DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and Akap13

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_038961459.1 Gene:Akap13 / 293024 RGDID:727893 Length:2793 Species:Rattus norvegicus


Alignment Length:2735 Identity:525/2735 - (19%)
Similarity:897/2735 - (32%) Gaps:886/2735 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 IPEESSIQPPETSTSHTSTNGS-----SHSGPGTATGPGATSAGPSAGAPQSPVIVVD------S 79
            :|:::|    |:|..|..:..|     |.:|.||   |.|.||.|.:....|...|::      |
  Rat   618 MPKQNS----ESSAQHAQSLNSQAPLCSIAGAGT---PSAESACPQSTETSSGGSVIEHGSGEAS 675

  Fly    80 VPELPAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLASSLSSLA-----SSLSGH------RDRD 133
            :||           |.:.|.:.|....:..|..|...:..|..|     |..|.|      ::::
  Rat   676 LPE-----------STAAQPEPQGLCTAPCPEDPQADTVTSDTAAHNQKSVGSCHLCALDAKNQE 729

  Fly   134 KDRDKDRENQNAVP--PQTPPLPPSYKQNQMNGDSTAAAGGGVSAPATPTTANNNNASHNNGSIM 196
            ||..:|..:.|.:.  |..|.:.|. .:.::..|..:..|...|..::|     .:.|.....::
  Rat   730 KDLRQDTPSVNTLEDVPHLPSVVPQ-SEEKLEPDQVSPRGSSFSLASSP-----ESESVTKDDVL 788

  Fly   197 GGGVQLNQSDNSNPVL-QAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLALPKNFQYLT 260
            .......:...:.|.| :||    :.:..|..|||:  .|.:....|.:|.|||           
  Rat   789 SLVSSQKEKGTATPQLHRAP----ACSDGPDGRDLN--DTDKVGDGAASPPTPS----------- 836

  Fly   261 LTVRKDSNGYGMKVSGDNPVFVESVKPGGAAEIAGL-------VAGDMILRVNGHEVRLEKHPTV 318
                    ...::.|..|      ..|.|..|..|.       |..|.:|:              
  Rat   837 --------AVELQTSMGN------TSPVGVGEQEGSSLTATLEVLSDSLLQ-------------- 873

  Fly   319 VGLIKASTTVELAVKRSQKLTRPSSVSVVTP--STPI-LSGRDRTASITGPQPVDSIKRREMETY 380
                    :|:.|...|..|......|:|.|  ||.: ..|:|:....  |...:.:...||.  
  Rat   874 --------SVDKAALVSDSLLPEEGGSIVVPESSTALGQGGKDKATKC--PSVKEDVHSSEMS-- 926

  Fly   381 KIQTLQKMLEQEKLNLERLKSDQNNPS-----YKLSEANIRKL---REQLHQVGAEDAPTVKLQA 437
                               :.||..|.     .:|.|..:..|   .:.|....:.|.|:..||.
  Rat   927 -------------------REDQRTPPPGQEISRLCEKPMSALCAGEKALQHSNSPDTPSACLQT 972

  Fly   438 -AAGNKNTA-----LLTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSL 496
             ...||..|     |:....:|:|....|..:..                .:|:.:||..:..||
  Rat   973 ETKHNKEVAPQSSPLMKGGAVQNLVPPKTSLSAD----------------SEQKTSSTEQSGSSL 1021

  Fly   497 LPRSLS--------SLSLGTR----KNKTE---------KDLTTSSPFGLTTDFLQQQRMSHQAE 540
            ||...|        |||:...    :.||.         :|:|.:..|..|.:..::..: |..:
  Rat  1022 LPGGASEALRCSQPSLSVSVESIQFQGKTSACKVSRNAMEDVTVADAFLATAEPTKEDAL-HHVK 1085

  Fly   541 SMSQSMHQHTSTPTS-------------QQFFHPHQQQ---HRFKETG-----PTSKGK---NKF 581
            .:|..::|...|...             |:...|..:.   .|.|..|     ||||.|   |. 
  Rat  1086 DISDLLNQEKKTTPGLPEALLDKGVTDLQEVITPEIEPLDCKREKLEGTDLSCPTSKSKETPNN- 1149

