DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and FGD2

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_016865918.1	Gene:	FGD2 / 221472	HGNCID:	3664	Length:	662	Species:	Homo sapiens

Alignment Length:	732	Identity:	146/732 - (19%)
Similarity:	265/732 - (36%)	Gaps:	185/732 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1414 GSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAG 1478
            |:|...|:|.   .:..|..|:...|.||      |.|       ..|...|.:..|:...
Human     3 GASEEKLASV---SNLVTVFENSRTPEAA------PRG-------QRLEDVHHRPECRPPE---- 47

  Fly  1479 LAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEII 1543
               :.|....:|........|..|:|..|.|......:|| |........|:. :..::..::|:
Human    48 ---SPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEA-WRKSCQPVTLSG-SGTQEPEKKIV 107

  Fly  1544 NEIYQTERNHVRTLKLLDRLFFLPLYESGLLS----QDHLLLLFPPALLSLREIHGAFEQSLKQR 1604
            .|:.:||:.:|..|.|||::||..|.::...|    :|.:.::| ..:.|:.:.|..|.....||
Human   108 QELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIF-SNISSIYQFHSQFFLPELQR 171

  Fly  1605 RIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESH 1669
            |::.......|||::      |......:..:::....:.|.|.|....:|..:.|::|.:.:|.
Human   172 RLDDWTANPRIGDVI------QKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSS 230

  Fly  1670 KACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAV 1734
            :|...|.|:..:...:||:.:|.||.    |..::.||....:....|:|::.........|.|:
Human   231 EASGSLTLQHHMLEPVQRIPRYELLL----KEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAI 291

  Fly  1735 KTAEDAHKLQNIQRKLDRSSYDKEEFKKLDL------TQHHLIHDG---NLTIKKNPSVQLHGLL 1790
            ...|   :||::.          |.:::|.|      ..:.|:.:|   .::.::|..::.:..|
Human   292 TEME---RLQDLW----------EVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFL 343

  Fly  1791 FENMIVLLTKQDDKYYLK-NLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQML 1854
            |.||::....:..:...: .:.|.:.:....|..:|.           |:....||:..| .:.|
Human   344 FNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMD-----------AEFPHSFLVSGK-QRTL 396

  Fly  1855 ELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQ 1919
            ||:|.|..|..:|.:.| ..|..|.:.|::...          |.|..|..:.:|. ||.::.
Human   397 ELQARSQEEMISWMQAF-QAAIDQIEKRNETFK----------AAAQGPEGDIQEQ-ELQSEE-- 447

  Fly  1920 PLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQ--RDATASESDADYVNTPKP 1982
                                                  :.||.||  ||...:..    :...:|
Human   448 --------------------------------------LGLRAPQWVRDKMVTMC----MRCQEP 470

  Fly  1983 RSSQNEVNRTMSIRSTG------EPI-----------QKYSANGTEANDVTLRHSQSTRESVRPG 2030
            .::.  ..|....|:.|      ||:           .||..|  ..|.|.|........:|.|.
Human   471 FNAL--TRRRHHCRACGYIFVPAEPVVCARCSDYRAELKYDDN--RPNRVCLHCYAFLTGNVLPE 531

  Fly  2031 STGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQ----------------SPLVDPTAIQ 2079
            :..::|...  :..|:|.....|::||         .:|                .|..||..:.
Human   532 AKEDKRRGI--LEKGSSATPDQSLMCS---------FLQLIGDKWGKSGPRGWCVIPRDDPLVLY 585

  Fly  2080 VSISP----AHTAEPVL 2092
            |..:|    |||:.|:|
Human   586 VYAAPQDMRAHTSIPLL 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	45/195 (23%)
		PH_RhoGEF	1770..1875	CDD:275411	22/108 (20%)
		DUF2413	2242..>2378	CDD:287302
FGD2	XP_016865918.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810