DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF2 and prhg-1

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	NP_001122556.1	Gene:	prhg-1 / 190810	WormBaseID:	WBGene00022391	Length:	628	Species:	Caenorhabditis elegans

Alignment Length:	767	Identity:	152/767 - (19%)
Similarity:	271/767 - (35%)	Gaps:	244/767 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1328 SVAAGLSAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKR-----NRNSRR 1387
            |.|..|:.|..:.....:......|..:.||.              ||:||.:.     ..:..:
Worm     3 SEAPALTLFHHIRGNQLIKPPEEGEPQTIHPN--------------KEQLSRRHAIIPDQPSENQ 53

  Fly  1388 KTSD------------PSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPS---TSMEHFA 1437
            :||.            |.:...||:..|            .|.::||.||..:.|   ||::...
Worm    54 ETSSQGCCSSDNVIIVPHVQISPNESHL------------FNRAISSGGGLLADSNKITSIDLQR 106

  Fly  1438 APGAAGGVQVPPMGLNQNQHPHLL--------------IQQHAQQYCQQDSFQAGLAGAAGSSAA 1488
            |..|:...........:|:.|.:|              |.:|.|                   ||
Worm   107 ATIASQAFYAEASEPQKNRSPWILKRLYEWSGRAKRREIIKHVQ-------------------AA 152

  Fly  1489 SNSSFWNAGHPLPVARWTLESEDEDDVNE----ADWSSMVAAEVLAALTDAEKKRQEIINEIYQT 1549
            ..:|              .:.|.|||..|    ..:..|...:....:..::.|..:.:.|::.|
Worm   153 LETS--------------KDHEIEDDELEKLLPVSFEEMFMGDETTTIPSSKHKYLQAVWELFHT 203

  Fly  1550 ERNHVRTLKLLDRLFFL-PLYESGL--LSQDHLLLLFPPALL-----SLREIHGAFEQSLKQRRI 1606
            |     .:.|..:||.| .:|:..|  ...:..|||..|.||     .|..|...|.||...
Worm   204 E-----LVFLYRQLFVLRDVYKEPLKRCQVEGCLLLVEPDLLFGNLDQLCRISRTFCQSFLS--- 260

  Fly  1607 EHNHVVNTIG-------DLLADMFD----GQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQ 1660
                :::|:.       .|:.|:|:    |.|.:...:   .:|...:..:|.|...|.|:|...
Worm   261 ----LLSTVDKENWDCTQLVVDLFERFSKGPSTISAYQ---AYCINYKATMEYLGSIRQKEERFT 318

  Fly  1661 KLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEA---IQRAVES 1722
            :..:...:.:.|.||:|:|||...|||:|:.|:|...::|        .:.|.|:   :::.:::
Worm   319 EFERICLADERCFRLQLEDLLIAPLQRITRLPILLREIHK--------RSEEEESKGKVEKVIDT 375

  Fly  1723 SKRILVEVNQAVKTAEDAHKLQNIQRK--------LDRSSYDKEEFKKLDLT-----------QH 1768
            ....|..::.:|:...:..:||.:|.:        |:..|| ..:|.::.|:           :.
Worm   376 MTESLRSIDDSVQWLHNFERLQQLQTQVVWPNISDLEPKSY-VPDFLRVALSRQFCENLLAHPRR 439

  Fly  1769 HLIHDGNLTIKKN-PSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLS------ITNKPVSPIMS 1826
            .|||:|.|.:.:| .:|.::..||.:|.||...:.....||....|:.      :..:|| |:.|
Worm   440 KLIHEGPLELVENGRTVDMYAFLFNDMFVLTKTKKCASKLKVKGVPIGKSEHYIVQRQPV-PLDS 503

  Fly  1827 ---IDADTLIRQEAAD---KNSFFLIKM----KTSQMLELRAPSSSECKTWFKHFSDVAARQSKN 1881
               .|||:  ..:|..   |.:|.:|.:    :...:..|:|...::.:.|.:.|.:
Worm   504 CVFCDADS--NDQATPMSLKFAFVIIHLTRYYQVVGIYTLQAADKADKELWIEKFQE-------- 558

  Fly  1882 RSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPA 1946
                       ||.:           .||::|..          .|..|||
Worm   559 -----------SIEN-----------YESIQLKD----------MLKCTPL-------------- 577

  Fly  1947 TNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRST 1998
                 .|||:   ||........|:|:::....||.:..:.|..:.....||
Worm   578 -----FSSLS---LRRCSSSRLMSKSESNSPQLPKEKEKEKEEKKECCSSST 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556
		RhoGEF	1539..1731	CDD:238091	49/213 (23%)
		PH_RhoGEF	1770..1875	CDD:275411	30/121 (25%)
		DUF2413	2242..>2378	CDD:287302
prhg-1	NP_001122556.1	RhoGEF	196..385	CDD:279015	49/211 (23%)
		PH_PLEKHG7	440..557	CDD:270065	29/119 (24%)
		PH	441..561	CDD:278594	31/141 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45872
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010