DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and Itsn1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_006522994.1 Gene:Itsn1 / 16443 MGIID:1338069 Length:1743 Species:Mus musculus


Alignment Length:1980 Identity:359/1980 - (18%)
Similarity:628/1980 - (31%) Gaps:672/1980 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 PGATSAGPSAG----APQSPVIVVDSVP--ELPAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLA 116
            |.|.|:.|:.|    |...|:..|..||  .:|.                       :..||.|.
Mouse   130 PVAISSAPAFGIGGIASMPPLTAVAPVPMGSIPV-----------------------VGMSPPLV 171

  Fly   117 SSLSSLA-SSLSGHRDRDKDRDKDRENQNAVPPQTPPLP------------PSYKQ----NQMNG 164
            ||:...| ..|:                |..||...|||            .|:.:    :|:|.
Mouse   172 SSVPPAAVPPLA----------------NGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNT 220

  Fly   165 DSTAAAGGGV-SAP-----ATPTTAN-------NNNASHNNGSIMGGGVQLNQSDNSNPVLQAPG 216
            ....|....| |||     |.|.::.       |::....:|.:.|...:.....:|.|..|.  
Mouse   221 KLQKAQSFDVASAPPAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQL-- 283

  Fly   217 ERSSLNLTPLSRDLSGGHTQE---------STTPATTPSTPSLALPKNFQYLTLTVRKDSNGYGM 272
             .|..||:.:.:|  |..|.|         ....:..|..|  .||.  :|:..:.|:..:|.||
Mouse   284 -ASIWNLSDIDQD--GKLTAEEFILAMHLIDVAMSGQPLPP--VLPP--EYIPPSFRRVRSGSGM 341

  Fly   273 KVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAV----K 333
            .|...:.|                            :.||.:.|:...  :.....:|.|    |
Mouse   342 SVISSSSV----------------------------DQRLPEEPSSED--EQQPEKKLPVTFEDK 376

  Fly   334 RSQKLTRPSSVSVVTPSTPIL----SGRDRTASI-TGPQPVDSIKRREMETYKIQTLQKMLEQEK 393
            :.:...| .||.:......:|    ..::|.|.: ...|.....:|:|.|..:...|:|.||:::
Mouse   377 KRENFER-GSVELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQR 440

  Fly   394 LNLERLKSDQNNPSYKLSEANIRKLREQ-------------LHQVGAEDAPTVKLQA-------- 437
             .|||.:.::.....:..||..|:|..|             |:|...|...||.|:|        
Mouse   441 -ELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEGTVVLKARRKTLEFE 504

  Fly   438 --AAGNKNTALLTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLS-LLPR 499
              |..:|...|  ..::|.:........|:....:....|........||....|...|. |:|.
Mouse   505 LEALNDKKHQL--EGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPE 567

  Fly   500 S--LSSLSLGTRKNKTEKDLTTSSPFGLTTDFLQQQRMSHQ---AESMSQSMHQHTSTPTSQ--- 556
            .  ||......::|...:|...:....|....|.:|::..|   .|..::|..|......:|   
Mouse   568 KQILSDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVERETRSKLQEIDVFNNQLKE 632

  Fly   557 -QFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRNPPRQ-LNLDLKNGNASPGGS 619
             :..|..||..:                .|||    ....|.|:...|: |.|:.:..:|.    
Mouse   633 LREIHSKQQLQK----------------QRSL----EAARLKQKEQERKSLELEKQKEDAQ---- 673

  Fly   620 HLVAPVSDLDRATSPQLNRSQQQQLPSSTDNSPSNAKSKRSKIKTKALSD---PKM---STQMFL 678
               ..|.:.|:   ..|...||::.|........:...:...::.|...:   |:|   .:::|.
Mouse   674 ---RRVQERDK---QWLEHVQQEEQPRPRKPHEEDRLKREDSVRKKEAEERAKPEMQDKQSRLFH 732

  Fly   679 QMESASAAGAAGGSIEVDGGPPPLPPRLPGMMTEDMSRGSCQNLAQPNSVGTAFN---YPLVSTT 740
            ..:.                |..|..:.|...||   :|.....|| .||...:.   ||..|.:
Mouse   733 PHQE----------------PAKLATQAPWSTTE---KGPLTISAQ-ESVKVVYYRALYPFESRS 777

  Fly   741 TAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQQ---HQMSGGQATGALGQTPNLGKNKHRRVGSSP 802
                :|.:.|     |..:||....::..:.|   ....||:..|..|..|   .|...::   |
Mouse   778 ----HDEITI-----QPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFP---ANYAEKI---P 827

  Fly   803 DNMHPRHPDRITKTTSG---SWEIVEKDG----ESSPPGTPP-------PPYLSSSHMTVLEDPN 853
            :|..|.....:|..||.   ...:.|...    .||.|.|.|       ..:.|||:    |.|.
Mouse   828 ENEVPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSSN----EKPE 888

  Fly   854 ENNRGAAAAGPGVFIES-------HQFTP-MAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDE 910
            .:|....||.|.:.:.|       ..||| .|..|||.|:......:...|:....         
Mouse   889 TDNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALY--------- 944

  Fly   911 NSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRK 975
                         |:.     .:.:|      .||:  :.||       :||.|.::    || .
Mouse   945 -------------PWR-----AKKDN------HLNF--NKSD-------VITVLEQQ----DM-W 971

  Fly   976 WAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKDLISEQLREF 1040
            |..|:       :....|:.:              .|.|                 |||..:|  
Mouse   972 WFGEV-------QGQKGWFPK--------------SYVK-----------------LISGPVR-- 996