  Fly   582 LISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQQQLPS 646
                   ||...|  |.|:.|.:..|...|.|         .|.:|:...|.            :
  Rat  1150 -------EETTQP--PARDLPTETGLSAINDN---------GPQADMKHVTQ------------A 1184

  Fly   647 STDNSPSNAKSKRSKIKTKALSDP-------KMSTQMF-LQMESASAAGAAGGSIEVDGGPPPLP 703
            |.....||..:....:.|:|...|       :.:|::. ..::...|:......:|:..  |||.
  Rat  1185 SVPGEESNVTTVLGMVSTQAADGPPGADSIEETATRIVEAVIKQIKASNTLRTQVEIQN--PPLS 1247

  Fly   704 PR----------------LPG-----MMTEDMSRGSCQ-NLAQPNSVGTAFNYP-----LVSTTT 741
            ..                |||     ..|:..:.|.|. ....|..:..|.:.|     :..|.|
  Rat  1248 SSEIKEIENTGSESARVFLPGEPLQMENTQKETTGHCSVETEAPEKIILAVHRPEPAPEMPDTKT 1312

  Fly   742 AVQNDNLNIAFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMH 806
            ..:.|.|:               ::....::..:..|.||..:.|.|          |:...|..
  Rat  1313 GGEVDLLS---------------KRSAASEEEAIGNGAATPKMKQAP----------GTQVINRE 1352

  Fly   807 PRHPDRITKTTSGSWEIVEKDGE-----SSPPGTPPPPYL------------------SSSHMTV 848
                         ||..:|...|     :|...:....::                  |.|...:
  Rat  1353 -------------SWCAIEPCPEAASLLASKQSSECRSFIDVGLGTECATKEGVLQRESGSDSDL 1404

  Fly   849 LEDPNENNRGAAAAGPGVFIESHQFTPMAGASS----PIPISLHSSHMHAAQSNDTQKEIISMED 909
            ...|::.......:.|.   |........|:||    ...:..||||........|.|...|...
  Rat  1405 FHSPSDEMDSIIFSKPE---EEQLLCDTTGSSSSTDDTASLDRHSSHGSDVSLPQTSKLNRSRNH 1466

  Fly   910 ENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMR 974
            ::|         ||.|::                      ..||..          :||.|:   
  Rat  1467 QSS---------NGFFSH----------------------GVDPES----------REGESE--- 1487

  Fly   975 KWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKDLISEQLRE 1039
                           |......:|   .|:|::.::..::      .|||:..|:       |..
  Rat  1488 ---------------PAGSGEMEE---EEMDSITEVPANR------SFLRNSMRS-------LSP 1521

  Fly  1040 FQQKRTAGLGTIYGPTDDKLAEAKTDKLREQIIDKYLM--PNLH---------------ALIEDE 1087
            |::..       :||..:..::|:.::.....:..:::  |.:|               ||..|.
  Rat  1522 FRRHS-------WGPGKNAASDAEMNQRSSMQVLGHVVRRPPIHRRSMSWCPSGVQYSAALNADF 1579

  Fly  1088 N---------------GSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIV----------ERVHH 1127
            |               |:.|..  .:.:.||.|:.:...|:.....||::          :|.||
  Rat  1580 NIRSFSLEGLTGGGGVGNKPSS--SLEISSANSSELRNPFSGEEQRSSLMSLSEEHLEPDQRQHH 1642

  Fly  1128 -FVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTI-IWGVSPQG------YHCTDC 1184
             ...:...::|:..|.|...:....||.             ::| :..:|..|      :|....
  Rat  1643 RMFDQQTCYRSKQQGFNYCTSAISSPLT-------------KSISLMTISHPGLDNSRPFHSASA 1694

