DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Arhgef11

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_006501327.1	Gene:	Arhgef11 / 213498	MGIID:	2441869	Length:	1579	Species:	Mus musculus

Alignment Length:	2242	Identity:	496/2242 - (22%)
Similarity:	776/2242 - (34%)	Gaps:	803/2242 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 QSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLALPKNFQYLTLTVRKDSN 268
            ||..|:|:.......|||..:...|.....|.|.|.|..||.......:          ::||.:
Mouse    17 QSHLSSPIASWLSSLSSLGDSTPERTSPSHHRQPSDTSETTGLVQRCVI----------IQKDQH 71

  Fly   269 GYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVK 333
            |:|..||||..|.|:||:|||||..||:..||.|::|||..|....|..||.|||:...|.|.:.
Mouse    72 GFGFTVSGDRIVLVQSVRPGGAAMRAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 136

  Fly   334 RSQKLTRPSSVSVV-TPSTPILSGRDRT----------------ASITGPQPVDSIKRREMETYK 381
            .|.    |||:.|. ....|.|||..|.                ..||||:|   ::..|::.:.
Mouse   137 GSS----PSSIGVSGLQQNPSLSGGPRVNPMIPPPPPPPPLPPPQHITGPKP---LQDPEVQKHA 194

  Fly   382 IQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKLREQLHQVGAEDAPTVKLQAAAGNKNTAL 446
            .|.|:.||.||:..|:|:                                     ....::|.|.
Mouse   195 TQILRNMLRQEEKELQRI-------------------------------------CEVYSRNPAS 222

  Fly   447 LTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSLLPRSLSSLSLGTRKN 511
            |...||:                                                     |.|:.
Mouse   223 LLEEQIE-----------------------------------------------------GARRR 234

  Fly   512 KTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETGPTSK 576
            .|:..|......|...|.|..                                      .|.||
Mouse   235 VTQLQLKIQQETGGLVDVLPL--------------------------------------CGETS- 260

  Fly   577 GKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQ 641
                                 ||....:|::|.:..::.
Mouse   261 ---------------------QRTCEGRLSVDSQEADSG-------------------------- 278

  Fly   642 QQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQMESASAAGAAGGSIEVDGGPPPLPPRL 706
              |.|.|:..||.::|..:  :...||||.:.:
Mouse   279 --LDSGTERFPSISESLVN--RNSVLSDPGLDS-------------------------------- 307

  Fly   707 PGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQ 771
                                        |..|                   |.|:.::.|:
Mouse   308 ----------------------------PQTS-------------------PVILARVGQH---- 321

  Fly   772 QHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTP 836
                                   |||.||.. .:||.:...|.::
Mouse   322 -----------------------HRRQGSDA-AVHPLNHQGIDQS-------------------- 342

  Fly   837 PPPYLSSSHMTVLEDPNENNRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQ 901
            |.|        ::..|.|:      ..||.|                               :.:
Mouse   343 PKP--------LIIGPEED------YDPGYF-------------------------------NNE 362

  Fly   902 KEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYK 966
            .:||                   |.:|.:|  ..:..:|.:||.|:.|.:||.||||||.:|:|:
Mouse   363 SDII-------------------FQDLEKL--KSHPAYLVVFLRYIFSQADPGPLLFYLCSEVYQ 406

  Fly   967 EGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKD 1031
            :...||.|....:|.:.||...|||. .:..|.|..|:|..|:...|.    |:....:::....
Mouse   407 QTNPKDSRNLGKDIWNIFLEKNAPLR-VKIPEMLQAEIDLRLRNSEDP----RSALYEAQEAVMP 466

  Fly  1032 LISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLREQ------------IIDKYLMPNLHALI 1084
            .|.||:.:::.|||.|||::||..|  |.:...|.|||:            |:.||
Mouse   467 EIQEQINDYRSKRTLGLGSLYGEND--LLDLDGDPLRERQMAEKQLAALGDILSKY--------- 520

