Sequence 1: | NP_477317.1 | Gene: | RhoGEF2 / 36915 | FlyBaseID: | FBgn0023172 | Length: | 2559 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_056128.1 | Gene: | ARHGEF12 / 23365 | HGNCID: | 14193 | Length: | 1544 | Species: | Homo sapiens |
Alignment Length: | 2246 | Identity: | 473/2246 - (21%) |
---|---|---|---|
Similarity: | 742/2246 - (33%) | Gaps: | 900/2246 - (40%) |
- Green bases have known domain annotations that are detailed below.
Fly 263 VRKDSNGYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTT 327
Fly 328 VELAVK----------RSQKLTRPSSVS-----VVTPSTPILSGRDRTASITGPQPVDSIKRREM 377
Fly 378 ETYKIQTLQKMLEQEKLNLERLKSDQN-NPSYKL------SEANIRKLREQLHQVGAEDAPTVKL 435
Fly 436 QAAAGNKNTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSLLPRS 500
Fly 501 LSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQ 565
Fly 566 HRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDR 630
Fly 631 ATSPQLNRSQQQQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQMESASAAGAAGGSIEV 695
Fly 696 DGGPPPLPPRLPGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQNDNLNIAFPLSQRPNI 760
Fly 761 VQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVE 825
Fly 826 KDGESSPPGTPPPPYLSSSHMTVLEDPNENNRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSS 890
Fly 891 HMHAAQSNDTQKEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAP 955
Fly 956 LLFYLITELYKEGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEIL-- 1018
Fly 1019 ---RTVFLRSRKRAKDLISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKL-REQIIDKYLMPN 1079
Fly 1080 LHALIEDENGSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNR 1144
Fly 1145 KMNVRGHPLVLRQYYEVTHCNHCQTIIWGV---SPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQ 1206
Fly 1207 AKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISI 1271
Fly 1272 RSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAF 1336
Fly 1337 AELNALDTVDKEARRERYSQHPKHKSAPVSVN--RSESYKERLSNKRNRNSRRKTSDPSLSSRPN 1399
Fly 1400 DEQLDLGLSNATYVGS--SNSSLSSAGGSESPSTSME--HFAAPG-AAGGV--------QVPPMG 1451
Fly 1452 LNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLP------VARWTLESE 1510
Fly 1511 DEDDVNEAD-----WSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYE 1570
Fly 1571 SGLLSQDHLLLLFPPALLSLREIH-GAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEF 1634
Fly 1635 AAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLY 1699
Fly 1700 KVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY------DKE 1758
Fly 1759 EFKKLDLTQHHLIHDGNLT--IKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPL----SIT 1817
Fly 1818 NKPVSPIMSIDADTLIRQEAADKNSFFLIKMKT--SQMLELRAPSSSECKTWFKHFSDVAARQSK 1880
Fly 1881 NRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAP 1945
Fly 1946 ATNN----------SNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGE 2000
Fly 2001 PIQKYSANGTEANDVTLRHSQSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRT 2065
Fly 2066 LLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKIICDI------FRLPV 2124
Fly 2125 EHYDQIVDIAMMPEAPKDSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHCHEKEK 2189
Fly 2190 LRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQIPPSRLM--PKLQTLDLDEVAIHEDDDGYCEIDE 2252
Fly 2253 LRLPAIPSKPHERPTTPLAPFNTEPKTSQSVI----------DASKRQSTDAVPEGLLEQEPLEG 2307
Fly 2308 DKT--ETKGEDNEVKTVPSD-KLSESCNE----------ERQCVEADITKEVADPTTSKNEAAAS 2359
Fly 2360 VDELPSQSREIKTAEN---------ASKSVADKKED 2386 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
RhoGEF2 | NP_477317.1 | PDZ | 260..334 | CDD:214570 | 38/80 (48%) |
RGS_GEF_like | 934..1055 | CDD:188710 | 40/125 (32%) | ||
C1_1 | 1151..1202 | CDD:278556 | 7/53 (13%) | ||
RhoGEF | 1539..1731 | CDD:238091 | 78/192 (41%) | ||
PH_RhoGEF | 1770..1875 | CDD:275411 | 35/112 (31%) | ||
DUF2413 | 2242..>2378 | CDD:287302 | 31/167 (19%) | ||
ARHGEF12 | NP_056128.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..62 | ||
PDZ_signaling | 71..145 | CDD:238492 | 37/69 (54%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 247..346 | 32/268 (12%) | |||
RGS_LARG | 349..570 | CDD:188708 | 76/496 (15%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 570..706 | 55/261 (21%) | |||
RhoGEF | 791..976 | CDD:279015 | 76/190 (40%) | ||
PH_LARG | 995..1132 | CDD:275425 | 45/162 (28%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1138..1179 | 11/68 (16%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 138 | 1.000 | Domainoid score | I4844 |
eggNOG | 1 | 0.900 | - | - | E1_COG5422 | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 332 | 1.000 | Inparanoid score | I2429 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D163264at33208 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0001574 | |
OrthoInspector | 1 | 1.000 | - | - | otm41901 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_106011 | |
Panther | 1 | 1.100 | - | - | O | PTHR45872 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3275 |
SonicParanoid | 1 | 1.000 | - | - | X2399 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
13 | 12.860 |