  Fly  1185 KLNIHRQCSKVVDESC----PGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDV 1245
            .|.     ..:.:|:|    |.|..::.......|:|:....||.:.|    :.|:|::.|: :.
  Rat  1695 NLT-----ESITEENCNFLPPSPSKKSFEEKSGTKVSRTFSYIRNKMS----SSKKSKEKEK-EK 1749

  Fly  1246 ELTPDRGQASIVRQPSDRRPDANISIRSNGNT----------SCNTSGLNTTDLQSSFHGSCAND 1300
            :.|.::.:.|..:: .|::       ..||:|          :|:......|:..:....||   
  Rat  1750 DKTKEKEKESKEKE-KDKK-------TLNGHTFSPIPIVGPINCSQCMKPFTNKDAYTCASC--- 1803

  Fly  1301 SINPGGGA----GCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQHPKHK 1361
                  ||    ||..:|::..........||:.|     .:.::|.||   ..|.:.|| ||.:
  Rat  1804 ------GAFVHKGCRENLASCAKVKMKQPKGSLQA-----HDTSSLPTV---IMRNKSSQ-PKER 1853

  Fly  1362 ------------SAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLD---LGLSNAT 1411
                        :||:..||.......||        :..|..:::...|||.:.   ..||::|
  Rat  1854 PRSAVLLAEEAIAAPMFTNRRSQQSVSLS--------KSVSIQNITGVGNDENMSNTWKFLSHST 1910

  Fly  1412 -------YVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQY 1469
                   .|..|..||:..|                         :|.:.|:             
  Rat  1911 DSLNKICKVNESTESLTDEG-------------------------VGTDMNE------------- 1937

  Fly  1470 CQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTD 1534
                       |.......|:|.             .||:|        .||..|.::.|.....
  Rat  1938 -----------GQLMGDFESDSK-------------QLEAE--------SWSRTVDSKFLKQQKK 1970

  Fly  1535 AEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQ 1599
            ...||||:|.|:.|||.:|:||||::..::...:....|..|..:..|| |.|..|..||..|.|
  Rat  1971 DVVKRQEVIYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMVEKLF-PCLDELISIHSQFFQ 2034

  Fly  1600 SLKQR-------RIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDE 1657
            .:.:|       :.|.|.::..|||:|...|.|::...|.:...:||.:...::...|:...||:
  Rat  2035 RILERKKESLVDKSEKNFLIKRIGDVLVSQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYTKDK 2099

  Fly  1658 MLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVES 1722
            ..|..:||..|....|||.:.:.:..|.||:||||:||:.:.:.|    .:|..|.|.:.:::..
  Rat  2100 RFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT----KDNEVEQEDLTQSLSL 2160

  Fly  1723 SKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDK----EEFKKLDLTQHHLIHDGNLTIKKNPS 1783
            .|.::..|:..|.:.|...:|..|..|.|..|..:    :.|.|.||.:..|:.||::.:|....
  Rat  2161 VKDVIGAVDSKVASYEKKVRLGEIYTKTDSKSIMRMKSGQMFAKEDLRRKKLVRDGSVFLKSATG 2225

  Fly  1784 --VQLHGLLFENMIVLLTKQDDKYYLKNL-HTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFL 1845
              .::..:|..:::|.|.::|.||...:| |....|:.|.:          ::|:.|.::...||
  Rat  2226 RLKEVQAVLLTDILVFLQEKDQKYVFASLDHKSTVISLKKL----------IVREVAHEEKGLFL 2280

  Fly  1846 IKM--KTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTK 1908
            |.|  |..:|:|:.|.|..|..:|.:...|.....:::..:...|.::   .:..|........|
  Rat  2281 ISMGVKDPEMVEVHASSREERNSWIQIIQDTINSLNRDEDEGIPSENE---EEKRLLDTKARELK 2342

  Fly  1909 ESLE-------LSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRD 1966
            |.|:       |..:..:.:....|..:||| |.....|.:|.....::...:|.|         
  Rat  2343 EQLQQKDQQILLLLEEKEMIFRDMTECSTPL-PEDCSPTHSPRMLFRSNTEEALKG--------- 2397

