DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and TIAM2

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_001371475.1 Gene:TIAM2 / 26230 HGNCID:11806 Length:1701 Species:Homo sapiens


Alignment Length:2052 Identity:383/2052 - (18%)
Similarity:675/2052 - (32%) Gaps:621/2052 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 RDRTASITGPQPVD-SIKRREMETYKIQTLQKMLEQEKLNLERLKSDQNNPSYK---LSEANIRK 417
            ::.:.:|||.:.:. |:|.|.:..           :|:.:|.......|...||   |:.:.:..
Human    14 KNHSNTITGAKQIPCSLKIRGIHA-----------KEEKSLHGWGHGSNGAGYKSRSLARSCLSH 67

  Fly   418 LREQLHQVGAEDAPTVKLQAAAGNKNTALLTPNQ-IQHLSASATHSNQQFHHLHHH--------- 472
            .:...........||.|:.............|.: .|.:||:.:..| .||.:.|.         
Human    68 FKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTEN-GFHSVGHELADNHITSR 131

  Fly   473 ----HNLHNNNYPPQQQPASTSPAFLSLLPRSLSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQ 533
                |.|  |.|...:..|||.|......||.|.. :||....            .|..:|    
Human   132 DCNGHLL--NCYGRNESIASTPPGEDRKSPRVLIK-TLGKLDG------------CLRVEF---- 177

  Fly   534 RMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQ 598
               |...:.|:...:..|.|.....:.|...    .||.|..:.:      |....:.:|...|.
Human   178 ---HNGGNPSKVPAEDCSEPVQLLRYSPTLA----SETSPVPEAR------RGSSADSLPSHRPS 229

  Fly   599 RNPPRQLNLDLKNGNA---------SPGGSHLVAPVSDLDRA---------TSPQLNRSQQQQLP 645
               |....|....|::         ||.|:     ..:|..|         ..|.|:.|    .|
Human   230 ---PTDSRLRSSKGSSLSSESSWYDSPWGN-----AGELSEAEGSFLAPGMPDPSLHAS----FP 282

  Fly   646 SSTDNSPSNAKSKRSKIKTK--------------ALSDPKMSTQMFLQMESASAAGAAGGSIEVD 696
            ......|.|..|..|.::..              .|||..|.|...|....:.|:.....|....
Human   283 PGDAKKPFNQSSSLSSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAH 347

  Fly   697 GGPP-----PLPPRLPGMMTEDMSR---------------GSC----QNLAQPNSVGTAFNYPLV 737
            |.|.     .||.|.|....||.::               ||.    :.|.:|.|...:..:.  
Human   348 GDPIQYSSFTLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFD-- 410

  Fly   738 STTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQQHQMSGG---------QATGALGQTP---NL 790
                 .::|.||            ..:|...|......|||         ::|.|:|..|   |:
Human   411 -----SRSDGLN------------TDVQGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNI 458

  Fly   791 GKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPNEN 855
            .:|..|.:..|..|         |:....|.|..|...||          |||  :..|:...|.
Human   459 YENFMRELEMSRTN---------TENIETSTETAESSSES----------LSS--LEQLDLLFEK 502

  Fly   856 NRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQKEII--------------- 905
            .:|.......:|     |.|:........:.|      .|:....|..:.               
Human   503 EQGVVRKAGWLF-----FKPLVTVQKERKLEL------VARRKWKQYWVTLKGCTLLFYETYGKN 556

  Fly   906 SMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTS 970
            || |::|........|:....::....:.|||        :.:|||.....||        :.||
Human   557 SM-DQSSAPRCALFAEDSIVQSVPEHPKKENV--------FCLSNSFGDVYLF--------QATS 604

  Fly   971 K-DMRKWAYEIHSTFLVPRAPLSWYRQDES-------LAREVDNVLQ-LEYD----KVEILRTVF 1022
            : |:..|...:||      |..|.:.:...       |..:..|:|| ::.|    |:..|:...
Human   605 QTDLENWVTAVHS------ACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSV 663

  Fly  1023 LRSRKRAKDLISEQLREFQQ----------KRTAGLGTIYG---PTDDKL--AEAKTDKLREQII 1072
            :...|..| .|..|:::::|          :....|.::.|   |....|  |.::..||....:
Human   664 VSDPKNRK-AIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRL 727

  Fly  1073 DKYLMPNLHALIEDENGSPPEDVRKVAL---------------CSALSTVIYRIFNTRPPPSSIV 1122
            ....:.:.|||:...:.|.   :||..|               ...|.|:..:....||..:.:.
Human   728 GILSVSSFHALVCSRDDSA---LRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKEKRPSITQVD 789

  Fly  1123 ERVHHF------VSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHC 1181
            |.:|.:      |.||.:::.                   |.|.....||..|:  |:.|: :..
Human   790 ELLHIYGSTVDGVPRDNAWEI-------------------QTYVHFQDNHGVTV--GIKPE-HRV 832

  Fly  1182 TD-----CKL------NIHRQCSKVVD---ESC-PGPLPQAKRLAHNDKISKFMGKIRPRTSDVI 1231
            .|     ||:      :...|..|:||   |.| |.|....::..: |:|..|...:        
Human   833 EDILTLACKMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVY-DEIEVFPLNV-------- 888

