DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and tag-52

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_508633.1 Gene:tag-52 / 180657 WormBaseID:WBGene00006431 Length:665 Species:Caenorhabditis elegans


Alignment Length:765 Identity:130/765 - (16%)
Similarity:247/765 - (32%) Gaps:272/765 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1541 EIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRR 1605
            :|:.|||.|||.:|:.|.::|.:|.           ..|.|..|.:....|.:.|          
 Worm    57 QILQEIYDTERTYVKALTIVDEIFI-----------QQLNLWCPKSKKCFRSMFG---------- 100

  Fly  1606 IEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEK------------------ 1652
                                       |.:| .|...||.||:|:.|                  
 Worm   101 ---------------------------EISA-ICKTHQILLESLQCKPIAEVFTKFVPFLKLYTS 137

  Fly  1653 -----RNKDEMLQKLLKKSESHKACRRLE---------LKDLLPTVLQRLTKYPLLFENLYKVTV 1703
                 .|..::..||:.:::..||..::|         |:..|...:||:.:|.:|.:||...  
 Worm   138 YASHYPNSLKIFAKLMSRNDFRKALTKIEEDPRVDGKKLQTYLIMPIQRIPRYIMLIQNLMNY-- 200

  Fly  1704 RLLPENTTEAE---AIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKEEFKKLDL 1765
                  :||.:   .:.:|:...:.:..::...:...|:..:|..||....           || 
 Worm   201 ------STEKDDMTNLYKALSGMQGLSDQIQSCMTAYENGERLLQIQLNFG-----------LD- 247

  Fly  1766 TQHHLIHDGNLTIKKNP--SVQLHGLL-FENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSI 1827
              .|::..|.:.:|:..  ..:|:|.. ::..:|.|......|.:|.:         .|.|    
 Worm   248 --GHILEPGRVLLKEGMLYKRELNGSANYQETVVFLFNDILLYGIKRI---------SVMP---- 297

  Fly  1828 DADTLIRQEAADKNSFFLIKMKTSQMLELR-------------------------APSSSECKTW 1867
                             |.|.:.|.:|.||                         |.|......|
 Worm   298 -----------------LCKYEPSAILSLRHCIVQLDDIGGSIFIRCGDVGVDFTAYSLGGVTEW 345

  Fly  1868 FKHFSDVA--ARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTT 1930
            :....|..  |::.::..:..|....:.|.|           |...:.:.|.::.: .||.:|..
 Worm   346 YNEICDAIDNAKKLRDTLRKESFKQKSLIFD-----------KGFWQRNRDKLRNM-ITADMTGN 398

  Fly  1931 PLAPMLPIATV----TPAPATNNSN-------VSSLTGVQLRNPQRDATASESDADYVNTPKPRS 1984
                   |:.|    .|||....|:       .|::...|.:  ::.||..:.:.|..|.   .|
 Worm   399 -------ISRVLTRKKPAPKLEESDFLRGQWTTSTIASNQRK--RKVATLEDEEEDVFNM---LS 451

  Fly  1985 SQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQSTRESVRPGSTGEERNSTYGMVGGNSKR 2049
            |.|     :|.|.....:|:.:.:|.                   |.|...|:|::.....::.|
 Worm   452 SPN-----LSQRKRKATLQENTPSGV-------------------GWTASPRSSSFRKRRASTLR 492

  Fly  2050 DSASIVCSNNSNNTRTLLMQSPLVDP-TAIQVSISPAHTAEPVLTPGEKLRRLDASIRND----L 2109
            :..:.|...|:..:..:|....:..| |.:...:....:..|.          |....:|    .
 Worm   493 NKNADVTDGNNYLSHLVLNDVTMTQPYTGLNAFVGTPKSRTPT----------DDDYDSDRDYVW 547

  Fly  2110 LEKQKIICDIFRLPVEH---YDQIVDIAMMPEAPKDSADIALA----------AYDQIQTLT--- 2158
            .:.::.:.|..::|:..   ||:      ....|:|.:::..:          |.|.|:.|:   
 Worm   548 TDDEEFVSDDKKIPIRRVASYDE------EDRRPRDFSEVRRSVASEPPRRHLAVDDIRKLSYQQ 606

  Fly  2159 KMLNEYMHVT-PEQEVSAVSTAVCGHCHEKEKLRKKVAPSSSFSSSPPPL 2207
            :.|..:..|| .:.|...:...|.|         ::..|.....|:||.:
 Worm   607 RSLEPFNMVTEDDDEDDIIDIKVKG---------ERPRPWWETESAPPAI 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 42/224 (19%)
PH_RhoGEF 1770..1875 CDD:275411 20/132 (15%)
DUF2413 2242..>2378 CDD:287302
tag-52NP_508633.1 RhoGEF 58..224 CDD:279015 42/222 (19%)
PH-like 232..>318 CDD:302622 23/129 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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