------------DGAEGAEE---------GPG-------PP---RANL 421

  Fly  1457 HPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWS 1521
            .|             ..||:     |..|:..|..|.|               :|..||.
  Rat   422 SP-------------SSSFR-----AQRSTRGSTFSLW---------------QDIPDVR----- 448

  Fly  1522 SMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFP-- 1584
               .:.|||.|:..:.|.||...|:..:|.:::.:|.:....|...:..|..|.......||.
  Rat   449 ---GSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSVELSECLGTQDKQWLFSKL 510

  Fly  1585 PALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFC-ARQQIALEA 1648
            |.:.|..|   .|...|:||             |.||:.    ...:|:.....| |.:::.|..
  Rat   511 PEVKSTSE---RFLHDLEQR-------------LEADVL----RFSVCDVVLHHCPAFRRVYLPY 555

  Fly  1649 LKEKRNKDEMLQKLLKKS----------ESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTV 1703
            :..:..::...|:||.::          |....|:||.|...|....||:|:..:|.||:.|
  Rat   556 VTNQAYQERTYQRLLLENPKFPGILARLEESPVCQRLPLTSFLILPFQRVTRLKMLVENILK--- 617

  Fly  1704 RLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQH 1768
            |..|.:..| :...:|..:.|.::.|.|.:|::.:...:|.::.:|:   .::.:.|..:...:
  Rat   618 RTTPGSQDE-DMATKAFSALKELVQECNASVQSMKRTEELIHLSKKI---HFEGKIFPLISQAR- 677

  Fly  1769 HLIHDGNLT------------IK-KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKP 1820
            .|:..|.|.            :| .:.:|.||  ||.:.::|..:::...:...:|..:
  Rat   678 WLVRHGELVELAPLPAAPPAKLKLSSKAVYLH--LFNDCLLLSRRKELGKFAVFVHANM------ 734

  Fly  1821 VSPIMSIDADTLIRQEAADKNSF----FLIKM----KTSQMLELRAPSSSECKTWFKHFSDVAAR 1877
                    |:..:|..:......    ||:::    :....|.|||.:.||.:.|
  Rat   735 --------AELQVRDLSLKLQGIPGHVFLLRLLHGQRARHQLLLRARTESEKQRW---------- 781

  Fly  1878 QSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAP-------- 1934
                                 ::|:..|:.:|..|::.|...........|...|.|
  Rat   782 ---------------------ISALRPSSPQEDKEITCDGEDRPQVQCVRTYKALQPDELTLEKT 825

  Fly  1935 -MLPIATVTP----------------APATNNSNVSSLTGVQLRN 1962
             :|.:.|.|.                .|..:...:|||: .:|||
  Rat   826 DILAVKTRTSDGWLEGVRLADGEKGWVPQAHVEEISSLS-ARLRN 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	1/1 (100%)
		RhoGEF	1539..1731	CDD:238091	46/204 (23%)
		PH_RhoGEF	1770..1875	CDD:275411	22/125 (18%)
		DUF2413	2242..>2378	CDD:287302
Arhgef19	NP_001102162.1	RhoGEF	468..645	CDD:279015	44/200 (22%)
		PH_ephexin	666..792	CDD:269929	25/173 (14%)
		PH	679..786	CDD:278594	23/153 (15%)
		SH3	805..859	CDD:302595	7/53 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810