DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and rgf2

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_594853.1	Gene:	rgf2 / 2542953	PomBaseID:	SPAC1006.06	Length:	1158	Species:	Schizosaccharomyces pombe

Alignment Length:	783	Identity:	154/783 - (19%)
Similarity:	275/783 - (35%)	Gaps:	210/783 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1235 KRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCAN 1299
            :||...::..:.....|.:...:.:|..|: ..::|..|||::..|..       ::|.|.:...
pombe   102 RRSSSTDDFGISHARSRKEIQSLGRPHTRQ-SFSVSDVSNGSSYPNIR-------KNSVHVNAPM 158

  Fly  1300 DSINPGGGA-----GCNMDLSTSVASTTPSTSGSVAA---------------------------- 1331
            .|...|..|     ......::::::..||.|.|.::
pombe   159 PSFPEGSTAVLLKHHSGSKSASAISNIAPSHSNSTSSRRPYIHPAFLSQVAVEFRKRLNIGDRVK 223

  Fly  1332 -GL---SAFAELNALD-------TVD--------------------------KEARRERYSQHPK 1359
             ||   .||....|:|       |.|                          :::.:|.| |:.:
pombe   224 DGLLYKDAFLGSEAVDVLMHIVRTTDRNLALLLGRALDSQKMFHDVTYSHRLRDSLKEVY-QYRR 287

  Fly  1360 HKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGS---SNSSLS 1421
            ..|.|..::..:|....:.|......||..:..|..|..:|......:|::..|.|   ..||||
pombe   288 IISPPPGLSSMDSNGSSIENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLS 352

  Fly  1422 S-AGGSESPSTS----------MEHFAAPGAAGGVQVP---PMGLNQNQHPHLLIQQHAQQYCQQ 1472
            : ....|:|.|.          .|.:::..:...:...   |..|.|....||.:
pombe   353 AITKEPEAPETEYNPHGVFTLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKV---------- 407

  Fly  1473 DSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEK 1537
               |..|:|  ||::.:                     |:.:.:...||..|..:|:..:...|.
pombe   408 ---QPVLSG--GSTSIT---------------------DKQEEDHRLWSENVPKQVVDQIDVREW 446

  Fly  1538 KRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQ--S 1600
            ||||||.|:..|||:.||.|:.:...:..||..|.::.:::..........::.:||....:  :
pombe   447 KRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQFIRCVFHNIMQIHAVNSRLSN 511

  Fly  1601 LKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKK 1665
            ...|......||||||||..|.      |...|...::.|.|.||....:.:::.:......:.:
pombe   512 ALNRTQTLQPVVNTIGDLFLDY------VPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHE 570

  Fly  1666 SESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEV 1730
            .|..:..|:|||...|.....||.:||||...:.|.|    .::..:.|.|.|.:|..:..|.::
pombe   571 VERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYT----DKDNPDTENIPRVIEMIREFLTKL 631

  Fly  1731 NQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLIHDGNLTIK----KNPSVQ--LHGL 1789
            |......|:...|..:..:|..|..|:.:....| ....||..|.:.:|    .|...:  :|..
pombe   632 NYETGKTENRLSLLQLNEQLSCSPADRAKLTLFD-PSRLLIFKGVVKLKASSYSNGDTENDIHMF 695

  Fly  1790 LFENMIVL------LTKQDDKYYLKN----------------------------LHTPLSITNKP 1820
            |.:|.::|      :.::..|.:|:.                            |..|:|||...
pombe   696 LLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSISYIEDSPSRGSLPRRPSSALLTNPISITKSN 760

  Fly  1821 VSPI----------------MSIDADTLIRQEA----ADKNSFFLIKMKTSQMLELRAPSSSECK 1865
            ..|:                :|:..:|||.::.    .:|....:  .|...:.|.|...   |:
pombe   761 PPPVKAYGLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDII--RKRHLVFESRGIC---CQ 820

  Fly  1866 TWF 1868
            :||
pombe   821 SWF 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	52/193 (27%)
		PH_RhoGEF	1770..1875	CDD:275411	28/159 (18%)
		DUF2413	2242..>2378	CDD:287302
rgf2	NP_594853.1	ROM1	1..1148	CDD:227709	154/783 (20%)
		DEP_fRom2	204..285	CDD:239882	10/81 (12%)
		RhoGEF	451..632	CDD:279015	49/190 (26%)
		PH_5	670..802	CDD:292048	22/131 (17%)
		CNH	831..1117	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9310
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810