DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF2 and Fgd3

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_008769765.1	Gene:	Fgd3 / 361223	RGDID:	1311725	Length:	733	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	152/760 - (20%)
Similarity:	256/760 - (33%)	Gaps:	231/760 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1391 DPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAG------------------GSESPSTSM--EH 1435
            |..|.|.|..:...|...:....|:..|| :|||                  |.||||:|:  |:
  Rat    22 DAGLRSSPLGKLQALPFGSGAPQGAQGSS-ASAGDSSLGEPSGAMKIPNRDSGIESPSSSVASEN 85

  Fly  1436 F-AAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHP 1499
            | ...|:.|......:||    ||.:.:...|    .||:.|.|.....|..
  Rat    86 FPCEEGSEGSPSPAILGL----HPEVAVDSRA----PQDNPQEGEDSGVGED------------- 129

  Fly  1500 LPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLF 1564
             |..:.| ....|:||.....|.             .:|...|..|:..||..:|:.|.|||::|
  Rat   130 -PDPKIT-PCRPEEDVGSTQCSD-------------PQKLLHIAQELLHTEEAYVKRLHLLDQVF 179

  Fly  1565 FLPLYESGLLSQDHLLLLFPPA--------LLSLREIHGAF-EQSLKQRRIEHNHVVNTIGDLLA 1620
            ...|.|:|:          ||.        :.|:...||.| ...||:|..|.......:||:|
  Rat   180 CAKLTEAGI----------PPEVTTGIFSNISSIYRFHGQFLLPGLKKRITEEWDTKPRLGDIL- 233

  Fly  1621 DMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVL 1685
                 |......:...::......|:..:.....:....:.::...:..:.|..|.|:..:...:
  Rat   234 -----QKLAPFLKMYGEYVKNFDRAMGLVSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPV 293

  Fly  1686 QRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKL 1750
            ||:.:|.||.::..|    .||.:..:.:..:|::|.........|.|::..|..|||..:..:|
  Rat   294 QRVPRYELLLKDYLK----RLPRDAPDRKDAERSLELISIAADHSNAAIRKMEKMHKLLEVYEQL 354

  Fly  1751 DRSSYDKEEFKKLDLTQ--HHLIHDGN---LTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNL 1810
                 ..||    |:..  :.||.:||   |:.|...:...|..||.|:::....:     |:.:
  Rat   355 -----GGEE----DIVNPANELIKEGNIQKLSAKNGTTQDRHLFLFNNVMLYCVPK-----LRLM 405

  Fly  1811 HTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHF-SDV 1874
            ....|:..|  ..|..:....:::..||  .:|.:...|.|  |||:..:..|.|.|.:.. :.|
  Rat   406 GQKFSVREK--MDISDLQVQDVVKPNAA--RTFIITGRKRS--LELQTRTEEEKKEWIQVIQATV 464

  Fly  1875 AARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIA 1939
            ...:.|:.:..|.|...|...:|:|                              :|..|:|...
  Rat   465 EKHKQKSETFRAFSGACTQEEEPSL------------------------------SPDQPVLSAG 499

  Fly  1940 TVTPAPATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEPIQK 2004
            .|.||...::|.                                               |.|
  Rat   500 PVEPAGVADSSG-----------------------------------------------GTP--- 514

  Fly  2005 YSANGTEANDVTLRHSQSTRESVRPG--STGEERNSTYGMVGGNSKRD-----SASIVC------ 2056
                |.|:..::   |::.|:..:||  |.||..||.       :||.     ...::|
  Rat   515 ----GIESRKLS---SKTRRDKEKPGCKSCGETFNSI-------TKRRYRCKLCGEVICRKCSEF 565

  Fly  2057 ----SNNSNNTRTLLMQSPLV-------DPTAIQVSISPAHTAEP 2090
                |..|...|...::.||:       .||.::.:.....:.:|
  Rat   566 KAENSKQSRVCRECFLEEPLLPTSPSSETPTELKQNAEKPPSVDP 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	41/200 (21%)
		PH_RhoGEF	1770..1875	CDD:275411	25/108 (23%)
		DUF2413	2242..>2378	CDD:287302
Fgd3	XP_008769765.1	RhoGEF	157..336	CDD:279015	41/198 (21%)
		PH-like	367..474	CDD:302622	27/117 (23%)
		PH	367..465	CDD:278594	25/108 (23%)
		FYVE_FGD3	527..580	CDD:277279	14/59 (24%)
		PH2_FGD1-4	606..710	CDD:270056	1/5 (20%)
		PH	622..711	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810