DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF2 and Arhgef2

DIOPT Version :9

Sequence 1:	NP_477317.1	Gene:	RhoGEF2 / 36915	FlyBaseID:	FBgn0023172	Length:	2559	Species:	Drosophila melanogaster
Sequence 2:	XP_006501121.1	Gene:	Arhgef2 / 16800	MGIID:	103264	Length:	1185	Species:	Mus musculus

Alignment Length:	1339	Identity:	279/1339 - (20%)
Similarity:	474/1339 - (35%)	Gaps:	384/1339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1194 KVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVR 1258
            ::....|||           .:.:.|:     ::.:.:|....::|.|:       .:||.....
Mouse    91 RLQSSECPG-----------SQEAPFL-----QSLEELGTPLGAQQQEQ-------QQGQEQQRG 132

  Fly  1259 QPSDR-----RPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGG---------AG 1309
            ||..|     .|.|..|:.|  .|...:..::.:|:      :..:|..:|.|.         :.
Mouse   133 QPFHRGQSFCYPSAASSVPS--VTGMLSKAVSMSDI------NLLSDCSDPNGNSPQSYVTDLSK 189

  Fly  1310 CNMDL---STSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQHPKHKSAPVSV---- 1367
            |...|   |.:.|.::...:.|...|::...:....:.: |||:..||:.  .|....:||
Mouse   190 CGKQLEEDSGTWAGSSLRRTFSFLLGMTGRDKTREKEKM-KEAKDARYTN--GHLFTTISVSGMT 251

  Fly  1368 -----NRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGLSNATYVGS---------SNS 1418
                 |:|.:.||.|.        ..|.:.::.:|..|.     |:|.|.|..         :|:
Mouse   252 MCYACNKSITAKEALI--------CPTCNVTIHNRCKDT-----LANCTKVKQKQQKAALLRNNT 303

  Fly  1419 SLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGA- 1482
            :|.|. ...|.:|:.|.   |.:|    :.|                      .|||:..|.|:
Mouse   304 ALQSV-SLRSKTTTRER---PTSA----IYP----------------------SDSFRQSLLGSR 338

  Fly  1483 ---AGSSAASNSSFWN-AGH------------------PLPVARWTLESE--------------- 1510
               :..|.|.:.|..| |||                  .|.:...||..|
Mouse   339 RGLSSLSLAKSVSTTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELM 403

  Fly  1511 -----DEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYE 1570
                 ||.|.....||..|.:..|........|:|::|.|:.|||.:||||||::.|||...:.|
Mouse   404 SDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLE 468

  Fly  1571 SGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIE-------HNHVVNTIGDLLADMFDGQSG 1628
            ...:..:.:..|| |.:..|.:||..|...|.:||.:       .|.|::.:||||...|.|.:.
Mouse   469 ELQMEPEVVQGLF-PCVDELSDIHTRFLNQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNA 532

  Fly  1629 VVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPL 1693
            ..:.:..::||:|...||:..||...:|:..|:.::|.......:|..:::.:..|.||:||||:
Mouse   533 EQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPV 597

  Fly  1694 LFENLYKVTVRLLPEN---TTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSY 1755
            |..       |:|..:   ..|.:.:..|:...|.:|..|:|.|...|...:||.|..::|..:.
Mouse   598 LIN-------RILQNSHGVEEEYQDLASALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQ 655

  Fly  1756 ----DKEEFKKLDLTQHHLIHDGNLTIK----KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHT 1812
                .|..|.:.:|.:..|||:|.|..|    :...|.|  ||..:::|.|.::|.||...:|..
Mouse   656 TPVPGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLL--LLMTDVLVFLQEKDQKYIFTSLDK 718

  Fly  1813 PLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHF------ 1871
            |         .::|:. :.::|..|......|||.....:|.|:.|.|..:..||.:..
Mouse   719 P---------SVVSLQ-NLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRL 773

  Fly  1872 ----SDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPL 1932
                .|....::::::............:.||..:...|    :||..:.|...|..|.....|
Mouse   774 CPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQKN----VELFAEMVHFQALKAGFVGMP- 833

  Fly  1933 APMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATAS-ESDADYVNTPKPRSSQNEVNRTMSIR 1996
            .|.||....      ...:..||.|.:|   .:||... |...|.:..|.       |:..|:.|
Mouse   834 PPALPRGLF------RLESFESLRGERL---LKDALREVEGLKDLLLGPC-------VDLPMTSR 882

  Fly  1997 STGEPIQKYSAN--GTEANDVTLRHSQSTRESVRPGSTGEER--NSTYGMVGGNSKRDSASIVCS 2057
            ....|:...|.:  |..||                   ||.|  |.:..:    .:.||.|....
Mouse   883 EPALPLDSDSGSCPGVTAN-------------------GEARTFNGSIEL----CRADSDSSQKD 924

  Fly  2058 NNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKIICDIFRL 2122
            .|.|..|                  ||   .|.||.|...|..|...::..::::::::
Mouse   925 RNGNQLR------------------SP---QEEVLQPLINLYGLLHGLQAVVVQQERLM------ 962

  Fly  2123 PVEHYDQIVDIAMMPEAPK-------------DSADIALAAYDQIQTLTKMLNEYMHVTPEQEVS 2174
                      .|:.||.|:             ::...|:|:                ||||::.:
Mouse   963 ----------EALFPEGPERWEKLSRANSRDGEAGRAAVAS----------------VTPEKQAT 1001

  Fly  2175 AVSTAVCGHCHEKEKLRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQI--PPSRLMPKLQTLDLDE 2237
            .::.....|...:|:||:........::....|....|:..||:|.:  ....:..:|..|..:|
Mouse  1002 ELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNE 1066

  Fly  2238 VAIHEDDDGYCEIDELR--LPA-----------IPSKPHERPTTPLAPFNTEPKTSQSVIDASKR 2289
            ....|.......:|..|  |||           .||:.|:|...|:        |.:|:
Mouse  1067 PLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPV--------TVRSL------ 1117

  Fly  2290 QSTDAVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKN 2354
                        ..|.:..:.:..|.       |.|:|.:|                :||.|...
Mouse  1118 ------------HRPFDDREAQELGS-------PEDRLQDS----------------SDPDTGSE 1147

  Fly  2355 EAAASVDELPSQSREIKTAENASKSVADKKEDNEETIEE 2393
            |..:|....|...|:....::..:..  :..|.|.|..|
Mouse  1148 EEVSSRLSPPHSPRDFTRMQDIPEET--ESRDGEPTASE 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ	260..334	CDD:214570
		RGS_GEF_like	934..1055	CDD:188710
		C1_1	1151..1202	CDD:278556	1/7 (14%)
		RhoGEF	1539..1731	CDD:238091	59/201 (29%)
		PH_RhoGEF	1770..1875	CDD:275411	30/118 (25%)
		DUF2413	2242..>2378	CDD:287302	26/148 (18%)
Arhgef2	XP_006501121.1	C1	240..285	CDD:237996	12/57 (21%)
		RhoGEF	437..631	CDD:238091	59/201 (29%)
		PH_ARHGEF2	671..786	CDD:275428	30/126 (24%)
		TIGR02680	<1000..>1072	CDD:274256	12/71 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740