  Fly  1041 QQKRTAGLGTIYGPTDDKLAEAKTDKLREQIIDKYLMPNLHALIEDENGSPPEDVRKVALCSALS 1105
               ::..:.|  |||:.                                  |..:::||..:|  
Mouse   997 ---KSTSIDT--GPTES----------------------------------PASLKRVASPAA-- 1020

  Fly  1106 TVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTI 1170
                                                   |..:.|...:....||          
Mouse  1021 ---------------------------------------KPAIPGEEFIAMYTYE---------- 1036

  Fly  1171 IWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEK 1235
               .|.||                                                         
Mouse  1037 ---SSEQG--------------------------------------------------------- 1041

  Fly  1236 RSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCAND 1300
                      :||..:|...:|             .:.:|:....|.|..:....|::       
Mouse  1042 ----------DLTFQQGDVIVV-------------TKKDGDWWTGTVGDKSGVFPSNY------- 1076

  Fly  1301 SINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQHPKHKSAPV 1365
                       :.|..|..|.|...:||:.                           .|.:.|.|
Mouse  1077 -----------VRLKDSEGSGTAGKTGSLG---------------------------KKPEIAQV 1103

  Fly  1366 SVNRSESYKERLSNKRNRNSRRKTSDP------SLSSRPNDEQLDLGLSNATYVGSSNSSLSSAG 1424
            ..:.:.:..|:|:....:....:..:|      .|.:|....|  :|...|.||...:...|...
Mouse  1104 IASYAATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQ--IGWFPANYVKLLSPGTSKIT 1166

  Fly  1425 GSESPSTSMEHFAAPGAAGGVQV--------PPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAG 1481
            .:|.|.|:::    |.....:.:        ..:..::.|..::|.::....:..:.|.|.||  
Mouse  1167 PTELPKTAVQ----PAVCQVIGMYDYTAQNDDELAFSKGQIINVLNKEDPDWWKGEVSGQVGL-- 1225

  Fly  1482 AAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEI 1546
                            .|....:.|.:.:...     .|.|.:  .:|..||..|:|||..|:|:
Mouse  1226 ----------------FPSNYVKLTTDMDPSQ-----QWCSDL--HLLDMLTPTERKRQGYIHEL 1267

  Fly  1547 YQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIE---- 1607
            ..||.|:|..|:|:..:|..||.||.||::..:.::|    ::.:|:.....:.||..|:.    
Mouse  1268 IVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIF----VNWKELIMCNIKLLKALRVRKKMS 1328

  Fly  1608 -HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKA 1671
             ....|..|||:|:.........:      :||:.|......:::|.::....::.:|:......
Mouse  1329 GEKMPVKMIGDILSAQLPHMQPYI------RFCSCQLNGAALIQQKTDEAPDFKEFVKRLAMDPR 1387

  Fly  1672 CRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKT 1736
            |:.:.|...:...:||:|:|||:.:|:.:.|    |||..:...::.|:|.::.:..:||:.|:.
Mouse  1388 CKGMPLSSFILKPMQRVTRYPLIIKNILENT----PENHPDHSHLKHALEKAEELCSQVNEGVRE 1448

  Fly  1737 AEDAHKLQNIQRKLDRSSYDKE-EFKKLD--LTQHHLIHDGNLTIKKNPSVQLHGLLFENMIVL- 1797
            .|::.:|:.||..:......:: .|..:.  |.....:|.|.| .|...:.:|:|.||.:.::| 
Mouse  1449 KENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKL-YKAKSNKELYGFLFNDFLLLT 1512

  Fly  1798 -LTKQ-----DDKYY-------LKNLHTPLSIT------------NKPVSPIMSIDADTLIRQEA 1837
             :||.     .||.:       .|...||:.:.            ::|:..|..||....:|.|:
Mouse  1513 QITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAES 1577

  Fly  1838 ADKNSFFLIKMKTSQMLELRAPSSSECKTW 1867
            .::.:.::.|:|.:..|.:........|.:
Mouse  1578 INERTAWVQKIKAASELYIETEKKKREKAY 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570 11/77 (14%)
RGS_GEF_like 934..1055 CDD:188710 21/120 (18%)
C1_1 1151..1202 CDD:278556 5/50 (10%)
RhoGEF 1539..1731 CDD:238091 47/196 (24%)
PH_RhoGEF 1770..1875 CDD:275411 26/124 (21%)
DUF2413 2242..>2378 CDD:287302
Itsn1XP_006522994.1 EH 39..132 CDD:197477 1/1 (100%)
PLN02983 <155..226 CDD:215533 19/109 (17%)
EH 238..333 CDD:197477 20/103 (19%)
PTZ00121 <355..739 CDD:173412 80/435 (18%)
SH3 766..825 CDD:388381 15/70 (21%)
INTAP 825..939 CDD:374674 30/120 (25%)
SH3_Intersectin1_2 939..990 CDD:212922 17/135 (13%)
SH3_Intersectin1_3 1028..1079 CDD:212924 13/161 (8%)
SH3_Intersectin1_4 1096..1160 CDD:212926 13/65 (20%)
SH3_Intersectin1_5 1180..1233 CDD:212928 7/70 (10%)
RhoGEF 1260..1443 CDD:238091 47/196 (24%)
PH_13 1462..1615 CDD:374702 28/147 (19%)
C2_Intersectin 1604..1738 CDD:176021 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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