DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Arhgef15

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_008766014.1	Gene:	Arhgef15 / 287418	RGDID:	1306961	Length:	850	Species:	Rattus norvegicus

Alignment Length:	1035	Identity:	202/1035 - (19%)
Similarity:	324/1035 - (31%)	Gaps:	364/1035 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1110 RIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIWGV 1174
            ||...|||..   .|..|......:..|              |..|.|.......:.|.:|.| .
  Rat    18 RIIRPRPPSR---HRAPHSPGPPHNGSS--------------PKALPQISNDASASVCTSIFW-E 64

  Fly  1175 SPQG-------YHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIG 1232
            .|.|       ...:..:.::..|.|.....|.|.|.|.::|
  Rat    65 PPTGSLKPPALLPPSVSRASLDSQTSPDSPSSTPSPSPVSRR----------------------- 106

  Fly  1233 NEKRSRQDEELDVELTPDRGQASIVRQP----SDRRP---------DANIS----IR-------- 1272
                         .::|:....|.|..|    |.|.|         |.:.|    :|
  Rat   107 -------------SISPEPAPCSPVPPPKPSGSSRTPLPLGPVPLQDGSASAPGTVRRLAGKFEW 158

  Fly  1273 ---------------SNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTT 1322
                           |.|:|..|  |...| ||....|:.:.::..|.....|        ....
  Rat   159 GAEGKAQSADSLERCSQGSTDVN--GEKET-LQVGLSGNGSQENGTPDAALAC--------PPCC 212

  Fly  1323 PSTSGSVAAGLS-AFAELNALDTVDK--------EARRERYS----QHPKHKSAPVSVNRSESYK 1374
            |........||. .:..:.:.|.:.:        .|.|.|.:    .||     ||.:....|..
  Rat   213 PCVCHVAKPGLELRWVPVGSSDDILRAPCRASPLRASRSRINPPVISHP-----PVVLTSYRSTA 272

  Fly  1375 ER-----LSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSME 1434
            ||     |...:....|:.||......:|     ||.|.:...:.::..:.......|:|..
  Rat   273 ERKLLPPLKPPKPTRVRQDTSTSGELPQP-----DLELPSEDGIQAAPKAWEGDRPEEAPQN--- 329

  Fly  1435 HFAAPGAAGGVQVPPMGLNQNQHPHL----------------LIQQHAQQYCQQDSFQAGLAGAA 1483
               ||        ||:.|...:...|                |.|.:......::.:..|..|
  Rat   330 ---AP--------PPVALEGREEEGLEGLKELQWELPLQDEPLYQTYRAAVLSEELWGVGEDG-- 381

  Fly  1484 GSSAASNSSFWNAGHP-----LPVARWTLESEDEDDVNEADWSSMVAAE---VLAALTDAEKKRQ 1540
            |.|.|      |.|..     ||..|.||            |..:.|..   :|.:|:..|::.|
  Rat   382 GPSPA------NPGEAPTFSRLPGPRNTL------------WQELPAVRGSGLLESLSPQERRMQ 428

  Fly  1541 EIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPAL---LSLREIHGAFE---- 1598
            |.:.|:..:|.:::|:|:||...|        :|||         ||   |:.|:.|..|.
  Rat   429 ESLFEVVTSEASYLRSLRLLTDTF--------VLSQ---------ALRDTLTPRDHHTLFSNVQR 476

  Fly  1599 -QSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA-AQFCARQQIALEALKEKRNKDEMLQK 1661
             ||:.:|         .:|.||:.:........||:.. |.......:.::.::.::.::|...:
  Rat   477 VQSVSER---------FLGTLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSR 532

  Fly  1662 L----------LKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAI 1716
            |          |::.:|...|.||.|...|....||:|:..:|.:|:...|    .|.::..|..
  Rat   533 LMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQT----EEGSSRQENA 593

  Fly  1717 QRAVESSKRIL----VEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLIHDGNLT 1777
            |:|:.:..:|:    .||.:..:|.|       :.|...|..:.|.:...|......|...|.||
  Rat   594 QKALGAVSKIIERCSAEVGRMKQTEE-------LIRLTQRLRFHKVKALPLVSWSRRLELQGELT 651

  Fly  1778 IKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNS 1842
               ....:..|:||.:              :...|||.:.         :.:|.|:
  Rat   652 ---ELGCRRGGVLFTS--------------RPRFTPLCLL---------LFSDLLL--------- 681

  Fly  1843 FFLIKMKTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRS------KNASSNHD---------- 1891
              :.:.|:.|.|::..         :.|.|.|.|:|..:.|      .:..|||.
  Rat   682 --ITQPKSGQRLQVLD---------YAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQA 735

  Fly  1892 TSISDPA--LAAIPHSNTKESLELSTDTV-QPLAATATLTTTPLAPM------------------ 1935
            .|:||..  |.|.|   |...|..|.||: :....:..|.:.|..|.
  Rat   736 ASLSDMQRWLGAFP---TPGPLPCSPDTIYEDCECSQELCSEPSTPSKTEGQSLESKAPRKHLHK 797

  Fly  1936 --------LPIATVTPAPATNNSNVSSLTG-----VQLRNPQRDATASESDADYVNTPKP 1982
                    ||.|  .||..     |..:||     ..||..|:...|:...:|..:||:|
  Rat   798 NPEGWLKGLPGA--FPAQL-----VCEVTGEHERRKHLRQHQKLLEAAGPSSDTPDTPQP 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	11/57 (19%)
		RhoGEF	1539..1731	CDD:238091	48/214 (22%)
		PH_RhoGEF	1770..1875	CDD:275411	17/104 (16%)
		DUF2413	2242..>2378	CDD:287302
Arhgef15	XP_008766014.1	RhoGEF	431..607	CDD:279015	45/205 (22%)
Arhgef15	XP_008766014.1	PH_ephexin	631..751	CDD:269929	32/168 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810