DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and FGD1

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_004454.2	Gene:	FGD1 / 2245	HGNCID:	3663	Length:	961	Species:	Homo sapiens

Alignment Length:	969	Identity:	186/969 - (19%)
Similarity:	305/969 - (31%)	Gaps:	348/969 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1389 TSDPSLSSRPNDEQ------LDLGLSNATYVGSSNSSLSSAGGSESPSTSME-----------HF 1436
            ||.|.:...|..|.      |..|..:...|.:.:|.:.|.   .|||.|.|           |.
Human   248 TSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSI---SSPSNSEETCFVSDDGPPSHS 309

  Fly  1437 AAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLP 1501
            ..||......| |:.|.....|                         ||....:.
Human   310 LCPGPPALASV-PVALADPHRP-------------------------GSQEVDSD---------- 338

  Fly  1502 VARWTLESE-DEDDVNEADWSSMVAAEVLAALTD--------AEKKRQEIINEIYQTERNHVRTL 1557
                 ||.| ||::..|.|      .|:...|.:        .::|...|.||:.|||:.:|..|
Human   339 -----LEEEDDEEEEEEKD------REIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRL 392

  Fly  1558 KLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAF----------EQSL---KQRRIEHN 1609
            .|||::|...|.|.......     ||..:     :||.|          :|.|   .::|:|..
Human   393 HLLDQVFCARLLEEARNRSS-----FPADV-----VHGIFSNICSIYCFHQQFLLPELEKRMEEW 447

  Fly  1610 HVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRR 1674
            .....|||:|      |......:...::......|:|.:.....:....:.::.:.:..:||..
Human   448 DRYPRIGDIL------QKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGN 506

  Fly  1675 LELKDLLPTVLQRLTKYPLLFEN-LYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAE 1738
            |.|:..:...:||:.:|.||.:: |.|     ||..:.:::..|:::|.........|.|::..|
Human   507 LTLQHHMLEPVQRIPRYELLLKDYLLK-----LPHGSPDSKDAQKSLELIATAAEHSNAAIRKME 566

  Fly  1739 DAHKLQNIQRKL----DRSSYDKEEFKKLDLTQHHLIHDGNLTIKKNPSVQLHGLLFENMIVLLT 1799
            ..|||..:...|    |..|..||..|     :.|::   .|:.|...:...:.:||.:.::...
Human   567 RMHKLLKVYELLGGEEDIVSPTKELIK-----EGHIL---KLSAKNGTTQDRYLILFNDRLLYCV 623

  Fly  1800 KQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKN--SFFLIKMKTSQMLELRAPSSS 1862
            .:            |.:..:..|....||.|.:..:|:::.|  ..||:..| .:.|||:|.:..
Human   624 PR------------LRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGK-QRSLELQARTEE 675

  Fly  1863 ECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATL 1927
            |.|.|.:..:.                          ..:.|..|.|:.:|...|.:     ...
Human   676 EKKDWVQAINS--------------------------TLLKHEQTLETFKLLNSTNR-----EDE 709

  Fly  1928 TTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRT 1992
            .|.|.:|.:.:....|.|.                                      .:.||  |
Human   710 DTPPNSPNVDLGKRAPTPI--------------------------------------REKEV--T 734

  Fly  1993 MSIRSTGEPIQKYSANGTEANDVTLR--HSQSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIV 2055
            |.:|.. ||.          |.:|.|  |.::...                :|.|......|.:|
Human   735 MCMRCQ-EPF----------NSITKRRHHCKACGH----------------VVCGKCSEFRARLV 772

  Fly  2056 CSNNSNN-----TRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQ-- 2113
            ..||.:|     ....|...|...|...|      ||.:.               |..:||||
Human   773 YDNNRSNRVCTDCYVALHGVPGSSPACSQ------HTPQR---------------RRSILEKQAS 816

  Fly  2114 -----KIICDIFRLPVEHYDQIVDIAMMPEAPK----------DSADIALAAYDQIQTLTKMLNE 2163
                 .:||...     ||        |.:..|          ::..:.|
Human   817 VAAENSVICSFL-----HY--------MEKGGKGWHKAWFVVPENEPLVL--------------- 853

  Fly  2164 YMHVTPEQEVSAVSTAVCGHCHEKEKLRKKVAPSSSFSSSPPPL-PPPNRQHAQAQAQIPPSRL- 2226
            |::..| |:|.|                ::..|...|...||.. ..|:|:|.   .:|..|.|
Human   854 YIYGAP-QDVKA----------------QRSLPLIGFEVGPPEAGERPDRRHV---FKITQSHLS 898

  Fly  2227 ---MPKLQTLDLDEVAI---HEDDDGYC---------EIDELRLPAI--PSKPHERPTT 2268
               .|:.:.|....:|:   ....|.:|         |::|..:.|:  .::|.|.|.|
Human   899 WYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQT 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	45/205 (22%)
		PH_RhoGEF	1770..1875	CDD:275411	21/106 (20%)
		DUF2413	2242..>2378	CDD:287302	9/38 (24%)
FGD1	NP_004454.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..353		31/154 (20%)
		SH3-binding. /evidence=ECO:0000255	171..187
		RhoGEF	376..559	CDD:238091	45/203 (22%)
		PH1_FGD1	591..698	CDD:275392	26/153 (17%)
		PH	591..688	CDD:278594	23/143 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..726		4/28 (14%)
		FYVE_FGD1_2_4	725..789	CDD:277280	20/130 (15%)
		PH2_FGD1-4	815..920	CDD:270056	25/152 (16%)
		PH	823..921	CDD:278594	25/145 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..961		8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810