DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and ARHGEF26

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_001238891.1 Gene:ARHGEF26 / 26084 HGNCID:24490 Length:871 Species:Homo sapiens


Alignment Length:751 Identity:135/751 - (17%)
Similarity:262/751 - (34%) Gaps:214/751 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1201 PGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEEL----DVELTPDR------GQAS 1255
            ||...|:.|.|.:.:...|.|..:..:...:..::...|:.||    .|.|:.:.      |:..
Human   185 PGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSPAALKVGKQQ 249

  Fly  1256 IVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVAS 1320
            |:  |.....:..||..:|.|...:...|....:.....|        |.|.||...::...|.|
Human   250 II--PKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGG--------PLGHAGEESEVDNDVDS 304

  Fly  1321 TTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERL-------- 1377
                 .||:..||                                   ||.||:..:        
Human   305 -----PGSLRRGL-----------------------------------RSTSYRRAVVSGFDFDS 329

  Fly  1378 ---SNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAP 1439
               |.|:||     .|.|.|.....|:                                |.|::.
Human   330 PTSSKKKNR-----MSQPVLKVVMEDK--------------------------------EKFSSL 357

  Fly  1440 GAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVAR 1504
            |......:...|....:...:|.|.:.::....||.:                            
Human   358 GRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDE---------------------------- 394

  Fly  1505 WTLESEDEDDVNE-----------ADWSSMVAAE---VLAALTDAEKKRQEIINEIYQTERNHVR 1555
               |||.::..::           :.||.:.|.:   :...::..|:||||.|.|:..:|.:::.
Human   395 ---ESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLL 456

  Fly  1556 TLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLK-----QRRIEHNHVVNTI 1615
            :|::|.|:|......|..:::.....||       ..|....|.|.|     :.|.::|..::.|
Human   457 SLEILIRMFKNSKELSDTMTKTERHHLF-------SNITDVCEASKKFFIELEARHQNNIFIDDI 514

  Fly  1616 GDLL----ADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLE 1676
            .|::    |..||..         .::|..:......|::....:...:::|.:.|||:.||.|.
Human   515 SDIVEKHTASTFDPY---------VKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLP 570

  Fly  1677 LKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAH 1741
            :...|...:||:|:.|||.:.:.:.|    |:::.:.|..:||::...:::...|:..:..|...
Human   571 MISFLILPMQRVTRLPLLMDTICQKT----PKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTE 631

  Fly  1742 KLQNIQRKLDRSSYDKEEFK----KLDLTQHHLIHDGNLTI---------KKNPSVQLHGLLFEN 1793
            .:..|..:|        |||    .|..:...|:..|.||.         ::....|::..||.:
Human   632 MMYTINSQL--------EFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVYFFLFND 688

  Fly  1794 MIVLLTKQDDKYYLKN---LHTPL---SITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQ 1852
            ::::..|:.::.|..|   |...|   |..|:.::.....::.|::....:..:..|.:.:.::.
Human   689 VLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNH 753

  Fly  1853 MLE-----LRAPSSSECKTWFKHFSDVAARQSKNRS 1883
            ..|     |.|.:.||...|.......:.:...:|:
Human   754 ANEKVEMLLGAETQSERARWITALGHSSGKPPADRT 789

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710