  Fly  1232 GNEKRSRQDEELDVELTP-----DRGQASIVRQPSDRRPDANISIRS-------------NGNTS 1278
                       .||:||.     |.|.| :..|..:|:..:.|.|..             .||..
Human   889 -----------YDVQLTKTGSVCDFGFA-VTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEI 941

  Fly  1279 CNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALD 1343
            ...:|...:||......:..::.           .:..::.:..|.|..::....|        |
Human   942 MTLNGEAVSDLDLKQMEALFSEK-----------SVGLTLIARPPDTKATLCTSWS--------D 987

  Fly  1344 TVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLS 1408
            :       :.:|:..|....|  .|:|:..:|.|.|.:...:...::.|.:::.....|.|..|.
Human   988 S-------DLFSRDQKSLLPP--PNQSQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQTDGTLD 1043

  Fly  1409 NATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQD 1473
            ..::......:..||    ...|::........|.|::.|    .:||.|               
Human  1044 QVSHREKMEQTFRSA----EQITALCRSFNDSQANGMEGP----RENQDP--------------- 1085

  Fly  1474 SFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKK 1538
                                    .|..:||                          .|:||::.
Human  1086 ------------------------PPRSLAR--------------------------HLSDADRL 1100

  Fly  1539 RQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFP--PALLSLREIHGAFEQSL 1601
            | ::|.|:..||:::|:.|..|..|:..||.....|:||.:..||.  |.:|..:::   |.::|
Human  1101 R-KVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKV---FLETL 1161

  Fly  1602 KQRRIEHNHVVNTI--------------GDLL--ADMFDGQSGVVLCEFAAQFCARQQIALEALK 1650
            :. .|..:...||:              |..|  ||.|...||         ||| ..|.::.:.
Human  1162 ED-GISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG---------FCA-NHIKVQKVL 1215

  Fly  1651 EKRNKDEMLQKLL---KKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTE 1712
            |:...|:..:..|   ..::.|.:    .|:..|...:||:.|||||.:.|    |.|..:.:.|
Human  1216 ERAKTDKAFKAFLDARNPTKQHSS----TLESYLIKPVQRVLKYPLLLKEL----VSLTDQESEE 1272

  Fly  1713 AEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKE--EFKKLDLTQHHLIHDGN 1775
            ...:..|:::.:::...:|:..|..||...:.: |...::|..:||  |....:|..|..:...|
Human  1273 HYHLTEALKAMEKVASHINEMQKIYEDYGTVFD-QLVAEQSGTEKEVTELSMGELLMHSTVSWLN 1336

  Fly  1776 --LTI-KKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEA 1837
              |:: |....::|...:|:..::|:.|::.|     |...|...::|.             ..:
Human  1337 PFLSLGKARKDLELTVFVFKRAVILVYKENCK-----LKKKLPSNSRPA-------------HNS 1383

  Fly  1838 ADKNSF---FLIKMKTSQMLELRAPSSSECKTWFKHF---SDVAARQ--------SKNRSKNASS 1888
            .|.:.|   :||.:...| :.|..|:.:|..:.::..   |::..|.        |.:.||    
Human  1384 TDLDPFKFRWLIPISALQ-VRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESK---- 1443

  Fly  1889 NHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPI----ATVTPAPATNN 1949
               |:|     ..:..|..:|:.........||..|......||...:|:    |:........|
Human  1444 ---TNI-----VKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKN 1500

  Fly  1950 SNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEP-IQKYSANGTEAN 2013
            |:.:..||...:....|:......:...::..|.:...:.:::.|......| :..::.|..:.:
Human  1501 SSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKES 1565

  Fly  2014 DVTLRHSQSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVDPTAI 2078
            |:........|::|:.||..::....:                      .|..:.:.|.|.|.|.
Human  1566 DILSDEDDDHRQTVKQGSPTKDIEIQF----------------------QRLRISEDPDVHPEAE 1608

  Fly  2079 QVSISPAHTA--------EPVLTPGE--KLRRLDASIRND---LLEKQKIICDIFRLPVEHYDQI 2130
            |   .|...:        :|.|..|.  .::|...|.:.|   ||:.|          :.|  |.
Human  1609 Q---QPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQ----------IRH--QS 1658

  Fly  2131 VDIAMMPEAPKDSADIALAAYDQ----IQTLTKMLNE 2163
            :|      :..::|.|.|.:..:    :|:||.:::|
Human  1659 LD------SQSENATIDLNSVLEREFSVQSLTSVVSE 1689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710 30/146 (21%)
C1_1 1151..1202 CDD:278556 16/65 (25%)
RhoGEF 1539..1731 CDD:238091 52/212 (25%)
PH_RhoGEF 1770..1875 CDD:275411 20/113 (18%)
DUF2413 2242..>2378 CDD:287302
TIAM2NP_001371475.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 0/6 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..250 10/61 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..293 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..417 5/34 (15%)
PH1_Tiam1_2 505..631 CDD:269937 28/159 (18%)
Tiam_CC_Ex 645..742 CDD:408184 19/97 (20%)
Ubiquitin_like_fold 811..881 CDD:421700 19/73 (26%)
PDZ_signaling 888..973 CDD:238492 16/115 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1092 7/64 (11%)
RhoGEF 1103..1292 CDD:214619 51/210 (24%)
PH2_Tiam1_2 1294..1466 CDD:269957 38/203 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1500..1556 8/55 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1568..1628 12/84 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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