  Fly  1085 EDENGSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVR 1149
             :|:.|.|.|   .|:.:.:|....|:..:|  |||..|:......:||
Mouse   521 -EEDRSAPMD---FAVNTYMSHTGIRLRESR--PSSTAEKTQSAPDKDK---------------- 563

  Fly  1150 GHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHND 1214
                                  |                           .|. .|:.|:.:.|.
Mouse   564 ----------------------W---------------------------LPF-FPKTKKQSSNS 578

  Fly  1215 KISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSC 1279
            |..|          |.:.::||                               |..:|..|....
Mouse   579 KKEK----------DALEDKKR-------------------------------NPILRYIGKPKS 602

  Fly  1280 NTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDT 1344
            ::        ||:||...:...:.||...........|.....|. .|:......:|.|    |.
Mouse   603 SS--------QSTFHIPLSPVEVKPGNVRNIIQHFENSHQYDVPE-PGTQRLSTGSFPE----DL 654

  Fly  1345 VDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNR---NSRRKTSDPSLSSRPNDEQLDLG 1406
            ::.::.|           :.:.:.||||.|.|...||:|   |..|..||..:.:.....:|...
Mouse   655 LESDSSR-----------SEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQS 708

  Fly  1407 LSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQ 1471
            .|      ||.||||        :.|:|:...|      ..|.||....:.|:|       .:|.
Mouse   709 AS------SSASSLS--------TRSLENPTPP------FTPKMGRRSIESPNL-------GFCT 746

  Fly  1472 QDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAE 1536
            .......|....|..:                    :.|.|.:|.  :|...|..:|:|.||..|
Mouse   747 DVILPHLLEDDLGQLS--------------------DLEPEPEVQ--NWQHTVGKDVVANLTQRE 789

  Fly  1537 KKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFP--PALLSLREIHGAFEQ 1599
            ..|||:|||::.||.:|:|||::||.:|:..:.:..|:.::.|..|||  |.|:   |||.::.:
Mouse   790 IDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELSRLFPNLPELI---EIHNSWCE 851

  Fly  1600 SLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLK 1664
            ::|:.| |...::..|.||:...|||.:...|.:.|||||:.|.:|||.::.|:.|:...|..::
Mouse   852 AMKKLR-EEGPIIRDISDLMLARFDGPAREELQQVAAQFCSYQSVALELIRTKQRKESRFQLFMQ 915

  Fly  1665 KSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVE 1729
            ::|||..||||:|:||:.:.:|||||||||.||:.|.|.    ..|:|.|.:.||.:..:.||..
Mouse   916 EAESHPQCRRLQLRDLIISEMQRLTKYPLLLENIIKHTA----GGTSEYEKLCRARDQCREILKF 976

  Fly  1730 VNQAVKTAEDAHKLQNIQRKLDRSSYDK------EEFKKLDLTQHHLIHDGNLT--IKKNPSVQL 1786
            ||:|||..|:.|:|:..|::||.::.::      .|||.||||...:||:|.||  |.|:.::.|
Mouse   977 VNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDL 1041

  Fly  1787 HGLLFENMIVLLTKQDDKYYLKNLHTPLSI----TNKPVSPIMSIDADTLIRQEAADKNSFFLI- 1846
            ..||.|:::|||.:|::|..|| .|:..::    :.:..||::.::| .|||..|.||.:||:|
Mouse  1042 QVLLLEDLVVLLQRQEEKLLLK-CHSKTAVGSSDSKQTFSPVLKLNA-VLIRSVATDKRAFFIIC 1104

  Fly  1847 --KMKTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDT--SISDPALAAIPHSNT 1907
              ::...|:.||.|.:||:...|.:...:.....:|:.......||.:  ...:||.    ..:|
Mouse  1105 TSELGPPQIYELVALTSSDKNIWMELLEEAVQNATKHPGDAPVLNHPSPPGSQEPAY----QGST 1165

