DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Arhgef2

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_006232705.1	Gene:	Arhgef2 / 310635	RGDID:	1304659	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1437	Identity:	291/1437 - (20%)
Similarity:	499/1437 - (34%)	Gaps:	447/1437 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1115 RPPPSSIVERVHHFVSRDKS-------FKSRIMGKNRKMNVRGHPL-VLRQYYEVTHCNHCQTII 1171
            |.|.....||:.....:|::       |.:..:.::|....|.|.. .|:::            .
  Rat    19 RLPAVESRERLEEVEGKDENQDNNNDVFHTSFLRRSRAFRARSHTSEALKRH------------S 71

  Fly  1172 WG--------VSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTS 1228
            ||        :|.:..|.::|.          |.:..|                 |:     ::.
  Rat    72 WGPGKEFQDPISRRSLHSSECP----------VSQEAP-----------------FL-----QSL 104

  Fly  1229 DVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSF 1293
            :.:|....::|.|:       .:|:.....||..|           |.:.|:.|
  Rat   105 EELGTPLGAQQQEQ-------QQGREQQSGQPFHR-----------GQSFCHLS----------- 140

  Fly  1294 HGSCANDSINPGGG--------AGCNMDLSTSVASTTPSTS---------------GSVAAGLS- 1334
                |..|::|..|        :|.|:.|..|..:...|.|               ....||.|
  Rat   141 ----ATSSVHPATGMLSKAVSMSGINLLLDCSDPNGNSSQSHATDLNKCGKQLEEDSGTWAGSSL 201

  Fly  1335 --AFAELNALDTVD--------KEARRERYSQHPKHKSAPVSV---------NRSESYKERLSNK 1380
              .|:.|..:...|        |||:..||:.  .|....:||         |:|.:.||.|.
  Rat   202 RRTFSFLLGMTGRDKTREKEKMKEAKDARYTN--GHLFTTISVSGMTMCYACNKSITAKEALI-- 262

  Fly  1381 RNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGS---------SNSSLSSAGGSESPSTSMEHF 1436
                  ..|.:.::.:|..|.     |:|.|.|..         :|::|.|. ...|.:|:.|.
  Rat   263 ------CPTCNVTIHNRCKDT-----LANCTKVKQKQQKAALLRNNTALQSV-SLRSKTTTRER- 314

  Fly  1437 AAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGA----AGSSAASNSSFWN-A 1496
              |.:|    :.|                      .|||:..|.|:    :..|.|.:.|..| |
  Rat   315 --PTSA----IYP----------------------SDSFRQSLLGSRRGLSSLSLAKSVSTTNIA 351

  Fly  1497 GH------------------PLPVARWTLESE--------------------DEDDVNEADWSSM 1523
            ||                  .|.:...||..|                    ||.|.....||..
  Rat   352 GHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLA 416

  Fly  1524 VAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALL 1588
            |.:..|........|:|::|.|:.|||.:||||||::.|||...:.|...:..:.:..|| |.:.
  Rat   417 VDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLF-PCVD 480

  Fly  1589 SLREIHGAFEQSLKQRRIE-------HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIAL 1646
            .|.:||..|...|.:||.:       .|.|::.:||||...|.|.:...:.:..::||:|...||
  Rat   481 ELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKAL 545

  Fly  1647 EALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPEN-- 1709
            :..||...:|:..|:.::|.......:|..:::.:..|.||:||||:|..       |:|..:
  Rat   546 KLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLIN-------RILQNSHG 603

  Fly  1710 -TTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY----DKEEFKKLDLTQHH 1769
             ..|.:.:..|:...|.:|..|:|.|...|...:||.|..::|..:.    .|..|.:.:|.:..
  Rat   604 IEEEYQDLAAALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDELLRRK 668

  Fly  1770 LIHDGNLTIK----KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDAD 1830
            |||||.|..|    :...|.|  ||..:::|.|.::|.||...:|..|         .::|:. :
  Rat   669 LIHDGCLLWKTATGRFKDVLL--LLMTDVLVFLQEKDQKYIFTSLDKP---------SVVSLQ-N 721

  Fly  1831 TLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHF----------SDVAARQSKNRSKN 1885
            .::|..|......|||.....:|.|:.|.|..:..||.:..          .|....::::::..
  Rat   722 LIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYL 786

  Fly  1886 ASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNS 1950
            ..........:.||..:...|    :||..:.|...|..|.....| .|.||....      ...
  Rat   787 RRIKTKLQQKNQALVELLQMN----VELFAEMVHFQALKAGFIGMP-PPTLPRGLF------RLE 840

  Fly  1951 NVSSLTGVQLRNPQRDATAS-ESDADYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSAN--GTEA 2012
            :..||.|.:|   .:||... |...|.:..|.       |:..::.|....|::..|.:  |..|
  Rat   841 SFESLRGERL---LKDALREVEGLKDLLLGPC-------VDLPLTAREPALPVEADSGSCPGVTA 895

  Fly  2013 NDVTLRHSQSTRESVRPGSTGEER--NSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVDP 2075
            |                   ||.|  |.:..:    .:.||.|.....|.|..|
  Rat   896 N-------------------GEARTFNGSIEL----CRADSDSSQKDRNGNQLR----------- 926

  Fly  2076 TAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKIICDIFRLPVEHYDQIVDIAMMPEAP 2140
                   ||   .|..|.|...|..|...::..::::::::                .|:.||.|
  Rat   927 -------SP---QEEALQPLVNLYGLLQGLQAVVVQQERLM----------------EALFPEGP 965

  Fly  2141 K-------------DSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHCHEKEKLRK 2192
            :             ::...|:|:                ||||::.:.::.....|...:|:||:
  Rat   966 ERWEKLSRANSRDGEAGRAAVAS----------------VTPEKQATELALLQRQHSLLQEELRR 1014

  Fly  2193 KVAPSSSFSSSPPPLPPPNRQHAQAQAQI--PPSRLMPKLQTLDLDEVAIHEDDDGYCEIDELR- 2254
            ........::....|....|:..||:|.:  ....:..:|..|..:|....|.......:|..|
  Rat  1015 CQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRR 1079

  Fly  2255 -LPA-----------IPSKPHERPTTPLAPFNTEPKTSQSVIDASKRQSTDAVPEGLLEQEPLEG 2307
             |||           .||:.|:|...|:        |.:|:                  ..|.:.
  Rat  1080 SLPAGDALYLSFNPPQPSRGHDRLDLPV--------TVRSL------------------HRPFDD 1118

  Fly  2308 DKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKNEAAASVDELPSQSREIKT 2372
            .:.:..|.       |.|:|.:|.:.: .|.|.:::..::.|.:.::  ...:.::|.::.....
  Rat  1119 REAQELGS-------PEDRLQDSSDPD-TCSEEEVSSRLSPPHSPRD--FTRMQDIPEETESRDG 1173

  Fly  2373 AENASKS 2379
            ...||:|
  Rat  1174 EPTASES 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	8/59 (14%)
		RhoGEF	1539..1731	CDD:238091	59/201 (29%)
		PH_RhoGEF	1770..1875	CDD:275411	31/118 (26%)
		DUF2413	2242..>2378	CDD:287302	24/148 (16%)
Arhgef2	XP_006232705.1	C1_ARHGEF2	230..290	CDD:410427	17/74 (23%)
		RhoGEF	432..626	CDD:238091	59/201 (29%)
		PH_ARHGEF2	666..781	CDD:275428	31/126 (25%)
		SMC_prok_B	<898..>1057	CDD:274008	36/215 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740