DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and Arhgef26

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_227201.4 Gene:Arhgef26 / 310460 RGDID:1562559 Length:869 Species:Rattus norvegicus


Alignment Length:857 Identity:161/857 - (18%)
Similarity:298/857 - (34%) Gaps:258/857 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1175 SPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQ 1239
            ||.|...||..:   .:.:.:.....|.|:|....           |:...|:..::...:|...
  Rat    41 SPSGLLITDFPV---EELAALPAPQTPVPVPAGPE-----------GRTVSRSPQLLCAHRRPVT 91

  Fly  1240 DEELDVELTPDRGQASIVRQPSDRRPDAN-ISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSIN 1303
            :..   .::||...||    |..|||.:. :|..::|.:.           :|:.:|:.::.:  
  Rat    92 NGR---TVSPDYRAAS----PRLRRPKSPLVSYAASGGSP-----------KSAVNGTVSSPA-- 136

  Fly  1304 PGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQHPK-HKSAPV-- 1365
                      ...|.||.||....|.|.|     |.....|..|.:........|| ..|.||  
  Rat   137 ----------ALLSRASRTPDIPASSAPG-----EDRTRVTASKVSSPTANGLAPKTDSSGPVSQ 186

  Fly  1366 ---SVNRSESYKERLS-NKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGS 1426
               |....|....||| ..::|:|.:|.....|.|:.|:      |.|.:.:.|:||..:...|.
  Rat   187 TGQSAGDLEPSPSRLSPAPQHRSSEQKLPLQRLPSQGNE------LPNPSVILSTNSPAALKMGK 245

  Fly  1427 ESPSTSMEHFAAPGAAGGVQVPPMGL----------NQNQHPHLLIQQHAQQYCQQDSFQAGLAG 1481
            :                  |:.|..|          :||..||       ::..:..|...||..
  Rat   246 Q------------------QIIPKSLASEIKLSKSNSQNVEPH-------RRLLKVRSMVEGLGA 285

  Fly  1482 AAG----SSAASNS---------------------SFWNAGHPL----------PVARWTLE--- 1508
            ..|    .|.|.|.                     |.::...|.          ||.:..:|   
  Rat   286 PLGPEGEESEADNDIDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKAVMEDKE 350

  Fly  1509 ---------------------------------------SEDEDDVNE---------------AD 1519
                                                   |::|.:..|               :.
  Rat   351 KFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEEPEPKEQKPEEKIVIHHKPLRST 415

  Fly  1520 WSSMVAAE---VLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLF--FLPLYESGLLSQDHL 1579
            ||.:.|.:   :...::..|:||||.|.|:..:|.:::.:|::|.|:|  ...|.::...::.|.
  Rat   416 WSQLSAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKDSKELTDTMTKTERHH 480

  Fly  1580 LLLFPPALLSLREIHGAFEQSLK-----QRRIEHNHVVNTIGDLL----ADMFDGQSGVVLCEFA 1635
            |         ...|...:|.|.|     :.|.::|..:..|.|::    |..||..         
  Rat   481 L---------FSNITDVWEASKKFFTELEARHQNNIFIEDISDIVEKHTASTFDPY--------- 527

  Fly  1636 AQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYK 1700
            .::|..:......|::....:...:::|.:.|||:.||.|.:...|...:||:|:.|||.:.:.:
  Rat   528 VKYCTNEVYQQRTLQKLLTTNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQ 592

  Fly  1701 VTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFK---- 1761
            .|    |:::.:.|..:||::...:::...|:..:..|....:..|..:|        |||    
  Rat   593 KT----PKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQL--------EFKIKPF 645

  Fly  1762 KLDLTQHHLIHDGNLTI---------KKNPSVQLHGLLFENMIVLLTKQDDKYYLKN---LHTPL 1814
            .|..:...|:..|.||.         |:....|::..||.:::::..|:.::.|..|   |...|
  Rat   646 PLVSSSRWLVKRGELTAYVEDTVLFSKRMSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQL 710

  Fly  1815 ---SITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLE-----LRAPSSSECKTWFKHF 1871
               |..|:.::.....:..|::....:.....|.:.:.::...|     |.|.:.||...|....
  Rat   711 LVESCDNEELNSSPGKNTSTMLYSRQSSATHLFTLTVLSNHANEKVDMLLGAETQSERARWITAL 775

  Fly  1872 SDVAARQSKNRS 1883
            ...:.:|..:|:
  Rat   776 GHSSGKQPPDRT 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556 5/26 (19%)
RhoGEF 1539..1731 CDD:238091 45/202 (22%)
PH_RhoGEF 1770..1875 CDD:275411 23/124 (19%)
DUF2413 2242..>2378 CDD:287302
Arhgef26XP_227201.4 TDA11 140..>348 CDD:293689 51/243 (21%)
RhoGEF 441..620 CDD:279015 42/200 (21%)
PH_ephexin 641..779 CDD:269929 25/137 (18%)
SH3_ARHGEF16_26 791..845 CDD:212871
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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