DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and rgf3

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_588115.1	Gene:	rgf3 / 2539437	PomBaseID:	SPCC645.06c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	908	Identity:	177/908 - (19%)
Similarity:	321/908 - (35%)	Gaps:	255/908 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1232 GNEKRSRQDEELDVELTPDRGQASIVRQ-PSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHG 1295
            || |::..|....:..||.....|:|.. |   ||....|:.|:.:....||..:...|.:....
pombe   144 GN-KQNTVDSFRPLPETPVSPGGSLVHPLP---RPPLPSSVSSHSSPYSTTSSTSLYSLYNDISL 204

  Fly  1296 SC------------------------ANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAF 1336
            ||                        ::|::.|      ...||.||...||....|:.:.:|:.
pombe   205 SCSPEPYLPLSPTRSPARTPSPIRLYSSDALRP------QSPLSPSVEYLTPPNPYSLKSDISST 263

  Fly  1337 AELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKT-----SDPSLSS 1396
            .:|                  ||   .||....|......|..:.:|.::.:|     .:|.|..
pombe   264 RQL------------------PK---IPVQDYASGKISSPLITRTHRRAQSETLFSSCREPWLVG 307

  Fly  1397 RPN---DEQLDLGLSNATYVGSSNSSLSSAGGS--ESPSTSMEHFAAPGAA----------GGVQ 1446
            :..   .|::...|....:.|.|...::....:  .....|||...|...|          |.|:
pombe   308 KLYKWCKEEVFTALGGLVHEGVSRREVAQVMATLFTIHIASMEFLIAEIIAKNILGDWINYGLVE 372

  Fly  1447 V--------------PPMG-------LNQNQHPHLLIQQHA----QQY---CQQDSFQAGLAGAA 1483
            |              ||.|       .|...:.::...:..    |.|   |.::| ........
pombe   373 VINLEKLQIAFTSNEPPSGSGVLPFLTNGGCYSYICRSRSCPSKYQCYSCRCARNS-SLEFTSLP 436

  Fly  1484 GSSAASNSSFWNAG--HPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEI 1546
            |.|:.:.|.|||..  :.||                            ::|:..|..||..|:|:
pombe   437 GQSSDTWSIFWNISSLNSLP----------------------------SSLSKREIARQNNIHEL 473

  Fly  1547 YQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPA-------------LLSLREIHGA-- 1596
            ...|.::|..|..|..||     ..|::.|...::   |:             :.|:|::|..
pombe   474 ICKESDYVADLNTLAELF-----RDGIVQQQDAIV---PSNRVADFIQSVFGNVESIRQLHSRLF 530

  Fly  1597 FEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQK 1661
            ..|.:.:.|:: ..||:.|||:|.:.........: .:|.||    .:|.|..|.:..::....:
pombe   531 LPQLIMRERLQ-GPVVSIIGDILLEWIHAAKSSYI-NYAKQF----PLADETYKLECQRNTYFAR 589

  Fly  1662 LLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRI 1726
            .|....|...||||:.:..|....|||.:|.|..:.:.|.|    .:::.:.:.|.:||:..:..
pombe   590 WLAACRSDPRCRRLDFQHFLQRPTQRLQRYTLELDTILKHT----EQSSWDFQLITQAVKELRAT 650

  Fly  1727 LVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDL--TQHHLIHDGNLTIKKNPS----VQ 1785
            ..|.:..:.|..:|::::::..:|   .:...|...|:|  .:.....:| :..:::.|    :.
pombe   651 CEECDAVIATVLEANRIRDLSYQL---LFKNHESVNLELRDPEREFFFEG-IVQRRSDSRLDWLD 711

  Fly  1786 LHGLLFENMIVLLTKQDDKYYLKNLHTPLS---ITNKPVSPIMSIDADTLIRQEAADKNSFFLIK 1847
            :|..|.:|.:::...:.||      .|..|   ::.:|: |:     |.|:.....|.   |.:|
pombe   712 IHLFLLDNYLIMAKARKDK------RTNASRYVVSKRPI-PL-----DLLVLSPKMDD---FQLK 761

  Fly  1848 MKTSQMLELRA---PSSSECKTWFKHFSDVAARQSKNRSK---------NASSNHDTSISDPALA 1900
            ..|::.|...|   |..|            ...:||.:||         .|..|::.|:
pombe   762 SNTNKFLGSLAGNLPQES------------LTTKSKRKSKVNLELMFDATAEKNNENSM------ 808

  Fly  1901 AIPHSNTKESLELSTDTVQPLAA-TATLTTTPLAPMLP---IATVTPAPATNNSNVSSLTGVQLR 1961
               :|...|..:|...|::.|.| ||:.|....:..|.   :..:..|...::..::      ::
pombe   809 ---NSAVFEKSQLYPFTIRHLGAYTASYTLYVESLQLRKLWVEKINVAKKRHSQKIN------IK 864

  Fly  1962 NP-----QRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRH 2019
            ||     ..|.......:|.||..:|.:|.||:...     .|..|.:      ..|:|..:|
pombe   865 NPFALKVVSDVAFQYPPSDLVNGNEPLNSFNEITLV-----EGSSIDR------ALNEVAWKH 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	48/206 (23%)
		PH_RhoGEF	1770..1875	CDD:275411	21/114 (18%)
		DUF2413	2242..>2378	CDD:287302
rgf3	NP_588115.1	RhoGEF	470..656	CDD:279015	46/203 (23%)
		PH-like	695..850	CDD:302622	38/191 (20%)
		CNH	939..1236	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9310
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810