Protein Alignment RhoGEF2 and ARHGEF16

DIOPT Version :9

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: XP_016856538.1
• Gene: ARHGEF16 / 27237
• HGNCID: 15515
• Length: 726
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 120/623 - (19%)
• Similarity: 209/623 - (33%)
• Gaps: 184/623 - (29%)

  Fly  1359 KHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSA 1423
            :|:|...:|         ||.:..|...:....||.|....|...|.|       |....:|.
Human   121 RHQSFGAAV---------LSREAARRDPKLLPAPSFSLDDMDVDKDPG-------GMLRRNLR-- 167

  Fly  1424 GGSESPSTSMEHFAAPGAAG-GVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGS-- 1485
              ::|...:|:....||..| .:|:.|......:.|.   |.|.:...:.........|..||
Human   168 --NQSYRAAMKGLGKPGGQGDAIQLSPKLQALAEEPS---QPHTRSPAKNKKTLGRKRGHKGSFK 227

  Fly  1486 ----------SAASNSSFWNAGHPLPVARWTLESEDEDDVNEAD--------------------- 1519
                      ....|:|               :..|:|.::|:.
Human   228 DDPQLYQEIQERGLNTS---------------QESDDDILDESSSPEGTQKVDATIVVKSYRPAQ 277

  Fly  1520 --WSSM---VAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHL 1579
              ||.:   |...:|..|:..|:||||.:.||..:|                       .|..|.
Human   278 VTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSE-----------------------FSYQHS 319

  Fly  1580 LLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLA-------DMFDGQSGVVLCEFAAQ 1637
            |.:.....|..:|:.....|      :||:|:.:.|.|:|.       |:.......||.|..:.
Human   320 LSILVEEFLQSKELRATVTQ------MEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISD 378

  Fly  1638 ---------------FCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQR 1687
                           :|:.:......|::..:.:...::.|::.|...||..|.:...|...:||
Human   379 ILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQR 443

  Fly  1688 LTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDR 1752
            :|:.|||.:.|...|    ..::...:|..||:::..:::.:.|:.....|...::..:..:||.
Human   444 VTRLPLLMDTLCLKT----QGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDF 504

  Fly  1753 SSYDKEEFKKLDL--TQHHLIHDGNL----------TIKKNPSVQLHGLLFENMIVLLTKQDDKY 1805
            |     :.|.|.|  ....|:..|.|          .|...|:..|  .||.:::|:..|:.::.
Human   505 S-----KVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYL--FLFNDVLVVTKKKSEES 562

  Fly  1806 YLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKH 1870
            |:.                          |:.|..|...:.|::.|   ||..|......:...|
Human   563 YMV--------------------------QDYAQMNHIQVEKIEPS---ELPLPGGGNRSSSVPH 598

  Fly  1871 -FSDVAARQSKNRSKNASSNHDTSISDPA--LAAIPHS 1905
             |.....|.|:.|.:....:.| |.||.|  :.|:.||
Human   599 PFQVTLLRNSEGRQEQLLLSSD-SASDRARWIVALTHS 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	41/213 (19%)
		PH_RhoGEF	1770..1875	CDD:275411	21/115 (18%)
		DUF2413	2242..>2378	CDD:287302
ARHGEF16	XP_016856538.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810