DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Plekhg5

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_006538986.1	Gene:	Plekhg5 / 269608	MGIID:	2652860	Length:	1103	Species:	Mus musculus

Alignment Length:	1240	Identity:	247/1240 - (19%)
Similarity:	412/1240 - (33%)	Gaps:	408/1240 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1180 HCTDCKLNIHRQCSKVVDESCPGPL---------------PQAKRLAHNDKISKFMGKIRPRTSD 1229
            |..||: .:|.:....:.|:|....               ||...||.|....    ...||||.
Mouse    73 HHADCQ-QLHHRGPLNLCETCDSKFHSTLHYDGHVRFDLPPQGSVLARNVSTR----SCPPRTSP 132

  Fly  1230 VIGNEKRSRQDEELDVELTPDRGQA--SIVRQPSDRRP-------------DANISIRSNGNTSC 1279
            ....|    ::||...:...||..|  .|.::.:.||.             |.|:.|.
Mouse   133 AADLE----EEEEGCTDGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIE------- 186

  Fly  1280 NTSGLNTTDLQSSFHGSCANDSINPG--------GGAGCNMDLSTSVASTT-------------- 1322
                   |::..:.......:.:.|.        |.....:|.|.:..|.|
Mouse   187 -------TEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVK 244

  Fly  1323 --PSTSGSVAAGL--SAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNR 1383
              |...|.|..|:  |....|.||              .|.....|||        ||:..:..|
Mouse   245 AKPGDEGKVEQGVKDSKSLSLPAL--------------RPSGAGPPVS--------ERVDPQSRR 287

  Fly  1384 NS---------RRKTSDPSLSS---------RPNDEQLDLGLSNATYVGSSNSSLSSAGG----- 1425
            .|         |||.....|..         .|:...|.:|.|..|..|.:.|..:.|..
Mouse   288 ESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFSGF 352

  Fly  1426 -SESPSTSMEHFAAPGAAGGVQVPPM-GLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAA 1488
             |.|||||         |...:|..| .|....|.:.|.               ||.........
Mouse   353 FSSSPSTS---------AFSREVDKMEQLESKLHAYSLF---------------GLPRMPRRLRF 393

  Fly  1489 SNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKK-------RQEIINEI 1546
            .:.|            |  |.|:|||..:.:.|.:...:....|||..:|       :||.:.|:
Mouse   394 DHDS------------W--EEEEEDDEEDEESSGLRLEDSWRELTDGHEKLTRRQCHQQEAVWEL 444

  Fly  1547 YQTERNHVRTLKLLDRLF---FLPLYESGLLSQDHLLLLFP--PALLSL-REIHGA-----FEQS 1600
            ..||.:::|.|:::..||   .|.|.|||||.:.....||.  |.:..| |.:.|:     .|::
Mouse   445 LHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKA 509

  Fly  1601 LKQRRIEHNHVVNTIGDLLA--DMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLL 1663
            .:.|.:...      .|.|.  .||..     |.:...::|..::..:|.::.....:::.:..:
Mouse   510 RRTRALLQP------SDFLKGFKMFGS-----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYV 563

  Fly  1664 KKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILV 1728
            ..:|.|:.|:||:|.|:|....|||||||||.:::.:.|     ::....|||...:.|.:|.:.
Mouse   564 TWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKT-----DDPRTKEAIVTMISSVERFIH 623

  Fly  1729 EVNQAVKTAEDAHKLQNIQRKLD--------RSSYDK--EEFKKLDLT----------QHHLIHD 1773
            .||..::..::..:|..:..::|        ....||  :||..||||          ...|:.:
Mouse   624 HVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLE 688

  Fly  1774 GNLTIK--KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQE 1836
            |:|.:|  |:..:.::..||.::: |:||...|          :...|.:.|.:.:  |.::.:|
Mouse   689 GSLRMKEGKDSKMDVYCFLFTDLL-LVTKAVKK----------AERTKVIRPPLLV--DKIVCRE 740

  Fly  1837 AADKNSFFLIKMKTSQ----MLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDP 1897
            ..|..||.||.:....    ....:|.|.:.|::|.....:...:..:.|::.::..|
Mouse   741 LRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYNAQNQLQQLRAQLSAQEH------- 798

  Fly  1898 ALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRN 1962
                 |.|...:|||...|
Mouse   799 -----PGSQHLQSLEEEED---------------------------------------------- 812

  Fly  1963 PQRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQSTRES- 2026
             :::....||.....::|                    .|.:.|:|..::...|...|..|...
Mouse   813 -EQEEEGEESGTSAASSP--------------------TILRKSSNSLDSEHCTSDGSTETLAMV 856

  Fly  2027 -VRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNN---TRTLLMQSPL-------------VD 2074
             |.||:|........|.|  :|:.|.:|:  ||.:::   |..||...|:             :.
Mouse   857 VVEPGATLSSPEFEGGPV--SSQSDESSL--SNTASSVTPTSELLPLGPVDGRSCSMDSAYGTLS 917

  Fly  2075 PTAIQVSISPAHTAEPVLT-------PGEKLRRLDASIRNDLLEKQKIICDIFRLPVEHYDQIVD 2132
            ||::|..::|....||...       |..:|||                    |.||:
Mouse   918 PTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRR--------------------RTPVQ------- 955

  Fly  2133 IAMMPEAP---KDSADIAL--------AAYDQIQTLTKMLNEYMHVT---------PEQEVSA-- 2175
              ::|..|   |..::.:|        ||.......::.|:|...::         |.||...
Mouse   956 --LLPRPPRLLKSKSEASLLQLLSGTPAARGVPPAPSRSLSELCLISVAPGVRTQRPLQEGGPGW 1018

  Fly  2176 VSTAVCGHCH-------EKEKLRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQIPPSRLMPKLQTL 2233
            ....:|..||       |.........|:.|.......:|.......|::   |||.:..:.:.|
Mouse  1019 NGPGMCDPCHGPQLSESENRPSHMTGGPADSARRRCREMPSGTMSRVQSE---PPSGVSAQHRKL 1080

  Fly  2234 DLDEV 2238
            .|.::
Mouse  1081 TLAQL 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	6/21 (29%)
		RhoGEF	1539..1731	CDD:238091	54/204 (26%)
		PH_RhoGEF	1770..1875	CDD:275411	24/110 (22%)
		DUF2413	2242..>2378	CDD:287302
Plekhg5	XP_006538986.1	RBD_PLEKHG5	172..246	CDD:340588	10/87 (11%)
		RhoGEF	440..626	CDD:214619	52/201 (26%)
		PH_PLEKHG5_G6	683..781	CDD:270064	24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910