DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Plekhg6

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_941006.2	Gene:	Plekhg6 / 213522	MGIID:	2682298	Length:	787	Species:	Mus musculus

Alignment Length:	869	Identity:	187/869 - (21%)
Similarity:	298/869 - (34%)	Gaps:	250/869 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1398 PNDEQLDLGLSNA---TYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPH 1459
            ||:..|. ||..:   ||.|...:|..|..|:..|            .||..|.|.
Mouse     7 PNEGPLQ-GLVASRIETYGGRHQTSAHSTAGNLFP------------RGGPGVDPS--------- 49

  Fly  1460 LLIQQHAQQYCQQDSFQAGLAGAAGSS---------AASNSSFWNAGHP---------------- 1499
               ::..|.|.   .|..|.....|.|         ...:.|::..|.|
Mouse    50 ---RRRLQHYV---PFAKGSGQTRGMSPLVLREPDPEKRHGSYFGVGPPHSPKLKEVTRAHELEI 108

  Fly  1500 ------------LPV---ARWTL-ESEDEDDVNEADWSSMVAAEVLAALTDAEKKR-----QEII 1543
                        ||.   ..|.: |..|.....|..|..:|       |...|..|     ||.:
Mouse   109 RLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTMEKSWKELV-------LEHKEMNRQLCHQQEAL 166

  Fly  1544 NEIYQTERNHVRTLKLLDRLF---FLPLYESGLLSQDHLLLLF--PPALLSLREIHGAFEQSLKQ 1603
            .|:..||..::|.||::..|.   .|.|...|||::.....||  .|.|:   ..|..|.:.:.|
Mouse   167 WELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETLFGNVPNLI---RAHRRFWEEVLQ 228

  Fly  1604 RRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA------AQFCARQQIALEALKEKRNKDEMLQKL 1662
            ..:|.   ..|.|..| |....|:|.:  .|.      .|:|.|.:..:...:|:::.:.:....
Mouse   229 PILED---TRTSGQPL-DPVSLQNGFL--TFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHTF 287

  Fly  1663 LKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRIL 1727
            ::..|.||...|..|.|||....||:||||||.:.:.|.:    ||...: ||:...:|:.:..|
Mouse   288 VQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVRKRS----PEPRAQ-EALNAMIEAVESFL 347

  Fly  1728 VEVNQAVKTAEDAHKLQNIQRK------LDRSSYDKEE----FKKLDLT----------QHHLIH 1772
            ..:|..|:..|:...|..:.::      |:.||.:.|:    |..|||.          ...|:.
Mouse   348 RHINGQVRQGEEQESLMAVAQRIGPYEVLEPSSEEVEKNLRPFSTLDLMTPVLGVAPEYTRQLLL 412

  Fly  1773 DGNLTIK--KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQ 1835
            :|.:.:|  :...:.::..||.:::::...|......|.:..||.:             :.|:.:
Mouse   413 EGPVRVKEGREGKMDVYLFLFSDVLLVTKPQRKADRAKVIRPPLML-------------EKLVCR 464

  Fly  1836 EAADKNSFFLIKMK----TSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISD 1896
            ...|.|||.||.:.    .|..|.:..|||:|...|.:..........|.:.:...
Mouse   465 PLRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQTTLQKLKGEQYI--------- 520

  Fly  1897 PALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLR 1961
                    ...:|.|.|..:     ..|.:.:|.|..|       :|:|..:.|:....| ::..
Mouse   521 --------QQKRELLALYRN-----QGTESPSTRPSTP-------SPSPEDSQSSAEGRT-LEFA 564

  Fly  1962 NPQRDATASESDADYVNTP--------------KPRSSQNEVNRTMSIRSTGEPIQKYSANGTEA 2012
            ...|.....::|.|..:.|              .|:.|.:.:||..|.....:|...:|.  .|.
Mouse   565 IIPRLVVTEDTDEDTPSMPDDASDSGYGTLIPSSPKDSHSPLNRLRSKALRRDPRLTFST--LEL 627

  Fly  2013 NDVTLRHSQSTRESVRPGSTGEERNST----YGMVGGNSKRDSASIVCSNNSNNT--------RT 2065
            .||.||...       |.....:|.|.    .|::.|.|....|..:.|...:.|        .|
Mouse   628 RDVPLRPQP-------PDPQAPQRRSAPELPEGILRGGSLPRRAPPIWSEEEDETLASGNVVVET 685

  Fly  2066 L---LMQSPLVDPTAIQVSISPAHT-------------AEPVLTPGEKLRRLDASIRNDLLEKQK 2114
            |   ..:|||..        ||.||             .|.:|:|..:.|    |:|.|:|.:
Mouse   686 LHRAQRRSPLPH--------SPTHTDSAGESPWESSDEDEGLLSPELRPR----SLREDMLRE-- 736

  Fly  2115 IICDIFRLPVEHYDQIVDIAMMPE 2138
                   :..|..:|.:|.|..||
Mouse   737 -------IREELANQRIDGASEPE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	57/207 (28%)
		PH_RhoGEF	1770..1875	CDD:275411	23/110 (21%)
		DUF2413	2242..>2378	CDD:287302
Plekhg6	NP_941006.2	RhoGEF	165..351	CDD:366202	54/199 (27%)
		PH_PLEKHG5_G6	408..505	CDD:270064	23/109 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..762		56/259 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740