DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF2 and Fgd1

DIOPT Version :9

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:NP_032027.2 Gene:Fgd1 / 14163 MGIID:104566 Length:960 Species:Mus musculus


Alignment Length:940 Identity:179/940 - (19%)
Similarity:303/940 - (32%) Gaps:318/940 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1425 GSESPSTSMEH---FAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSS 1486
            ||:.|......   ..|||...|.:||                      .:||   |:...:..|
Mouse   253 GSQLPEGEASRCLFLLAPGPRDGEKVP----------------------NRDS---GIDSISSPS 292

  Fly  1487 AASNSSFWNAGHP--------------LPVA------------RWTLESEDEDDVNEADWSSMV- 1524
            .:..:.|.:...|              :|||            ...||.|:|::..|.:....| 
Mouse   293 NSEETCFVSDDGPPIHSLCPGPPALASMPVALADPHRPGSQEVDSDLEEEEEEEEEEKEREIPVP 357

  Fly  1525 --AAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPAL 1587
              ..:....|| .::|...|.||:.|||:.:|..|.|||::|...|.|.......     ||..:
Mouse   358 PMERQESVELT-VQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSS-----FPADV 416

  Fly  1588 LSLREIHGAF----------EQSL---KQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFC 1639
                 :||.|          :|.|   .::|:|.......|||:|      |......:...::.
Mouse   417 -----VHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDIL------QKLAPFLKMYGEYV 470

  Fly  1640 ARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFEN-LYKVTV 1703
            .....|:|.:.....:....:.::.:.:..:||..|.|:..:...:||:.:|.||.:: |.|   
Mouse   471 KNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLK--- 532

  Fly  1704 RLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKL----DRSSYDKEEFKKLD 1764
              ||..:.:::..|:::|.........|.|::..|..|||..:...|    |..|..||..|   
Mouse   533 --LPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIK--- 592

  Fly  1765 LTQHHLIHDGNLTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDA 1829
              :.|::   .|:.|...:...:.:||.:.::....:            |.:..:..|....||.
Mouse   593 --EGHIL---KLSAKNGTTQDRYLILFNDRLLYCVPR------------LRLLGQKFSVRARIDV 640

  Fly  1830 DTLIRQEAADKN--SFFLIKMKTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDT 1892
            |.:..:|:::.|  ..||:..| .:.|||:|.:..|.|.|.:..:.                   
Mouse   641 DGMELKESSNLNMPRTFLVSGK-QRSLELQARTEEEKKDWVQAINS------------------- 685

  Fly  1893 SISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTG 1957
                   ..:.|..|.|:.:|...|.:.     ...|.|.:|.:.:....|.|.           
Mouse   686 -------TLLKHEQTLETFKLLNSTNRD-----DEDTPPNSPNVDLGKRAPTPI----------- 727

  Fly  1958 VQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLR--HS 2020
                                       .:.||  ||.:|.. ||.          |.:|.|  |.
Mouse   728 ---------------------------REKEV--TMCMRCQ-EPF----------NSITKRRHHC 752

  Fly  2021 QSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVDPTAIQVSISPA 2085
            ::...                :|.|......|.::..||.:|...          |...|::..|
Mouse   753 KACGH----------------VVCGKCSEFRARLIYDNNRSNRVC----------TDCYVALHGA 791

  Fly  2086 HTAEPVLTPGEKLRRLDASIRNDLLEKQ-------KIICDIFRLPVEHYDQIVDIAMMPEAPK-- 2141
            ..:.|..:.....|      |..:||||       .:||...     ||        |.:..|  
Mouse   792 PGSSPACSQHTPQR------RRSILEKQASVAAENSVICSFL-----HY--------MEKGGKGW 837

  Fly  2142 --------DSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHCHEKEKLRKKVAPSS 2198
                    ::..:.|               |::..| |:|.|                ::..|..
Mouse   838 HKAWFVVPENEPLVL---------------YIYGAP-QDVKA----------------QRSLPLI 870

  Fly  2199 SFSSSPPPL-PPPNRQHAQAQAQIPPSRL----MPKLQTLDLDEVAI---HEDDDGYCEIDELRL 2255
            .|...||.. ..|:|:|.   .:|..|.|    .|:.:.|....:|:   ....|.:|....|  
Mouse   871 GFEVGPPEAGERPDRRHV---FKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTL-- 930

  Fly  2256 PAIPSKPHERPTTPLAPFNT---EPKTSQS 2282
                |:..|...||:|....   .|:.||:
Mouse   931 ----SEDKEMEETPVAASGATAEPPEASQT 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ 260..334 CDD:214570
RGS_GEF_like 934..1055 CDD:188710
C1_1 1151..1202 CDD:278556
RhoGEF 1539..1731 CDD:238091 45/205 (22%)
PH_RhoGEF 1770..1875 CDD:275411 21/106 (20%)
DUF2413 2242..>2378 CDD:287302 11/44 (25%)
Fgd1NP_032027.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..210
SH3-binding. /evidence=ECO:0000255 171..187
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..355 23/126 (18%)
RhoGEF 375..558 CDD:238091 45/203 (22%)
PH1_FGD1 590..697 CDD:275392 26/153 (17%)
PH 590..687 CDD:278594 23/143 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..725 4/28 (14%)
FYVE_FGD1_2_4 724..788 CDD:277280 21/140 (15%)
PH2_FGD1-4 814..919 CDD:270056 25/152 (16%)
PH 822..920 CDD:278594 25/145 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..960 11/41 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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