  Fly  1967 ATASESDADYVNTPKPRSSQNEVNRTMSIRS------TGEPIQKYSANGTEANDVTLRHSQST-- 2023
                        .|..:|:.:||.....:.|      .|:||.........|..::|.....|  
  Rat  2398 ------------GPLMKSAISEVEILQGLVSGSLGGTLGQPISSPVEQEVMAGPISLPRRAETFG 2450

  Fly  2024 --------------RESVRPGSTGEERNSTYGM-VGGNS------KRDSASIVCS-NNSNNTRTL 2066
                          :|....|.......|..|: .|||:      ||:|..:|.| .:.:...|:
  Rat  2451 GFDCHQLNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSIVHLHELLTM 2515

  Fly  2067 LMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKIICDIFRLPVEHYDQIV 2131
            |....|...:.|:       ..:.|||  ||:....||..:.|:|::|                 
  Rat  2516 LQGVVLQQDSYIE-------DQKLVLT--EKVLTRSASRPSSLIEQEK----------------- 2554

  Fly  2132 DIAMMPEAPKDSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHCHEKEKLRKKVAP 2196
                .....|...|:|.....|.|                           |..||.:..::...
  Rat  2555 ----QRSLEKQRQDLANLQKQQAQ---------------------------HLEEKRRREREWEA 2588

  Fly  2197 SSSFSSSPPPLPPPNRQHAQAQAQIPPSRLMPKLQTLDLDEVAIHEDDDGY-CEIDELRLPAIPS 2260
            ..        |...:|:...|:.:....|   :.|.|:.|...:.:....| |:::.||      
  Rat  2589 RE--------LELRDREAKLAEREETVRR---RQQDLERDREELQQKKGTYQCDLERLR------ 2636

  Fly  2261 KPHERPTTPLAPFNTEPKTSQSVIDASKRQSTDAVPEGLLEQEPLEGDKTETKGEDNEVKTVP-- 2323
                     .|....|.:..|...||.:           |.|..:|.|..:...:...:..||  
  Rat  2637 ---------AAQKQLEREQEQLKRDAEQ-----------LSQRQMEQDLCQVSNKHGRLMRVPSF 2681

  Fly  2324 ---SDKLSESCNEERQCVEADITKEVADPTTSKNEAAASVDELPSQSREIKTAENASKSVADK-- 2383
               ||:.|                .::.|:.:|   :.|:|...|.|.:   ..:.|::..||  
  Rat  2682 LPNSDEFS----------------LLSTPSITK---SGSLDSELSVSPK---RNSISRTQKDKGP 2724

  Fly  2384 ----KEDNEETIEEGVASTVDSSTQTS--------PTESPKETDKLTGGSSSTCGPNRIQHASVL 2436
                ...::..:.|| .|...|||.||        |.|. ||..|.:.||       |.|.....
  Rat  2725 FHILSSASQTKVPEG-QSQAPSSTSTSTRLFGLSKPKEK-KEKKKKSKGS-------RTQPGDGP 2780

  Fly  2437 EPSVP 2441
            .|.||
  Rat  2781 APEVP 2785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 11/80 (14%)
RGS_GEF_like 934..1055 CDD:188710 16/120 (13%)
C1_1 1151..1202 CDD:278556 9/61 (15%)
RhoGEF 1539..1731 CDD:238091 60/198 (30%)
PH_RhoGEF 1770..1875 CDD:275411 28/109 (26%)
DUF2413 2242..>2378 CDD:287302 24/141 (17%)
Akap13XP_038961459.1 PHA03307 545..>837 CDD:223039 56/267 (21%)
C1_AKAP13 1769..1824 CDD:410428 12/63 (19%)
RhoGEF 1975..2169 CDD:238091 60/198 (30%)
PH_AKAP13 2212..2314 CDD:275427 28/111 (25%)
SMC_prok_B <2509..>2669 CDD:274008 42/253 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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