| Sequence 1: | NP_477317.1 | Gene: | RhoGEF2 / 36915 | FlyBaseID: | FBgn0023172 | Length: | 2559 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_006539628.1 | Gene: | Arhgef1 / 16801 | MGIID: | 1353510 | Length: | 980 | Species: | Mus musculus |
| Alignment Length: | 1276 | Identity: | 305/1276 - (23%) |
|---|---|---|---|
| Similarity: | 490/1276 - (38%) | Gaps: | 393/1276 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 858 GAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDEN--SDLDEPFID 920
Fly 921 ENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHSTFL 985
Fly 986 ----VPRAPLSWYRQDESLAREVDNV---LQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQK 1043
Fly 1044 RTAGLGTIYGPTDDKLA-------------EAKTDKLREQIIDKYLMPNLHALIEDENGSPPEDV 1095
Fly 1096 RKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKS---------FKSRIMGKNR------- 1144
Fly 1145 -----------KMNVRGHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDE 1198
Fly 1199 SCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDR 1263
Fly 1264 RPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGS 1328
Fly 1329 VAAGLSAFAELNALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPS 1393
Fly 1394 LSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHP 1458
Fly 1459 HLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSM 1523
Fly 1524 VAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALL 1588
Fly 1589 SLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKR 1653
Fly 1654 NKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQR 1718
Fly 1719 AVESSKRILVEVNQAVKTAEDAHKLQNIQRKLD----RSSYDK--EEFKKLDLTQHHLIHDGNLT 1777
Fly 1778 --IKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLH----TPLSITNKPVSPIMSIDADTLIRQE 1836
Fly 1837 AADKNSFFLIKM--KTSQMLELRAPSSSECKTWFKHFSDVA------ARQSKNRSKNASSNHDTS 1893
Fly 1894 ISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAP-----ATNNSNVS 1953
Fly 1954 SLTGVQLRNPQRDATASESDADYV---NTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDV 2015
Fly 2016 TLRHSQSTRE--------------SVRPGSTGEERNSTYGM 2042 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| RhoGEF2 | NP_477317.1 | PDZ | 260..334 | CDD:214570 | |
| RGS_GEF_like | 934..1055 | CDD:188710 | 31/127 (24%) | ||
| C1_1 | 1151..1202 | CDD:278556 | 5/50 (10%) | ||
| RhoGEF | 1539..1731 | CDD:238091 | 76/191 (40%) | ||
| PH_RhoGEF | 1770..1875 | CDD:275411 | 33/112 (29%) | ||
| DUF2413 | 2242..>2378 | CDD:287302 | |||
| Arhgef1 | XP_006539628.1 | RGS_p115RhoGEF | 50..242 | CDD:188709 | 48/231 (21%) |
| PHA03247 | <277..462 | CDD:223021 | 59/372 (16%) | ||
| RhoGEF | 479..663 | CDD:214619 | 74/189 (39%) | ||
| PH_p115RhoGEF | 697..821 | CDD:275429 | 39/125 (31%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C167836645 | |
| Domainoid | 1 | 1.000 | 138 | 1.000 | Domainoid score | I4815 |
| eggNOG | 1 | 0.900 | - | - | E1_COG5422 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 327 | 1.000 | Inparanoid score | I2447 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S6267 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D163264at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001574 | |
| OrthoInspector | 1 | 1.000 | - | - | otm43948 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR45872 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3275 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 12 | 11.840 | |||||