DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Plekhg5

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_038965663.1	Gene:	Plekhg5 / 310999	RGDID:	1303132	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	1249	Identity:	256/1249 - (20%)
Similarity:	411/1249 - (32%)	Gaps:	410/1249 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1140 MGKNRKMNVRGH----------PLVL-----RQYYEVTHCN-HCQTIIWGVSPQGYHCTDCKLNI 1188
            |.|.|...|..|          ||.|     .:::..||.: |   :.:.:.|||
  Rat    63 MDKGRAAKVCHHADCQQLHHRGPLNLCEICDSKFHNTTHYDGH---VRFDLPPQG---------- 114

  Fly  1189 HRQCSKVVDESCPGPLPQAKRLAHND---------------KISKFMGKIRPRTSDVIGNE---K 1235
            ......|...|||.....|..|...|               ||||  .|.|.|.:|....|   .
  Rat   115 SVLARNVSTRSCPPRTSPAGDLEEEDEGYTNGKGDRKSAGLKISK--KKARRRHTDDPSKECFTL 177

  Fly  1236 RSRQDEELDVELTPDRGQASI--VRQPSDRRPDANIS----IRSNGNTSCNTSGLNTTDLQSSFH 1294
            :...:.:::.|:.|...:.|:  |..|...|....:.    .....||.     |:.|.....|.
  Rat   178 KFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTP-----LSLTFEAYRFG 237

  Fly  1295 GSCANDSINPGGGA----GCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRERYS 1355
            |........||...    |.....|.|:.:..||.:|:           ..|:.||.::|||
  Rat   238 GHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGT-----------PVLERVDPQSRRE--- 288

  Fly  1356 QHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSL----SSRPNDEQLDLGLSNATYVGSS 1416
                           .|.......:|.:|......|.|:    |..|:...|.:|.|    ||||
  Rat   289 ---------------SSLDILAPGRRRKNMSEFLGDTSIPGQESPAPSSCSLPVGSS----VGSS 334

  Fly  1417 NSSLS---------SAGGSESPSTSMEHFAAPGAAGGVQVPPM-GLNQNQHPHLLIQQHAQQYCQ 1471
            .||.|         |...|.||||         .|.|.:|..| .|....|.:.|.
  Rat   335 GSSESWKNRAASRFSGFFSSSPST---------GAFGREVDKMEQLESKLHAYSLF--------- 381

  Fly  1472 QDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAE 1536
                  ||..........:.|            |   .|:|||..|.|.|.:...:....|.|..
  Rat   382 ------GLPRMPRRLRFDHDS------------W---EEEEDDEEEEDNSGLRLEDSWRELIDGH 425

  Fly  1537 KK-------RQEIINEIYQTERNHVRTLKLLDRLF---FLPLYESGLLSQDHLLLLFPPALLSLR 1591
            :|       :||.:.|:..||.:::|.|:::..||   .|.|.|||||.:.....|| ..:..|.
  Rat   426 EKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLF-SNIPELA 489

  Fly  1592 EIHGAFEQSL------KQRRIEHNHVVNTIGDLLA--DMFDGQSGVVLCEFAAQFCARQQIALEA 1648
            .:|.....|:      |.||   ...:....|.|.  .||..     |.:...::|..::..:|.
  Rat   490 RLHRGLWSSVMVPVLEKARR---TRALLQPSDFLKGFKMFGS-----LFKPYIRYCMEEEGCMEY 546

  Fly  1649 LKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEA 1713
            ::.....:::.:..:..:|.|:.|:||:|.|:|....|||||||||.:::.:.|     :.....
  Rat   547 MRSLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKT-----DEPRAK 606

  Fly  1714 EAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLD--------RSSYDK--EEFKKLDLT-- 1766
            |||...:.|.:|.:..||..::..::..:|..:..::|        ....||  :||..||||
  Rat   607 EAIITMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKFLKEFLHLDLTAP 671

  Fly  1767 --------QHHLIHDGNLTIK--KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPV 1821
                    ...|:.:|:|.:|  |:..:.::..||.::: |:||...|          :...|.:
  Rat   672 MPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLL-LVTKAVKK----------AERTKVI 725

  Fly  1822 SPIMSIDADTLIRQEAADKNSFFLIKMKTSQ----MLELRAPSSSECKTWF-------------- 1868
            .|.:.:  |.::.:|..|..||.||.:....    ....:|.|.:.|::|.
  Rat   726 RPPLLV--DKIVCRELRDPGSFLLIHLNEFHSAVGAYTFQASSQALCRSWVDTLYNAQNQLQQLR 788

  Fly  1869 ------------KHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPL 1921
                        :|...:...:.:...:...|. .::.|.|.:.. ..||:.:|...::|
  Rat   789 AQLLCAQEHPGTQHLQSLEEEEDEQEEEGEESG-TSAASSPTILR-KSSNSLDSEHCASD----- 846

  Fly  1922 AATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQ 1986
            .:|.||....:.|                      |..|.:|:.|.....|.:|..:..
  Rat   847 GSTETLAMVVVEP----------------------GETLSSPEFDRGPFSSQSDEASLS------ 883

  Fly  1987 NEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQSTRESVRPGSTGEERNSTYGMVGGNSKRDS 2051
               |.|.||..|.|.:.....:|...:                      .:|.||.:...|.:|.
  Rat   884 ---NTTSSITPTSELLPLGPVDGRSCS----------------------MDSAYGTLSPTSLQDF 923

  Fly  2052 ASIVCSNNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKII 2116
            |:               ..|:|:|..:..::||        .|..:|||
  Rat   924 AA---------------PHPVVEPVPVPQTLSP--------QPSPRLRR---------------- 949

  Fly  2117 CDIFRLPVEHYDQIVDIAMMPEAP---KDSADIALAAYDQIQTL------------TKMLNEYMH 2166
                |.||:         ::|..|   |..::.:|     :|.|            ::.|:|...
  Rat   950 ----RTPVQ---------LLPRLPHLLKSKSEASL-----LQLLSGTTTSVSPPAPSRSLSELCL 996

  Fly  2167 VTPEQEVSAVST-----------AVCGHCH-------EKEKLRKKVAPSSSFSS----------- 2202
            :|....|...|:           ..||.|.       |.....|...|:.|...
  Rat   997 ITMAPGVRTQSSLQEGGPGWNCPGACGPCQGPPLSESENRPSHKAGGPADSARRKCREMPCGTVP 1061

  Fly  2203 --SPPPLPPPNRQH 2214
              .|.|.|..:.||
  Rat  1062 RVQPEPSPGISAQH 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	13/66 (20%)
		RhoGEF	1539..1731	CDD:238091	54/202 (27%)
		PH_RhoGEF	1770..1875	CDD:275411	25/136 (18%)
		DUF2413	2242..>2378	CDD:287302
Plekhg5	XP_038965663.1	RBD_PLEKHG5	172..246	CDD:340588	13/78 (17%)
		RhoGEF	438..624	CDD:214619	52/199 (26%)
		PH_PLEKHG5_G6	681..779	CDD:270064	24/110 (22%)
		Atrophin-1	913..>1077	CDD:397323	39/220 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810