  Fly  1908 KESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASES 1972
            ...:|::...|.|         |...|..|  :..|.|.....:...|.   ...|:::..|.|.
Mouse  1166 SSRVEVNDSEVYP---------TEREPKKP--SEGPGPEQRGQDKQLLA---QEGPEQEEDAEEL 1216

  Fly  1973 DADYVNTPKPRSSQNEVNRTMSIRS------TGEPIQKYSANGTEANDVTLRHSQSTRESVRPGS 2031
            .|    .|.|..|.:..||.:..|.      ||..:.:..|:....:...|||  ....|:.||.
Mouse  1217 RA----LPCPPPSLDGENRGIRTRDPVLLALTGPLLMEGLADAALEDVENLRH--LILWSLLPGH 1275

  Fly  2032 TGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGE 2096
            |.:.:      ..|..:.|                      :.||...|||: :|..:|. :||:
Mouse  1276 TVKTQ------AAGEPEDD----------------------LTPTPSVVSIT-SHPWDPG-SPGQ 1310

  Fly  2097 --------------------------KLRRLDASIRNDLLEKQKIICDIFRLPVEH--------- 2126
                                      .|..|....||..:....   ::.|.|.|.
Mouse  1311 APAISDNTQFPRPEGSQPEGEDVALCSLAHLPPRTRNSGIWDSP---ELDRNPAEEASSSEPAGS 1372

  Fly  2127 YDQIVDIAMMPEAPKDSADIALAAYDQIQTLTKMLNEYMHVTP--------EQEVSAV--STAVC 2181
            |..:..::::|.....:|.:|.:                :|||        |.|:|.|  .....
Mouse  1373 YKVVRKVSLLPGGGVGAAKVAGS----------------NVTPALPESGQSESELSEVEGGAQAT 1421

  Fly  2182 GHCHEKEKLRKKVAPSSSFSSSPPPLPPPNRQ-HA-QAQAQIPP----------SRLMPK----- 2229
            |:|.   .:.....|..| |:.||..||...| |: .|....||          |.|:.:
Mouse  1422 GNCF---YVSMPAEPLDS-STEPPGTPPSLSQCHSLPAWPTEPPQHRGVTGGQRSSLVLRDMGVI 1482

  Fly  2230 LQTLDLDEVAIHEDDDGYCEIDELRLPAIPSKPHERPTTPLAPFNTEPK--TSQSVIDASKRQST 2292
            ..|::...|.:|...|  .|:....|...........|||:..|:||..  |..|:...:|...|
Mouse  1483 FHTIEQLTVKLHRLKD--MELAHRELLNSLGGESSGGTTPVGSFHTEAARWTDYSLSPPAKEALT 1545

  Fly  2293 DAVPEGLLEQEPLEGDKTETKGEDNEVKTVPS 2324
             :.|:...||.....:.::|..||:...|..|
Mouse  1546 -SDPQNNQEQGSYPEEGSDTPLEDSATDTASS 1576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570	34/73 (47%)
		RGS_GEF_like	934..1055	CDD:188710	42/120 (35%)
		C1_1	1151..1202	CDD:278556	1/50 (2%)
		RhoGEF	1539..1731	CDD:238091	77/193 (40%)
		PH_RhoGEF	1770..1875	CDD:275411	38/113 (34%)
		DUF2413	2242..>2378	CDD:287302	21/85 (25%)
Arhgef11	XP_006501327.1	PDZ_signaling	62..136	CDD:238492	34/83 (41%)
		RGS_PDZRhoGEF	346..490	CDD:188707	52/206 (25%)
		RhoGEF	795..978	CDD:366202	74/190 (39%)
		PH_PRG	996..1138	CDD:275426	47/143 (33%)
		PHA03247	<1127..1469	CDD:223021	79/418 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4815
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2447
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001574
OrthoInspector	1	1.000	-	-		otm43948
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3275
SonicParanoid	1	1.000	-	-		X2399
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.950